Fatty acid synthase expression is increased in neoplastic lesions of the oral tongue
Background Fatty acid synthase (FASE) is required for fatty acid synthesis. Elevated levels of FASE have been observed in a variety of malignancies. Methods We examined the expression of FASE in 56 primary squamous cell carcinomas (SCC) of the tongue using immunohistochemistry (IHC) with a monoclona...
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| Veröffentlicht in: | Head & neck 1999-07, Vol.21 (4), p.325-329 |
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| creator | Krontiras, Helen Roye, G. Dean Beenken, Samuel E. Myers, Russell B. Mayo, Matthew S. Peters, Glenn E. Grizzle, William E. |
| description | Background
Fatty acid synthase (FASE) is required for fatty acid synthesis. Elevated levels of FASE have been observed in a variety of malignancies.
Methods
We examined the expression of FASE in 56 primary squamous cell carcinomas (SCC) of the tongue using immunohistochemistry (IHC) with a monoclonal antibody to FASE.
Results
Immunoreactivity was low in histologically normal epithelium (0.42 ± .07, n = 43), moderate in mildly dysplastic epithelium (1.41 ± 11, n = 40), and strong in SCC of the tongue (1.64 ± 10, n = 50). Both mild dysplasia and SCC stained more strongly than histologically normal epithelium (p |
| doi_str_mv | 10.1002/(SICI)1097-0347(199907)21:4<325::AID-HED6>3.0.CO;2-P |
| format | Article |
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Fatty acid synthase (FASE) is required for fatty acid synthesis. Elevated levels of FASE have been observed in a variety of malignancies.
Methods
We examined the expression of FASE in 56 primary squamous cell carcinomas (SCC) of the tongue using immunohistochemistry (IHC) with a monoclonal antibody to FASE.
Results
Immunoreactivity was low in histologically normal epithelium (0.42 ± .07, n = 43), moderate in mildly dysplastic epithelium (1.41 ± 11, n = 40), and strong in SCC of the tongue (1.64 ± 10, n = 50). Both mild dysplasia and SCC stained more strongly than histologically normal epithelium (p<0.00001). Well‐differentiated tumors showed increased immunoreactivity when compared to less well‐differentiated tumors (p=0.044). Decreased overall survival was observed among patients with tumors with low immunoreactivity (p=0.04).
Conclusions
Increased expression of FASE in dysplasia and squamous carcinomas of the oral tongue may be an indicator of both differentiation and early neoplastic change. FASE expression may be useful diagnostically, prognostically, and as a potential target for therapy. © 1999 John Wiley & Sons, Inc. Head Neck 21: 325–329, 1999.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/(SICI)1097-0347(199907)21:4<325::AID-HED6>3.0.CO;2-P</identifier><identifier>PMID: 10376752</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antibodies, Monoclonal ; Biological and medical sciences ; Carcinoma, Squamous Cell - enzymology ; Carcinoma, Squamous Cell - pathology ; Epithelium - enzymology ; fatty acid synthase ; Fatty Acid Synthases - metabolism ; Female ; Humans ; Immunohistochemistry ; Male ; Medical sciences ; Middle Aged ; Neoplasm Staging ; oral tongue neoplasm ; Otorhinolaryngology. Stomatology ; Tongue Neoplasms - enzymology ; Tongue Neoplasms - pathology ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Head & neck, 1999-07, Vol.21 (4), p.325-329</ispartof><rights>Copyright © 1999 John Wiley & Sons, Inc.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4286-e9cdbdab3bcfe776cd3e2de578dd61bf7d4be74d7bfa748a9690fd688dc0b5be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291097-0347%28199907%2921%3A4%3C325%3A%3AAID-HED6%3E3.0.CO%3B2-P$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291097-0347%28199907%2921%3A4%3C325%3A%3AAID-HED6%3E3.0.CO%3B2-P$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1796891$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10376752$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krontiras, Helen</creatorcontrib><creatorcontrib>Roye, G. Dean</creatorcontrib><creatorcontrib>Beenken, Samuel E.</creatorcontrib><creatorcontrib>Myers, Russell B.</creatorcontrib><creatorcontrib>Mayo, Matthew S.</creatorcontrib><creatorcontrib>Peters, Glenn E.</creatorcontrib><creatorcontrib>Grizzle, William E.</creatorcontrib><title>Fatty acid synthase expression is increased in neoplastic lesions of the oral tongue</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
Fatty acid synthase (FASE) is required for fatty acid synthesis. Elevated levels of FASE have been observed in a variety of malignancies.
Methods
We examined the expression of FASE in 56 primary squamous cell carcinomas (SCC) of the tongue using immunohistochemistry (IHC) with a monoclonal antibody to FASE.
Results
Immunoreactivity was low in histologically normal epithelium (0.42 ± .07, n = 43), moderate in mildly dysplastic epithelium (1.41 ± 11, n = 40), and strong in SCC of the tongue (1.64 ± 10, n = 50). Both mild dysplasia and SCC stained more strongly than histologically normal epithelium (p<0.00001). Well‐differentiated tumors showed increased immunoreactivity when compared to less well‐differentiated tumors (p=0.044). Decreased overall survival was observed among patients with tumors with low immunoreactivity (p=0.04).
