Free radical involvement in endothelium-dependent responses of the rat thoracic aorta in moderate hypoxic conditions

This study investigates the effects of agents which act on the production or efficacy of free radicals on the hypoxic responses of rat aorta rings. Under moderate hypoxic conditions, the resting tension of the rings was not changed but in rings precontracted with 5-hydroxytryptamine, there was a rel...

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Veröffentlicht in:	European journal of pharmacology 1999-05, Vol.372 (1), p.57-63
Hauptverfasser:	Saı̈ag, Bernard, Shacoori, Valliolah, Bodin, Philippe, Pape, Daniel, Allain, Hervé, Burnstock, Geoffrey
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta, Thoracic - drug effects Aorta, Thoracic - physiology Atherosclerosis (general aspects, experimental research) Benzophenones - pharmacology Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Catalase - pharmacology Chelating Agents - pharmacology Constriction Deferoxamine - pharmacology Diuretics, Osmotic - pharmacology Endothelium Endothelium, Vascular - physiology Enzyme Inhibitors - pharmacology Free radical scavengers Free Radical Scavengers - pharmacology Free Radicals - metabolism Hypoxia Hypoxia - physiopathology In Vitro Techniques Male Mannitol - pharmacology Medical sciences NG-nitro- l-arginine methyl ester ( l-NAME) NG-Nitroarginine Methyl Ester - pharmacology Psychotropic Drugs - pharmacology Rats Rats, Wistar Relaxation Serotonin - pharmacology Superoxide Dismutase - pharmacology Thoracic aorta Vasoconstriction - drug effects Vasoconstriction - physiology Vasodilation - drug effects Vasodilation - physiology
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