Interactions of PACAP and Ceramides in the Control of Granule Cell Apoptosis During Cerebellar Development
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide that belongs to the secretin/glucagon/vasoactive intestinal polypeptide superfamily. The PACAPergic system is actively expressed in the developing cerebellum of mammals. In particular, PACAP receptors are expressed by granu...
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| Veröffentlicht in: | Journal of molecular neuroscience 2008-11, Vol.36 (1-3), p.8-15 |
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| container_title | Journal of molecular neuroscience |
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| creator | Falluel-Morel, A. Aubert, N. Vaudry, D. Desfeux, A. Allais, A. Burel, D. Basille, M. Vaudry, H. Laudenbach, V. Gonzalez, B. J. |
| description | Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide that belongs to the secretin/glucagon/vasoactive intestinal polypeptide superfamily. The PACAPergic system is actively expressed in the developing cerebellum of mammals. In particular, PACAP receptors are expressed by granule cell precursors suggesting a role of the peptide in neurogenesis of this cell type. Consistent with this hypothesis, several studies reported antiapoptotic effects of PACAP in the developing cerebellum. On the other hand, the sphingomyelin metabolites ceramides are recognized as important signaling molecules that play pivotal roles during neuronal development. Ceramides, which production can be induced by death factors such as FasL or TNFalpha, are involved in the control of cell survival during brain development through activation of caspase-dependent mechanisms. The present review focuses on the interactions between PACAP and ceramides in the control of granule cell survival and on the transduction mechanisms associated with the anti- and proapoptotic effects of PACAP and ceramides, respectively. |
| doi_str_mv | 10.1007/s12031-008-9111-5 |
| format | Article |
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Ceramides, which production can be induced by death factors such as FasL or TNFalpha, are involved in the control of cell survival during brain development through activation of caspase-dependent mechanisms. The present review focuses on the interactions between PACAP and ceramides in the control of granule cell survival and on the transduction mechanisms associated with the anti- and proapoptotic effects of PACAP and ceramides, respectively.</description><identifier>ISSN: 0895-8696</identifier><identifier>EISSN: 1559-1166</identifier><identifier>DOI: 10.1007/s12031-008-9111-5</identifier><identifier>PMID: 18574733</identifier><language>eng</language><publisher>New York: Humana Press Inc</publisher><subject>Animals ; Apoptosis - physiology ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Ceramides - chemistry ; Ceramides - metabolism ; Cerebellum - cytology ; Cerebellum - growth & development ; Molecular Structure ; Neurochemistry ; Neurology ; Neurons - cytology ; Neurons - physiology ; Neurosciences ; Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism ; Polypeptides ; Proteomics ; Second Messenger Systems - physiology</subject><ispartof>Journal of molecular neuroscience, 2008-11, Vol.36 (1-3), p.8-15</ispartof><rights>Humana Press 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-ccd4ee0ac1233aa6a86876bfce67d35df534ee27eba64bce018961ae3d4816243</citedby><cites>FETCH-LOGICAL-c466t-ccd4ee0ac1233aa6a86876bfce67d35df534ee27eba64bce018961ae3d4816243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12031-008-9111-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12031-008-9111-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18574733$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Falluel-Morel, A.</creatorcontrib><creatorcontrib>Aubert, N.</creatorcontrib><creatorcontrib>Vaudry, D.</creatorcontrib><creatorcontrib>Desfeux, A.</creatorcontrib><creatorcontrib>Allais, A.</creatorcontrib><creatorcontrib>Burel, D.</creatorcontrib><creatorcontrib>Basille, M.</creatorcontrib><creatorcontrib>Vaudry, H.</creatorcontrib><creatorcontrib>Laudenbach, V.</creatorcontrib><creatorcontrib>Gonzalez, B. J.