Development and validation of a rapid, sensitive liquid chromatography–tandem mass spectrometry method using electrospray ionization for quantitation of centchroman in rat plasma and its application to preclinical pharmacokinetic study

A highly sensitive and specific HPLC–ESI-MS/MS method has been developed and validated for the estimation of centchroman with 100 μL rat plasma using tamoxifen as an internal standard (IS). The assay procedure involved a single-step, liquid–liquid extraction of centchroman and IS from plasma with 2....

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2008-12, Vol.876 (1), p.1-7
Hauptverfasser:	Singh, Sheelendra Pratap, Singh, Ravi Shankar Prasad, Wahajuddin, Jain, Girish Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Centchroman Centchroman - blood Centchroman - pharmacokinetics Chromatography, High Pressure Liquid - methods Drug Stability Female Fundamental and applied biological sciences. Psychology General pharmacology LC–MS/MS Medical sciences Pharmacokinetics Pharmacology. Drug treatments Rat plasma Rats Rats, Sprague-Dawley Reproducibility of Results Sensitivity and Specificity Spectrometry, Mass, Electrospray Ionization - methods Tandem Mass Spectrometry - methods Validation
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