Cerebrospinal fluid outflow: An evolving perspective
Abstract Cerebrospinal fluid (CSF) serves numerous important functions in the central nervous system. Despite numerous reports characterizing CSF and its circulation in the subarachnoid space, our understanding of CSF outflow remains limited. Although initial work suggested that both arachnoid granu...
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| Veröffentlicht in: | Brain research bulletin 2008-12, Vol.77 (6), p.327-334 |
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| creator | Kapoor, Kapil G Katz, Steven E Grzybowski, Deborah M Lubow, Martin |
| description | Abstract Cerebrospinal fluid (CSF) serves numerous important functions in the central nervous system. Despite numerous reports characterizing CSF and its circulation in the subarachnoid space, our understanding of CSF outflow remains limited. Although initial work suggested that both arachnoid granulations and lymphatic capillaries shared in the role of CSF outflow, predominant work since then has focused on the arachnoid granulations. A growing body of recent evidence not only suggests the importance of both arachnoid granulations and lymphatic capillaries, but also additional contributions through transependymal passage likely share in the role of CSF outflow. Consideration of all mechanisms and pathways will help us to better understand the significance of CSF outflow, in health and disease. Here we review how the present concept of CSF outflow has evolved, including a historical review of significant findings and a discussion of the latest innovative developments. |
| doi_str_mv | 10.1016/j.brainresbull.2008.08.009 |
| format | Article |
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Despite numerous reports characterizing CSF and its circulation in the subarachnoid space, our understanding of CSF outflow remains limited. Although initial work suggested that both arachnoid granulations and lymphatic capillaries shared in the role of CSF outflow, predominant work since then has focused on the arachnoid granulations. A growing body of recent evidence not only suggests the importance of both arachnoid granulations and lymphatic capillaries, but also additional contributions through transependymal passage likely share in the role of CSF outflow. Consideration of all mechanisms and pathways will help us to better understand the significance of CSF outflow, in health and disease. Here we review how the present concept of CSF outflow has evolved, including a historical review of significant findings and a discussion of the latest innovative developments.</description><subject>Animals</subject><subject>Arachnoid - anatomy & histology</subject><subject>Arachnoid - metabolism</subject><subject>Arachnoid granulation</subject><subject>Biological Transport - physiology</subject><subject>Cerebrospinal fluid</subject><subject>Cerebrospinal Fluid - physiology</subject><subject>Egress</subject><subject>Endothelium - cytology</subject><subject>Endothelium - metabolism</subject><subject>Granulation Tissue - metabolism</subject><subject>Humans</subject><subject>Lymphatic</subject><subject>Lymphatic System - metabolism</subject><subject>Lymphatic System - physiology</subject><subject>Lymphatic Vessels - physiology</subject><subject>Neurology</subject><subject>Outflow</subject><issn>0361-9230</issn><issn>1873-2747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1r3DAQhkVJ6G7S_oVicsjNm5FkW_IeAsu2-YBADm2hNyHL46KN1nYke8P--8rsQkMuCQzo8mhe5nkJuaCwoECLq82i8tq2HkM1OrdgAHIxDZSfyJxKwVMmMnFC5sALmpaMw4ychbABgELmxWcyi1DJBfA5ydbosfJd6G2rXdK40dZJNw6N616WyapNcNe5nW3_Jj360KMZ7A6_kNNGu4Bfj-85-X3z49f6Ln14vL1frx5SkxXZkEomNdUCRKXLDHhTV0I2rBKcZpVgDEvDC8ObvNRc6tywrNayFgw4ZbqWAvk5uTzs7X33PGIY1NYGg87pFrsxqKKUjBbxlPdAWuaUcZpHcHkATTw5eGxU7-1W-72ioCa5aqNey1WTXDUNTCnfjiljtcX6_9ejzQh8PwAYpewsehWMxdZgbX00p-rOfizn-s0a42xrjXZPuMew6UYfu4pXqcAUqJ9TzVPLIAGYyP_wfwKnpnQ</recordid><startdate>20081216</startdate><enddate>20081216</enddate><creator>Kapoor, Kapil G</creator><creator>Katz, Steven E</creator><creator>Grzybowski, Deborah M</creator><creator>Lubow, Martin</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20081216</creationdate><title>Cerebrospinal fluid outflow: An evolving perspective</title><author>Kapoor, Kapil G ; Katz, Steven E ; Grzybowski, Deborah M ; Lubow, Martin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-828a1a707ba9403fdb78f2b7314b722e9c36c3f59a38a5c24da8d720312ad87e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Arachnoid - anatomy & histology</topic><topic>Arachnoid - metabolism</topic><topic>Arachnoid granulation</topic><topic>Biological Transport - physiology</topic><topic>Cerebrospinal fluid</topic><topic>Cerebrospinal Fluid - physiology</topic><topic>Egress</topic><topic>Endothelium - cytology</topic><topic>Endothelium - metabolism</topic><topic>Granulation Tissue - metabolism</topic><topic>Humans</topic><topic>Lymphatic</topic><topic>Lymphatic System - metabolism</topic><topic>Lymphatic System - physiology</topic><topic>Lymphatic Vessels - physiology</topic><topic>Neurology</topic><topic>Outflow</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kapoor, Kapil G</creatorcontrib><creatorcontrib>Katz, Steven E</creatorcontrib><creatorcontrib>Grzybowski, Deborah M</creatorcontrib><creatorcontrib>Lubow, Martin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kapoor, Kapil G</au><au>Katz, Steven E</au><au>Grzybowski, Deborah M</au><au>Lubow, Martin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebrospinal fluid outflow: An evolving perspective</atitle><jtitle>Brain research bulletin</jtitle><addtitle>Brain Res Bull</addtitle><date>2008-12-16</date><risdate>2008</risdate><volume>77</volume><issue>6</issue><spage>327</spage><epage>334</epage><pages>327-334</pages><issn>0361-9230</issn><eissn>1873-2747</eissn><abstract>Abstract Cerebrospinal fluid (CSF) serves numerous important functions in the central nervous system. 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| ispartof | Brain research bulletin, 2008-12, Vol.77 (6), p.327-334 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Arachnoid - anatomy & histology Arachnoid - metabolism Arachnoid granulation Biological Transport - physiology Cerebrospinal fluid Cerebrospinal Fluid - physiology Egress Endothelium - cytology Endothelium - metabolism Granulation Tissue - metabolism Humans Lymphatic Lymphatic System - metabolism Lymphatic System - physiology Lymphatic Vessels - physiology Neurology Outflow |
| title | Cerebrospinal fluid outflow: An evolving perspective |
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