Polyanionic Inhibitors of Phosphoglycerate Mutase: Combined Structural and Biochemical Analysis

The effects that the inhibitors inositol hexakisphosphate and benzene tri-, tetra- and hexacarboxylates have on the phosphoglycerate mutases from Saccharomyces cerevisiae and Schizosaccharomyces pombe have been determined. Their Kivalues have been calculated, and the ability of the inhibitors to pro...

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Veröffentlicht in:	Journal of molecular biology 1999-06, Vol.289 (4), p.691-699
Hauptverfasser:	Rigden, Daniel J., Walter, Rebecca A., Phillips, Simon E.V., Fothergill-Gilmore, Linda A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence benzene carboxylates Benzene Derivatives - metabolism benzene hexacarboxylate binding crystal structure Crystallography, X-Ray crystals enzyme activity enzyme inhibitors Enzyme Inhibitors - metabolism inositol hexakisphosphate isomerases Ligands Models, Molecular molecular conformation Molecular Sequence Data pdb/1bq3 pdb/1bq4 phosphoglycerate mutase Phosphoglycerate Mutase - antagonists & inhibitors Phosphoglycerate Mutase - chemistry Phosphoglycerate Mutase - metabolism Phytic Acid - metabolism polyanionic inhibitors Protein Conformation proteolysis Saccharomyces cerevisiae Saccharomyces cerevisiae - enzymology Schizosaccharomyces - enzymology Schizosaccharomyces pombe Thermolysin
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