Murine metastatic tumour models for cancer gene therapy research
The appropriate use of animal tumour models has a pivotal role in the evaluation of any new anti-cancer therapy. Indeed, animal models of human diseases have been emphasised in the early development and evaluation of gene therapy. Given that most cancer treatment failures and cancer-related mortalit...
Gespeichert in:
Veröffentlicht in: | Annals of the Academy of Medicine, Singapore Singapore, 1999-01, Vol.28 (1), p.112-119 |
---|---|
1. Verfasser: | |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 119 |
---|---|
container_issue | 1 |
container_start_page | 112 |
container_title | Annals of the Academy of Medicine, Singapore |
container_volume | 28 |
creator | Kong, H L |
description | The appropriate use of animal tumour models has a pivotal role in the evaluation of any new anti-cancer therapy. Indeed, animal models of human diseases have been emphasised in the early development and evaluation of gene therapy. Given that most cancer treatment failures and cancer-related mortality are the direct results of metastatic cancers, the increasing use of clinically-relevant metastatic tumour models in the study of cancer therapeutics is both logical and necessary. Murine metastatic tumour models may be established either "experimentally" or "spontaneously". The yield and reproducibility of spontaneous metastasis models can be enhanced through manoeuvres such as using highly-metastatic sublines for primary tumour implantation and orthotropic transplantation. The use of immunodeficient rodents, although popular, suffers from the absence of T-cell responses in the host which may impact on therapeutic efficacy. While many gene therapy strategies today are capable of regressing primary tumours in experimental animals, only a limited number of approaches (viz. genetic immunotherapy and gene-mediated anti-angiogenesis) are designed to address the challenges posed by metastatic tumours. In extrapolating the results of gene therapy in animal models to humans, it is important to appreciate the heterogeneity of the latter populations, and anticipate greater variability in the treatment outcome. |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_69831126</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69831126</sourcerecordid><originalsourceid>FETCH-LOGICAL-p122t-4ae731d263c1a3410cb2c9aa3dcfd8d1c8d8e80b259051a678a64b153356078e3</originalsourceid><addsrcrecordid>eNo1jztPwzAURj2AaAn8BeSJLZJfcZwNVPGSilhgjm7sGxoUJ8GPof-eSLTDp7McHem7IFsmmSqVZmJDrmP8YUzVTOgrsuFM1mrdljy85zBMSD0miAnSYGnKfs6B-tnhGGk_B2phshjoN65iOmCA5UgDRoRgDzfksocx4u2JBfl6fvrcvZb7j5e33eO-XLgQqVSAteROaGk5SMWZ7YRtAKSzvTOOW-MMGtaJqmEVB10b0KrjlZSVZrVBWZD7_-4S5t-MMbV-iBbHESacc2x1YyTna78gdycxdx5du4TBQzi258_yD8B0UYA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69831126</pqid></control><display><type>article</type><title>Murine metastatic tumour models for cancer gene therapy research</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Kong, H L</creator><creatorcontrib>Kong, H L</creatorcontrib><description>The appropriate use of animal tumour models has a pivotal role in the evaluation of any new anti-cancer therapy. Indeed, animal models of human diseases have been emphasised in the early development and evaluation of gene therapy. Given that most cancer treatment failures and cancer-related mortality are the direct results of metastatic cancers, the increasing use of clinically-relevant metastatic tumour models in the study of cancer therapeutics is both logical and necessary. Murine metastatic tumour models may be established either "experimentally" or "spontaneously". The yield and reproducibility of spontaneous metastasis models can be enhanced through manoeuvres such as using highly-metastatic sublines for primary tumour implantation and orthotropic transplantation. The use of immunodeficient rodents, although popular, suffers from the absence of T-cell responses in the host which may impact on therapeutic efficacy. While many gene therapy strategies today are capable of regressing primary tumours in experimental animals, only a limited number of approaches (viz. genetic immunotherapy and gene-mediated anti-angiogenesis) are designed to address the challenges posed by metastatic tumours. In extrapolating the results of gene therapy in animal models to humans, it is important to appreciate the heterogeneity of the latter populations, and anticipate greater variability in the treatment outcome.</description><identifier>ISSN: 0304-4602</identifier><identifier>PMID: 10374037</identifier><language>eng</language><publisher>Singapore</publisher><subject>Animals ; Disease Models, Animal ; Genetic Therapy ; Mice ; Neoplasm Metastasis ; Neoplasms, Experimental - pathology ; Neoplasms, Experimental - therapy</subject><ispartof>Annals of the Academy of Medicine, Singapore, 1999-01, Vol.28 (1), p.112-119</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10374037$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kong, H L</creatorcontrib><title>Murine metastatic tumour models for cancer gene therapy research</title><title>Annals of the Academy of Medicine, Singapore</title><addtitle>Ann Acad Med Singapore</addtitle><description>The appropriate use of animal tumour models has a pivotal role in the evaluation of any new anti-cancer therapy. Indeed, animal models of human diseases have been emphasised in the early development and evaluation of gene therapy. Given that most cancer treatment failures and cancer-related mortality are the direct