Involvement of beta 3-adrenoceptor in altered beta-adrenergic response in senescent heart: role of nitric oxide synthase 1-derived nitric oxide

In senescent heart, beta-adrenergic response is altered in parallel with beta1- and beta2-adrenoceptor down-regulation. A negative inotropic effect of beta3-adrenoceptor could be involved. In this study, the authors tested the hypothesis that beta3-adrenoceptor plays a role in beta-adrenergic dysfun...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 2008-12, Vol.109 (6), p.1045-1053
Hauptverfasser:	Birenbaum, Aurélie, Tesse, Angela, Loyer, Xavier, Michelet, Pierre, Andriantsitohaina, Ramaroson, Heymes, Christophe, Riou, Bruno, Amour, Julien
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aging - drug effects Aging - physiology Animals In Vitro Techniques Male Myocardial Contraction - drug effects Myocardial Contraction - physiology Myocardium - enzymology NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide - antagonists & inhibitors Nitric Oxide - physiology Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - physiology Nitric Oxide Synthase Type I Rats Rats, Wistar Receptors, Adrenergic, beta-3 - physiology
Online-Zugang:	Volltext
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