Functional and Physical Interaction between WRN Helicase and Human Replication Protein A

The human premature aging disorder Werner syndrome (WS) is associated with a large number of symptoms displayed in normal aging. The WRN gene product, a DNA helicase, has been previously shown to unwind short DNA duplexes (â¤53 base pairs) in a reaction stimulated by single-stranded DNA-binding pro...

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Veröffentlicht in:	The Journal of biological chemistry 1999-06, Vol.274 (26), p.18341-18350
Hauptverfasser:	Brosh, Jr, R M, Orren, D K, Nehlin, J O, Ravn, P H, Kenny, M K, Machwe, A, Bohr, V A
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteriophage T4 - metabolism DNA Helicases - metabolism DNA, Single-Stranded - metabolism DNA-Binding Proteins - metabolism Escherichia coli Exodeoxyribonucleases Fluorescent Dyes - metabolism Humans Kinetics Molecular Weight Organic Chemicals Phage T4 Protein Binding Recombinant Proteins - metabolism RecQ Helicases Replication Protein A Structure-Activity Relationship Viral Proteins - metabolism Werner Syndrome Helicase
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