results of metastatic cancers, the increasing use of clinically-relevant metastatic tumour models in the study of cancer therapeutics is both logical and necessary. Murine metastatic tumour models may be established either "experimentally" or "spontaneously". The yield and reproducibility of spontaneous metastasis models can be enhanced through manoeuvres such as using highly-metastatic sublines for primary tumour implantation and orthotropic transplantation. The use of immunodeficient rodents, although popular, suffers from the absence of T-cell responses in the host which may impact on therapeutic efficacy. While many gene therapy strategies today are capable of regressing primary tumours in experimental animals, only a limited number of approaches (viz. genetic immunotherapy and gene-mediated anti-angiogenesis) are designed to address the challenges posed by metastatic tumours. In extrapolating the results of gene therapy in animal models to humans, it is important to appreciate the heterogeneity of the latter populations, and anticipate greater variability in the treatment outcome.</description><subject>Animals</subject><subject>Disease Models, Animal</subject><subject>Genetic Therapy</subject><subject>Mice</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasms, Experimental - pathology</subject><subject>Neoplasms, Experimental - therapy</subject><issn>0304-4602</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1jztPwzAURj2AaAn8BeSJLZJfcZwNVPGSilhgjm7sGxoUJ8GPof-eSLTDp7McHem7IFsmmSqVZmJDrmP8YUzVTOgrsuFM1mrdljy85zBMSD0miAnSYGnKfs6B-tnhGGk_B2phshjoN65iOmCA5UgDRoRgDzfksocx4u2JBfl6fvrcvZb7j5e33eO-XLgQqVSAteROaGk5SMWZ7YRtAKSzvTOOW-MMGtaJqmEVB10b0KrjlZSVZrVBWZD7_-4S5t-MMbV-iBbHESacc2x1YyTna78gdycxdx5du4TBQzi258_yD8B0UYA</recordid><startdate>199901</startdate><enddate>199901</enddate><creator>Kong, H L</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199901</creationdate><title>Murine metastatic tumour models for cancer gene therapy research</title><author>Kong, H L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p122t-4ae731d263c1a3410cb2c9aa3dcfd8d1c8d8e80b259051a678a64b153356078e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Disease Models, Animal</topic><topic>Genetic Therapy</topic><topic>Mice</topic><topic>Neoplasm Metastasis</topic><topic>Neoplasms, Experimental - pathology</topic><topic>Neoplasms, Experimental - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kong, H L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of the Academy of Medicine, Singapore</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kong, H L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Murine metastatic tumour models for cancer gene therapy research</atitle><jtitle>Annals of the Academy of Medicine, Singapore</jtitle><addtitle>Ann Acad Med Singapore</addtitle><date>1999-01</date><risdate>1999</risdate><volume>28</volume><issue>1</issue><spage>112</spage><epage>119</epage><pages>112-119</pages><issn>0304-4602</issn><abstract>The appropriate use of animal tumour models has a pivotal role in the evaluation of any new anti-cancer therapy. Indeed, animal models of human diseases have been emphasised in the early development and evaluation of gene therapy. Given that most cancer treatment failures and cancer-related mortality are the direct results of metastatic cancers, the increasing use of clinically-relevant metastatic tumour models in the study of cancer therapeutics is both logical and necessary. Murine metastatic tumour models may be established either "experimentally" or "spontaneously". The yield and reproducibility of spontaneous metastasis models can be enhanced through manoeuvres such as using highly-metastatic sublines for primary tumour implantation and orthotropic transplantation. The use of immunodeficient rodents, although popular, suffers from the absence of T-cell responses in the host which may impact on therapeutic efficacy. While many gene therapy strategies today are capable of regressing primary tumours in experimental animals, only a limited number of approaches (viz. genetic immunotherapy and gene-mediated anti-angiogenesis) are designed to address the challenges posed by metastatic tumours. In extrapolating the results of gene therapy in animal models to humans, it is important to appreciate the heterogeneity of the latter populations, and anticipate greater variability in the treatment outcome.</abstract><cop>Singapore</cop><pmid>10374037</pmid><tpages>8</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0304-4602 |
ispartof | Annals of the Academy of Medicine, Singapore, 1999-01, Vol.28 (1), p.112-119 |
issn | 0304-4602 |
language | eng |
recordid | cdi_proquest_miscellaneous_69831126 |
source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
subjects | Animals Disease Models, Animal Genetic Therapy Mice Neoplasm Metastasis Neoplasms, Experimental - pathology Neoplasms, Experimental - therapy |
title | Murine metastatic tumour models for cancer gene therapy research |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T22%3A30%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Murine%20metastatic%20tumour%20models%20for%20cancer%20gene%20therapy%20research&rft.jtitle=Annals%20of%20the%20Academy%20of%20Medicine,%20Singapore&rft.au=Kong,%20H%20L&rft.date=1999-01&rft.volume=28&rft.issue=1&rft.spage=112&rft.epage=119&rft.pages=112-119&rft.issn=0304-4602&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E69831126%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69831126&rft_id=info:pmid/10374037&rfr_iscdi=true |