Mnestic Block Syndrome
The case of a patient with largely preserved intelligence, but severe and persistent memory impairments is reported. FA, a 46-year-old patient with the diagnosis of prolonged depression was investigated repeatedly over a two year period with neuroradiological, neuropsychological, neuromonitoring and...
Gespeichert in:
| Veröffentlicht in: | Cortex 1999-04, Vol.35 (2), p.219-230 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 230 |
|---|---|
| container_issue | 2 |
| container_start_page | 219 |
| container_title | Cortex |
| container_volume | 35 |
| creator | Markowitsch, Hans J. Kessler, Josef Russ, Michael O. Frölich, Lutz Schneider, Barbara Maurer, Konrad |
| description | The case of a patient with largely preserved intelligence, but severe and persistent memory impairments is reported. FA, a 46-year-old patient with the diagnosis of prolonged depression was investigated repeatedly over a two year period with neuroradiological, neuropsychological, neuromonitoring and other methods. While no brain damage was detectable in FA, he manifested continued and severe anterograde and retrograde memory disorders together with an inhibition in his thinking processes. Otherwise, his intellectual capabilities were in the normal range, that is he was not pseudo-demented. Various approaches with drug treatment and psychotherapy failed to improve his condition. The condition is interpreted as ‘mnestic block syndrome’ and is considered to be related to an altered brain metabolism which may include changes in various transmitter and hormonal systems (GABA-agonists, glucocorticoids, acetylcholine). Whether depression contributes to this syndrome is uncertain from FA's cognitive performance, but may be a possibility. |
| doi_str_mv | 10.1016/S0010-9452(08)70795-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69820252</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0010945208707950</els_id><sourcerecordid>69820252</sourcerecordid><originalsourceid>FETCH-LOGICAL-c361t-b5f2528469788346c6828cdda34fae31cae0f194e3a4f25749a8e9d5705e33cb3</originalsourceid><addsrcrecordid>eNqFkLtOAzEQRS0EIiHQ0oGoEBQL49euXSGIeElBFIHacryzkmEfwU6Q8vc42QjRUU1z7tyZQ8gJhSsKNL-eAlDItJDsAtRlAYWWGeyQIdUFzxQFtkuGv8iAHMT4AcBASblPBhR4rkGLITl-aTEuvDu7qzv3eTZdtWXoGjwke5WtIx5t54i8P9y_jZ-yyevj8_h2kjme00U2kxWTTIlcF0pxkbtcMeXK0nJRWeTUWYSKaoHcikQWQluFupQFSOTczfiInPd756H7WqZLTOOjw7q2LXbLaHKtGKSKBMoedKGLMWBl5sE3NqwMBbMWYjZCzPpbA8pshBhIudNtwXLWYPkn1RtIwE0PYHrz22Mw0XlsHZY-oFuYsvP_VPwACKxtTQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69820252</pqid></control><display><type>article</type><title>Mnestic Block Syndrome</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Markowitsch, Hans J. ; Kessler, Josef ; Russ, Michael O. ; Frölich, Lutz ; Schneider, Barbara ; Maurer, Konrad</creator><creatorcontrib>Markowitsch, Hans J. ; Kessler, Josef ; Russ, Michael O. ; Frölich, Lutz ; Schneider, Barbara ; Maurer, Konrad</creatorcontrib><description>The case of a patient with largely preserved intelligence, but severe and persistent memory impairments is reported. FA, a 46-year-old patient with the diagnosis of prolonged depression was investigated repeatedly over a two year period with neuroradiological, neuropsychological, neuromonitoring and other methods. While no brain damage was detectable in FA, he manifested continued and severe anterograde and retrograde memory disorders together with an inhibition in his thinking processes. Otherwise, his intellectual capabilities were in the normal range, that is he was not pseudo-demented. Various approaches with drug treatment and psychotherapy failed to improve his condition. The condition is interpreted as ‘mnestic block syndrome’ and is considered to be related to an altered brain metabolism which may include changes in various transmitter and hormonal systems (GABA-agonists, glucocorticoids, acetylcholine). Whether depression contributes to this syndrome is uncertain from FA's cognitive performance, but may be a possibility.</description><identifier>ISSN: 0010-9452</identifier><identifier>EISSN: 1973-8102</identifier><identifier>DOI: 10.1016/S0010-9452(08)70795-0</identifier><identifier>PMID: 10369094</identifier><language>eng</language><publisher>Italy: Elsevier Srl</publisher><subject>amnesia ; Amnesia, Retrograde - psychology ; depression ; Depressive Disorder - diagnostic imaging ; Depressive Disorder - pathology ; Depressive Disorder - psychology ; Electroencephalography ; Humans ; Intelligence - physiology ; Magnetic Resonance Imaging ; Male ; Memory Disorders - diagnostic imaging ; Memory Disorders - pathology ; Memory Disorders - psychology ; Middle Aged ; MMPI ; Neuropsychological Tests ; neurotransmitters ; Psychiatric Status Rating Scales ; Syndrome ; Tomography, Emission-Computed ; Tomography, Emission-Computed, Single-Photon</subject><ispartof>Cortex, 1999-04, Vol.35 (2), p.219-230</ispartof><rights>1999 Elsevier Masson Srl</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-b5f2528469788346c6828cdda34fae31cae0f194e3a4f25749a8e9d5705e33cb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0010-9452(08)70795-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10369094$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Markowitsch, Hans J.