p73 and p63 Are Homotetramers Capable of Weak Heterotypic Interactions with Each Other but Not with p53

Mutations in the p53 tumor suppressor gene are the most frequent genetic alterations found in human cancers. Recent identification of two human homologues of p53 has raised the prospect of functional interactions between family members via a conserved oligomerization domain. Here we report in vitro...

Ausführliche Beschreibung