</creatorcontrib><title>Interactions of PACAP and Ceramides in the Control of Granule Cell Apoptosis During Cerebellar Development</title><title>Journal of molecular neuroscience</title><addtitle>J Mol Neurosci</addtitle><addtitle>J Mol Neurosci</addtitle><description>Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide that belongs to the secretin/glucagon/vasoactive intestinal polypeptide superfamily. The PACAPergic system is actively expressed in the developing cerebellum of mammals. In particular, PACAP receptors are expressed by granule cell precursors suggesting a role of the peptide in neurogenesis of this cell type. Consistent with this hypothesis, several studies reported antiapoptotic effects of PACAP in the developing cerebellum. On the other hand, the sphingomyelin metabolites ceramides are recognized as important signaling molecules that play pivotal roles during neuronal development. Ceramides, which production can be induced by death factors such as FasL or TNFalpha, are involved in the control of cell survival during brain development through activation of caspase-dependent mechanisms. The present review focuses on the interactions between PACAP and ceramides in the control of granule cell survival and on the transduction mechanisms associated with the anti- and proapoptotic effects of PACAP and ceramides, respectively.</description><subject>Animals</subject><subject>Apoptosis - physiology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Ceramides - chemistry</subject><subject>Ceramides - metabolism</subject><subject>Cerebellum - cytology</subject><subject>Cerebellum - growth & development</subject><subject>Molecular Structure</subject><subject>Neurochemistry</subject><subject>Neurology</subject><subject>Neurons - cytology</subject><subject>Neurons - physiology</subject><subject>Neurosciences</subject><subject>Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism</subject><subject>Polypeptides</subject><subject>Proteomics</subject><subject>Second Messenger Systems - physiology</subject><issn>0895-8696</issn><issn>1559-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkUFr3DAQhUVp6G7T_oBegughNycay5Ll4-I0aSCQPaRnIcvj1ostOZJd6L-PzC4EAqEnwcz33ozmEfIN2BUwVl5HyBmHjDGVVQCQiQ9kC0JUGYCUH8mWqUpkSlZyQz7HeGAshwLUJ7IBJcqi5HxLDvduxmDs3HsXqe_oflfv9tS4ltapPvYtRto7Ov9BWns3Bz-s1F0wbhlSCYeB7iY_zT72kd4soXe_VyU2qWMCvcG_OPhpRDd_IWedGSJ-Pb3n5Nftj6f6Z_bweHdf7x4yW0g5Z9a2BSIzFnLOjZFGSVXKprMoy5aLthM89fMSGyOLxiIDVUkwyNtCgcwLfk4uj75T8M8LxlmPfbTrOg79ErWsFAfJ4b9gDjxdU_AEfn8DHvwSXPqEVmmmUFWuEgRHyAYfY8BOT6EfTfingek1Ln2MS6e49BqXFklzcTJemhHbV8UpnwTkRyBO62UxvE5-3_UFhvyfjQ</recordid><startdate>20081101</startdate><enddate>20081101</enddate><creator>Falluel-Morel, A.</creator><creator>Aubert, N.</creator><creator>Vaudry, D.</creator><creator>Desfeux, A.</creator><creator>Allais, A.</creator><creator>Burel, D.</creator><creator>Basille, M.</creator><creator>Vaudry, H.</creator><creator>Laudenbach, V.</creator><creator>Gonzalez, B. J.</creator><general>Humana Press Inc</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20081101</creationdate><title>Interactions of PACAP and Ceramides in the Control of Granule Cell Apoptosis During Cerebellar Development</title><author>Falluel-Morel, A. ; Aubert, N. ; Vaudry, D. ; Desfeux, A. ; Allais, A. ; Burel, D. ; Basille, M. ; Vaudry, H. ; Laudenbach, V. ; Gonzalez, B. 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Consistent with this hypothesis, several studies reported antiapoptotic effects of PACAP in the developing cerebellum. On the other hand, the sphingomyelin metabolites ceramides are recognized as important signaling molecules that play pivotal roles during neuronal development. Ceramides, which production can be induced by death factors such as FasL or TNFalpha, are involved in the control of cell survival during brain development through activation of caspase-dependent mechanisms. The present review focuses on the interactions between PACAP and ceramides in the control of granule cell survival and on the transduction mechanisms associated with the anti- and proapoptotic effects of PACAP and ceramides, respectively.</abstract><cop>New York</cop><pub>Humana Press Inc</pub><pmid>18574733</pmid><doi>10.1007/s12031-008-9111-5</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Apoptosis - physiology Biomedical and Life Sciences Biomedicine Cell Biology Ceramides - chemistry Ceramides - metabolism Cerebellum - cytology Cerebellum - growth & development Molecular Structure Neurochemistry Neurology Neurons - cytology Neurons - physiology Neurosciences Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism Polypeptides Proteomics Second Messenger Systems - physiology |
| title | Interactions of PACAP and Ceramides in the Control of Granule Cell Apoptosis During Cerebellar Development |
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