Tumor growth inhibition and regression induced by photothermal vascular targeting and angiogenesis inhibitor retinoic acid
The effect of photothermal vascular targeting, alone and in combination with antiangiogenic therapy, was evaluated using tumors produced in mice by transplantation of KB cells. Tumor growth inhibition and regression followed vascular damage produced by pulsed dye laser (PDL) radiation. Administratio...
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| Veröffentlicht in: | Cancer letters 1999-03, Vol.137 (1), p.35-44 |
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| container_title | Cancer letters |
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| creator | McMillan, Kathleen Perepelitsyn, Ilya Wang, Zhi Shapshay, Stanley M. |
| description | The effect of photothermal vascular targeting, alone and in combination with antiangiogenic therapy, was evaluated using tumors produced in mice by transplantation of KB cells. Tumor growth inhibition and regression followed vascular damage produced by pulsed dye laser (PDL) radiation. Administration of the antiangiogenic agent all-
trans-retinoic acid (RA) was associated with smaller average tumor volumes in the presence and absence of PDL irradiation, but this effect was not statistically significant. The ability of PDL photothermal vascular targeting to cause regression of tumors without harming normal tissue may be a consequence of preferential damage to supplying vessels at the tumor periphery. |
| doi_str_mv | 10.1016/S0304-3835(98)00339-5 |
| format | Article |
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trans-retinoic acid (RA) was associated with smaller average tumor volumes in the presence and absence of PDL irradiation, but this effect was not statistically significant. The ability of PDL photothermal vascular targeting to cause regression of tumors without harming normal tissue may be a consequence of preferential damage to supplying vessels at the tumor periphery.</description><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - blood supply</subject><subject>Carcinoma, Squamous Cell - drug therapy</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Combined Modality Therapy</subject><subject>Combined treatments (chemotherapy of immunotherapy associated with an other treatment)</subject><subject>Humans</subject><subject>Laser Coagulation - methods</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Microvasculature, Pulsed dye laser</subject><subject>Neovascularization, Pathologic - drug therapy</subject><subject>Neovascularization, Pathologic - surgery</subject><subject>Pharmacology. Drug treatments</subject><subject>Squamous cell cancer</subject><subject>Tretinoin - therapeutic use</subject><subject>Tumor Cells, Cultured</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtv1TAQRi0EoreFnwDyAqGyCNhx_FpVqOIlVWJBWVuOM8k1SuyL7RSVX4_vg8eO1WhG55sZHYSeUfKaEirefCGMdA1TjF9q9YoQxnTDH6ANVbJtpFbkIdr8Qc7Qec7fCCG8k_wxOqOESSF1u0E_b9clJjyl-KNssQ9b3_viY8A2DDjBlCDnfevDsDoYcH-Pd9tYYtlCWuyM72x262wTLjZNUHyYDkkbJh8nCJB9_r21nkl7InqHrfPDE_RotHOGp6d6gb6-f3d7_bG5-fzh0_Xbm8YxTUrTcQWCWqFGzXvSqZYOHQxW9ZxQCUwowQShoMeWgxolUAf92HZC1EnLnWMX6OVx7y7F7yvkYhafHcyzDRDXbIRWrNUdqSA_gi7FnBOMZpf8YtO9ocTspZuDdLM3arQyB-mG19zz04G1X2D4J3W0XIEXJ6DasvOYbHA-_-Wk1JJ1Fbs6YlBt3HlIJjsPoWr3CVwxQ_T_-eQXJaag3A</recordid><startdate>19990322</startdate><enddate>19990322</enddate><creator>McMillan, Kathleen</creator><creator>Perepelitsyn, Ilya</creator><creator>Wang, Zhi</creator><creator>Shapshay, Stanley M.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990322</creationdate><title>Tumor growth inhibition and regression induced by photothermal vascular targeting and angiogenesis inhibitor retinoic acid</title><author>McMillan, Kathleen ; Perepelitsyn, Ilya ; Wang, Zhi ; Shapshay, Stanley M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-458e61a68f95b04821d4eda8b5017e36863601e9f25e8f7e1cebf24669f225cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - blood supply</topic><topic>Carcinoma, Squamous Cell - drug therapy</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Combined Modality Therapy</topic><topic>Combined treatments (chemotherapy of immunotherapy associated with an other treatment)</topic><topic>Humans</topic><topic>Laser Coagulation - methods</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Microvasculature, Pulsed dye laser</topic><topic>Neovascularization, Pathologic - drug therapy</topic><topic>Neovascularization, Pathologic - surgery</topic><topic>Pharmacology. 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Tumor growth inhibition and regression followed vascular damage produced by pulsed dye laser (PDL) radiation. Administration of the antiangiogenic agent all-
trans-retinoic acid (RA) was associated with smaller average tumor volumes in the presence and absence of PDL irradiation, but this effect was not statistically significant. The ability of PDL photothermal vascular targeting to cause regression of tumors without harming normal tissue may be a consequence of preferential damage to supplying vessels at the tumor periphery.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>10376792</pmid><doi>10.1016/S0304-3835(98)00339-5</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 1999-03, Vol.137 (1), p.35-44 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Antineoplastic agents Antineoplastic Agents - therapeutic use Biological and medical sciences Carcinoma, Squamous Cell - blood supply Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - surgery Combined Modality Therapy Combined treatments (chemotherapy of immunotherapy associated with an other treatment) Humans Laser Coagulation - methods Medical sciences Mice Mice, Nude Microvasculature, Pulsed dye laser Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - surgery Pharmacology. Drug treatments Squamous cell cancer Tretinoin - therapeutic use Tumor Cells, Cultured |
| title | Tumor growth inhibition and regression induced by photothermal vascular targeting and angiogenesis inhibitor retinoic acid |
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