Conclusions
Increased expression of FASE in dysplasia and squamous carcinomas of the oral tongue may be an indicator of both differentiation and early neoplastic change. FASE expression may be useful diagnostically, prognostically, and as a potential target for therapy. © 1999 John Wiley & Sons, Inc. Head Neck 21: 325–329, 1999.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antibodies, Monoclonal</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - enzymology</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Epithelium - enzymology</subject><subject>fatty acid synthase</subject><subject>Fatty Acid Synthases - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>oral tongue neoplasm</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Tongue Neoplasms - enzymology</subject><subject>Tongue Neoplasms - pathology</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1v0zAUhiMEYmPwF5AvENouUvwVOykT0pSua6WJTqKIyyPHPmGGNClxqq3_fgmpNiSQuPKx9fo5r54oOmd0wijlH06_LPPlGaOZjqmQ-pRlWUb1GWdTeS54Mp1eLGfx4nKmPokJneSrjzy-eRYdP354PsxSxIJqeRS9CuEHpVQoyV9GR4wKrXTCj6P13HTdnhjrHQn7urs1AQneb1sMwTc18YH42rbYP7t-IjU228qEzltS4ZAIpClJd4ukaU1Fuqb-vsPX0YvSVAHfHM6T6Ov8cp0v4uvV1TK_uI6t5KmKMbOucKYQhS1Ra2WdQO4w0alzihWldrJALZ0uSqNlajKV0dKpNHWWFkmB4iR6P3K3bfNrh6GDjQ8Wq8r0NXcBVJbyQVofXI9B2zYhtFjCtvUb0-6BURhsAwy2YZAHgzwYbQNnIKG3DdDbhsE2CKCQr4DDTY99e9i_Kzbo_oCOevvAu0PABGuqsjW19eEppzOVZuyp3p2vcP9Xt_9U-0ez3_ceG49YHzq8f8Sa9icoLXQC3z5fwWKW6hmjc8jFA0nvt40</recordid><startdate>199907</startdate><enddate>199907</enddate><creator>Krontiras, Helen</creator><creator>Roye, G. Dean</creator><creator>Beenken, Samuel E.</creator><creator>Myers, Russell B.</creator><creator>Mayo, Matthew S.</creator><creator>Peters, Glenn E.</creator><creator>Grizzle, William E.</creator><general>John Wiley & Sons, Inc</general><general>John Wiley & Sons</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199907</creationdate><title>Fatty acid synthase expression is increased in neoplastic lesions of the oral tongue</title><author>Krontiras, Helen ; Roye, G. Dean ; Beenken, Samuel E. ; Myers, Russell B. ; Mayo, Matthew S. ; Peters, Glenn E. ; Grizzle, William E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4286-e9cdbdab3bcfe776cd3e2de578dd61bf7d4be74d7bfa748a9690fd688dc0b5be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antibodies, Monoclonal</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - enzymology</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Epithelium - enzymology</topic><topic>fatty acid synthase</topic><topic>Fatty Acid Synthases - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>oral tongue neoplasm</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Tongue Neoplasms - enzymology</topic><topic>Tongue Neoplasms - pathology</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krontiras, Helen</creatorcontrib><creatorcontrib>Roye, G. Dean</creatorcontrib><creatorcontrib>Beenken, Samuel E.</creatorcontrib><creatorcontrib>Myers, Russell B.</creatorcontrib><creatorcontrib>Mayo, Matthew S.</creatorcontrib><creatorcontrib>Peters, Glenn E.</creatorcontrib><creatorcontrib>Grizzle, William E.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krontiras, Helen</au><au>Roye, G. Dean</au><au>Beenken, Samuel E.</au><au>Myers, Russell B.</au><au>Mayo, Matthew S.</au><au>Peters, Glenn E.</au><au>Grizzle, William E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fatty acid synthase expression is increased in neoplastic lesions of the oral tongue</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>1999-07</date><risdate>1999</risdate><volume>21</volume><issue>4</issue><spage>325</spage><epage>329</epage><pages>325-329</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background
Fatty acid synthase (FASE) is required for fatty acid synthesis. Elevated levels of FASE have been observed in a variety of malignancies.
Methods
We examined the expression of FASE in 56 primary squamous cell carcinomas (SCC) of the tongue using immunohistochemistry (IHC) with a monoclonal antibody to FASE.
Results
Immunoreactivity was low in histologically normal epithelium (0.42 ± .07, n = 43), moderate in mildly dysplastic epithelium (1.41 ± 11, n = 40), and strong in SCC of the tongue (1.64 ± 10, n = 50). Both mild dysplasia and SCC stained more strongly than histologically normal epithelium (p<0.00001). Well‐differentiated tumors showed increased immunoreactivity when compared to less well‐differentiated tumors (p=0.044). Decreased overall survival was observed among patients with tumors with low immunoreactivity (p=0.04).
Conclusions
Increased expression of FASE in dysplasia and squamous carcinomas of the oral tongue may be an indicator of both differentiation and early neoplastic change. FASE expression may be useful diagnostically, prognostically, and as a potential target for therapy. © 1999 John Wiley & Sons, Inc. Head Neck 21: 325–329, 1999.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>10376752</pmid><doi>10.1002/(SICI)1097-0347(199907)21:4<325::AID-HED6>3.0.CO;2-P</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Antibodies, Monoclonal Biological and medical sciences Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - pathology Epithelium - enzymology fatty acid synthase Fatty Acid Synthases - metabolism Female Humans Immunohistochemistry Male Medical sciences Middle Aged Neoplasm Staging oral tongue neoplasm Otorhinolaryngology. Stomatology Tongue Neoplasms - enzymology Tongue Neoplasms - pathology Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Fatty acid synthase expression is increased in neoplastic lesions of the oral tongue |
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