Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

We carried out the first analysis of alternative splicing complexity in human tissues using mRNA-Seq data. New splice junctions were detected in ∼20% of multiexon genes, many of which are tissue specific. By combining mRNA-Seq and EST-cDNA sequence data, we estimate that transcripts from ∼95% of mul...

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Veröffentlicht in:	Nature genetics 2008-12, Vol.40 (12), p.1413-1415
Hauptverfasser:	Blencowe, Benjamin J, Pan, Qun, Shai, Ofer, Lee, Leo J, Frey, Brendan J
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Alternative Splicing Animal Genetics and Genomics Biological and medical sciences Biomedical and Life Sciences Biomedicine Brain brief-communication Cancer Research DNA microarrays DNA sequencing Estimates Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Profiling Gene Function Genetic engineering Genetics of eukaryotes. Biological and molecular evolution Human Genetics Humans Medical research Messenger RNA Methods Nucleotide sequencing Physiological aspects RNA Splice Sites RNA, Messenger Sequence Analysis, RNA - methods Studies Tissues
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