Determination of the inhibitory potential of 6 fluoroquinolones on CYP1A2 and CYP2C9 in human liver microsomes

Aim: To determine the inhibitory potential of 2 new fluoroquinolones, caderofloxacin and antofloxacin, together with 4 marketed fluoroquinolones, moxifloxacin, gatifloxacin, levofloxacin, and ciprofloxacin, on the activity of cytochrome P450 isoforms 1A2 (CYP1A2) and 2C9 (CYP2C9). Methods: Probe sub...

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Veröffentlicht in:	Acta pharmacologica Sinica 2008-12, Vol.29 (12), p.1507-1514
Hauptverfasser:	Zhang, Li, Wei, Min-ji, Zhao, Cai-yun, Qi, Hui-min
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Infective Agents - pharmacology Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors Aryl Hydrocarbon Hydroxylases - metabolism Aza Compounds - pharmacology Biomedical and Life Sciences Biomedicine Ciprofloxacin - pharmacology Cytochrome P-450 CYP1A2 - metabolism Cytochrome P-450 CYP1A2 Inhibitors Cytochrome P-450 CYP2C9 cytochrome P450 enzyme fluoroquinolone Fluoroquinolones - pharmacology Humans Immunology Internal Medicine Isoenzymes - antagonists & inhibitors Isoenzymes - metabolism Levofloxacin liquid chromatography/mass spectrometry liver microsome Medical Microbiology Microsomes, Liver - drug effects Microsomes, Liver - enzymology Molecular Structure Ofloxacin - analogs & derivatives Ofloxacin - pharmacology original-article Pharmacology/Toxicology Quinolines - pharmacology Reproducibility of Results Vaccine
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