Role of aminoguanidine in brain protection in surgical brain injury in rat
The study investigated the effect of aminoguanidine (AG) on surgical brain injury (SBI) in rat. AG (75, 150 and 300 mg/kg, i.p.) was administered immediately following surgical resection. Using a SBI model, we found that AG (150 mg/kg) significantly reduced cerebral edema, while AG at the doses of 7...
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| Veröffentlicht in: | Neuroscience letters 2008-12, Vol.448 (2), p.204-207 |
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| creator | Di, Fan Yan-ting, Gu Hui, Lv Tao, Tang Zai-hua, Xu Xue-ying, Shi Hong-li, Xue Yun-jie, Wang |
| description | The study investigated the effect of aminoguanidine (AG) on surgical brain injury (SBI) in rat. AG (75, 150 and 300
mg/kg, i.p.) was administered immediately following surgical resection. Using a SBI model, we found that AG (150
mg/kg) significantly reduced cerebral edema, while AG at the doses of 75 and 300
mg/kg had no effect. And AG (150
mg/kg) significantly reduced Evans Blue extravasation into brain tissue and improved the neurological outcome compared to control group. Moreover, the expression of TNF-α and nuclear factor-κB (NF-κB) mRNA and protein in brain tissue at the edge of the resection site increased at 24
h after SBI, which could be significantly attenuated by the treatment with AG via RT-PCR and Western blots methods. Our results demonstrated that SBI causes increased brain edema, BBB disruption and inflammation along the periphery of the site of surgical resection, which could be significantly improved by the treatment of AG. |
| doi_str_mv | 10.1016/j.neulet.2008.10.038 |
| format | Article |
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mg/kg, i.p.) was administered immediately following surgical resection. Using a SBI model, we found that AG (150
mg/kg) significantly reduced cerebral edema, while AG at the doses of 75 and 300
mg/kg had no effect. And AG (150
mg/kg) significantly reduced Evans Blue extravasation into brain tissue and improved the neurological outcome compared to control group. Moreover, the expression of TNF-α and nuclear factor-κB (NF-κB) mRNA and protein in brain tissue at the edge of the resection site increased at 24
h after SBI, which could be significantly attenuated by the treatment with AG via RT-PCR and Western blots methods. Our results demonstrated that SBI causes increased brain edema, BBB disruption and inflammation along the periphery of the site of surgical resection, which could be significantly improved by the treatment of AG.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2008.10.038</identifier><identifier>PMID: 18948168</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Aminoguanidine ; Animals ; BBB ; Biological and medical sciences ; Blood-Brain Barrier - drug effects ; Blood-Brain Barrier - physiopathology ; Blotting, Western ; Brain - drug effects ; Brain - metabolism ; Brain - surgery ; Brain Chemistry - drug effects ; Brain edema ; Brain Edema - drug therapy ; Brain Edema - etiology ; Brain Edema - metabolism ; Brain Injuries - diagnosis ; Brain Injuries - drug therapy ; Brain Injuries - etiology ; Brain Injuries - metabolism ; Encephalitis - drug therapy ; Evans Blue ; Extravasation of Diagnostic and Therapeutic Materials ; Fundamental and applied biological sciences. Psychology ; Guanidines - administration & dosage ; Guanidines - therapeutic use ; Male ; Neuroprotective Agents - administration & dosage ; Neuroprotective Agents - therapeutic use ; Neurosurgery ; NF-kappa B - metabolism ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - metabolism ; Surgical brain injury ; Tumor Necrosis Factor-alpha - metabolism ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 2008-12, Vol.448 (2), p.204-207</ispartof><rights>2008</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-477c7be54a52d3feaf15f1668f89c0e17629bbe12a3ea63417827723e513367e3</citedby><cites>FETCH-LOGICAL-c421t-477c7be54a52d3feaf15f1668f89c0e17629bbe12a3ea63417827723e513367e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304394008014316$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20956025$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18948168$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Di, Fan</creatorcontrib><creatorcontrib>Yan-ting, Gu</creatorcontrib><creatorcontrib>Hui, Lv</creatorcontrib><creatorcontrib>Tao, Tang</creatorcontrib><creatorcontrib>Zai-hua, Xu</creatorcontrib><creatorcontrib>Xue-ying, Shi</creatorcontrib><creatorcontrib>Hong-li, Xue</creatorcontrib><creatorcontrib>Yun-jie, Wang</creatorcontrib><title>Role of aminoguanidine in brain protection in surgical brain injury in rat</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>The study investigated the effect of aminoguanidine (AG) on surgical brain injury (SBI) in rat. AG (75, 150 and 300
