Cannabidiol prevents a post-ischemic injury progressively induced by cerebral ischemia via a high-mobility group box1-inhibiting mechanism

We examined the cerebroprotective mechanism of cannabidiol, the non-psychoactive component of marijuana, against infarction in a 4-h mouse middle cerebral artery (MCA) occlusion model. Cannabidiol was intraperitoneally administrated immediately before and 3h after cerebral ischemia. Infarct size and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuropharmacology 2008-12, Vol.55 (8), p.1280-1286
Hauptverfasser:	Hayakawa, Kazuhide, Mishima, Kenichi, Irie, Keiichi, Hazekawa, Mai, Mishima, Shohei, Fujioka, Masayuki, Orito, Kensuke, Egashira, Nobuaki, Katsurabayashi, Shutaro, Takasaki, Kotaro, Iwasaki, Katsunori, Fujiwara, Michihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Blood Pressure - physiology Brain Injuries - etiology Brain Injuries - prevention & control Calcium-Binding Proteins - metabolism Cannabidiol Cannabidiol - therapeutic use Cerebral ischemia Disease Models, Animal Disease Progression Dose-Response Relationship, Drug Gene Expression Regulation - drug effects Glial Fibrillary Acidic Protein - metabolism High-mobility group box1 HMGB1 Protein - metabolism In Situ Nick-End Labeling - methods Infarction, Middle Cerebral Artery - complications Male Mice Microfilament Proteins Motor Activity - physiology Myeloperoxidase Neurologic Examination Peroxidase - metabolism Phosphopyruvate Hydratase - metabolism Reperfusion Tetrazolium Salts Time Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!