mg/kg, i.p.) was administered immediately following surgical resection. Using a SBI model, we found that AG (150
mg/kg) significantly reduced cerebral edema, while AG at the doses of 75 and 300
mg/kg had no effect. And AG (150
mg/kg) significantly reduced Evans Blue extravasation into brain tissue and improved the neurological outcome compared to control group. Moreover, the expression of TNF-α and nuclear factor-κB (NF-κB) mRNA and protein in brain tissue at the edge of the resection site increased at 24
h after SBI, which could be significantly attenuated by the treatment with AG via RT-PCR and Western blots methods. Our results demonstrated that SBI causes increased brain edema, BBB disruption and inflammation along the periphery of the site of surgical resection, which could be significantly improved by the treatment of AG.</description><subject>Aminoguanidine</subject><subject>Animals</subject><subject>BBB</subject><subject>Biological and medical sciences</subject><subject>Blood-Brain Barrier - drug effects</subject><subject>Blood-Brain Barrier - physiopathology</subject><subject>Blotting, Western</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Brain - surgery</subject><subject>Brain Chemistry - drug effects</subject><subject>Brain edema</subject><subject>Brain Edema - drug therapy</subject><subject>Brain Edema - etiology</subject><subject>Brain Edema - metabolism</subject><subject>Brain Injuries - diagnosis</subject><subject>Brain Injuries - drug therapy</subject><subject>Brain Injuries - etiology</subject><subject>Brain Injuries - metabolism</subject><subject>Encephalitis - drug therapy</subject><subject>Evans Blue</subject><subject>Extravasation of Diagnostic and Therapeutic Materials</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Guanidines - administration & dosage</subject><subject>Guanidines - therapeutic use</subject><subject>Male</subject><subject>Neuroprotective Agents - administration & dosage</subject><subject>Neuroprotective Agents - therapeutic use</subject><subject>Neurosurgery</subject><subject>NF-kappa B - metabolism</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - metabolism</subject><subject>Surgical brain injury</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVp6G7S_oMS9tLevNHo25dCCE3aEgiE9Cxkebxo8cqJZAfy7yOzJr2llxl455lheAj5CnQLFNTFfhtx6nHcMkpNibaUmw9kDUazSteafSRryqmoeC3oipzmvKeUSpDiE1mBqYUBZdbkz_3Q42boNu4Q4rCbXAxtiLgJcdMkV-pjGkb0YxjinOUp7YJ3_TIMcT-ll3mQ3PiZnHSuz_hl6Wfk7_XPh6tf1e3dze-ry9vKCwZjJbT2ukEpnGQt79B1IDtQynSm9hRBK1Y3DQJzHJ3iArRhWjOOEjhXGvkZ-X68W157mjCP9hCyx753EYcpW1UbpoyG_4JQcy654QUUR9CnIeeEnX1M4eDSiwVqZ9l2b4-y7Sx7Tovssna-3J-aA7b_lha7Bfi2AC4XaV1y0Yf8xjFaS0WZLNyPI4dF23PAZLMPGD22IRX3th3C-5-8ApGSnk4</recordid><startdate>20081226</startdate><enddate>20081226</enddate><creator>Di, Fan</creator><creator>Yan-ting, Gu</creator><creator>Hui, Lv</creator><creator>Tao, Tang</creator><creator>Zai-hua, Xu</creator><creator>Xue-ying, Shi</creator><creator>Hong-li, Xue</creator><creator>Yun-jie, Wang</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20081226</creationdate><title>Role of aminoguanidine in brain protection in surgical brain injury in rat</title><author>Di, Fan ; Yan-ting, Gu ; Hui, Lv ; Tao, Tang ; Zai-hua, Xu ; Xue-ying, Shi ; Hong-li, Xue ; Yun-jie, Wang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-477c7be54a52d3feaf15f1668f89c0e17629bbe12a3ea63417827723e513367e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aminoguanidine</topic><topic>Animals</topic><topic>BBB</topic><topic>Biological and medical sciences</topic><topic>Blood-Brain Barrier - drug effects</topic><topic>Blood-Brain Barrier - physiopathology</topic><topic>Blotting, Western</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Brain - surgery</topic><topic>Brain Chemistry - drug effects</topic><topic>Brain edema</topic><topic>Brain Edema - drug therapy</topic><topic>Brain Edema - etiology</topic><topic>Brain Edema - metabolism</topic><topic>Brain Injuries - diagnosis</topic><topic>Brain Injuries - drug therapy</topic><topic>Brain Injuries - etiology</topic><topic>Brain Injuries - metabolism</topic><topic>Encephalitis - drug therapy</topic><topic>Evans Blue</topic><topic>Extravasation of Diagnostic and Therapeutic Materials</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Guanidines - administration & dosage</topic><topic>Guanidines - therapeutic use</topic><topic>Male</topic><topic>Neuroprotective Agents - administration & dosage</topic><topic>Neuroprotective Agents - therapeutic use</topic><topic>Neurosurgery</topic><topic>NF-kappa B - metabolism</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - metabolism</topic><topic>Surgical brain injury</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Di, Fan</creatorcontrib><creatorcontrib>Yan-ting, Gu</creatorcontrib><creatorcontrib>Hui, Lv</creatorcontrib><creatorcontrib>Tao, Tang</creatorcontrib><creatorcontrib>Zai-hua, Xu</creatorcontrib><creatorcontrib>Xue-ying, Shi</creatorcontrib><creatorcontrib>Hong-li, Xue</creatorcontrib><creatorcontrib>Yun-jie, Wang</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Di, Fan</au><au>Yan-ting, Gu</au><au>Hui, Lv</au><au>Tao, Tang</au><au>Zai-hua, Xu</au><au>Xue-ying, Shi</au><au>Hong-li, Xue</au><au>Yun-jie, Wang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of aminoguanidine in brain protection in surgical brain injury in rat</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2008-12-26</date><risdate>2008</risdate><volume>448</volume><issue>2</issue><spage>204</spage><epage>207</epage><pages>204-207</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>The study investigated the effect of aminoguanidine (AG) on surgical brain injury (SBI) in rat. AG (75, 150 and 300
mg/kg, i.p.) was administered immediately following surgical resection. Using a SBI model, we found that AG (150
mg/kg) significantly reduced cerebral edema, while AG at the doses of 75 and 300
mg/kg had no effect. And AG (150
mg/kg) significantly reduced Evans Blue extravasation into brain tissue and improved the neurological outcome compared to control group. Moreover, the expression of TNF-α and nuclear factor-κB (NF-κB) mRNA and protein in brain tissue at the edge of the resection site increased at 24
h after SBI, which could be significantly attenuated by the treatment with AG via RT-PCR and Western blots methods. Our results demonstrated that SBI causes increased brain edema, BBB disruption and inflammation along the periphery of the site of surgical resection, which could be significantly improved by the treatment of AG.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>18948168</pmid><doi>10.1016/j.neulet.2008.10.038</doi><tpages>4</tpages></addata></record> |
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| ispartof | Neuroscience letters, 2008-12, Vol.448 (2), p.204-207 |
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| subjects | Aminoguanidine Animals BBB Biological and medical sciences Blood-Brain Barrier - drug effects Blood-Brain Barrier - physiopathology Blotting, Western Brain - drug effects Brain - metabolism Brain - surgery Brain Chemistry - drug effects Brain edema Brain Edema - drug therapy Brain Edema - etiology Brain Edema - metabolism Brain Injuries - diagnosis Brain Injuries - drug therapy Brain Injuries - etiology Brain Injuries - metabolism Encephalitis - drug therapy Evans Blue Extravasation of Diagnostic and Therapeutic Materials Fundamental and applied biological sciences. Psychology Guanidines - administration & dosage Guanidines - therapeutic use Male Neuroprotective Agents - administration & dosage Neuroprotective Agents - therapeutic use Neurosurgery NF-kappa B - metabolism Random Allocation Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Surgical brain injury Tumor Necrosis Factor-alpha - metabolism Vertebrates: nervous system and sense organs |
| title | Role of aminoguanidine in brain protection in surgical brain injury in rat |
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