</creatorcontrib><creatorcontrib>Kessler, Josef</creatorcontrib><creatorcontrib>Russ, Michael O.</creatorcontrib><creatorcontrib>Frölich, Lutz</creatorcontrib><creatorcontrib>Schneider, Barbara</creatorcontrib><creatorcontrib>Maurer, Konrad</creatorcontrib><title>Mnestic Block Syndrome</title><title>Cortex</title><addtitle>Cortex</addtitle><description>The case of a patient with largely preserved intelligence, but severe and persistent memory impairments is reported. FA, a 46-year-old patient with the diagnosis of prolonged depression was investigated repeatedly over a two year period with neuroradiological, neuropsychological, neuromonitoring and other methods. While no brain damage was detectable in FA, he manifested continued and severe anterograde and retrograde memory disorders together with an inhibition in his thinking processes. Otherwise, his intellectual capabilities were in the normal range, that is he was not pseudo-demented. Various approaches with drug treatment and psychotherapy failed to improve his condition. The condition is interpreted as ‘mnestic block syndrome’ and is considered to be related to an altered brain metabolism which may include changes in various transmitter and hormonal systems (GABA-agonists, glucocorticoids, acetylcholine). Whether depression contributes to this syndrome is uncertain from FA's cognitive performance, but may be a possibility.</description><subject>amnesia</subject><subject>Amnesia, Retrograde - psychology</subject><subject>depression</subject><subject>Depressive Disorder - diagnostic imaging</subject><subject>Depressive Disorder - pathology</subject><subject>Depressive Disorder - psychology</subject><subject>Electroencephalography</subject><subject>Humans</subject><subject>Intelligence - physiology</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Memory Disorders - diagnostic imaging</subject><subject>Memory Disorders - pathology</subject><subject>Memory Disorders - psychology</subject><subject>Middle Aged</subject><subject>MMPI</subject><subject>Neuropsychological Tests</subject><subject>neurotransmitters</subject><subject>Psychiatric Status Rating Scales</subject><subject>Syndrome</subject><subject>Tomography, Emission-Computed</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><issn>0010-9452</issn><issn>1973-8102</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkLtOAzEQRS0EIiHQ0oGoEBQL49euXSGIeElBFIHacryzkmEfwU6Q8vc42QjRUU1z7tyZQ8gJhSsKNL-eAlDItJDsAtRlAYWWGeyQIdUFzxQFtkuGv8iAHMT4AcBASblPBhR4rkGLITl-aTEuvDu7qzv3eTZdtWXoGjwke5WtIx5t54i8P9y_jZ-yyevj8_h2kjme00U2kxWTTIlcF0pxkbtcMeXK0nJRWeTUWYSKaoHcikQWQluFupQFSOTczfiInPd756H7WqZLTOOjw7q2LXbLaHKtGKSKBMoedKGLMWBl5sE3NqwMBbMWYjZCzPpbA8pshBhIudNtwXLWYPkn1RtIwE0PYHrz22Mw0XlsHZY-oFuYsvP_VPwACKxtTQ</recordid><startdate>19990401</startdate><enddate>19990401</enddate><creator>Markowitsch, Hans J.</creator><creator>Kessler, Josef</creator><creator>Russ, Michael O.</creator><creator>Frölich, Lutz</creator><creator>Schneider, Barbara</creator><creator>Maurer, Konrad</creator><general>Elsevier Srl</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>19990401</creationdate><title>Mnestic Block Syndrome</title><author>Markowitsch, Hans J. ; Kessler, Josef ; Russ, Michael O. ; Frölich, Lutz ; Schneider, Barbara ; Maurer, Konrad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-b5f2528469788346c6828cdda34fae31cae0f194e3a4f25749a8e9d5705e33cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>amnesia</topic><topic>Amnesia, Retrograde - psychology</topic><topic>depression</topic><topic>Depressive Disorder - diagnostic imaging</topic><topic>Depressive Disorder - pathology</topic><topic>Depressive Disorder - psychology</topic><topic>Electroencephalography</topic><topic>Humans</topic><topic>Intelligence - physiology</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Memory Disorders - diagnostic imaging</topic><topic>Memory Disorders - pathology</topic><topic>Memory Disorders - psychology</topic><topic>Middle Aged</topic><topic>MMPI</topic><topic>Neuropsychological Tests</topic><topic>neurotransmitters</topic><topic>Psychiatric Status Rating Scales</topic><topic>Syndrome</topic><topic>Tomography, Emission-Computed</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Markowitsch, Hans J.</creatorcontrib><creatorcontrib>Kessler, Josef</creatorcontrib><creatorcontrib>Russ, Michael O.</creatorcontrib><creatorcontrib>Frölich, Lutz</creatorcontrib><creatorcontrib>Schneider, Barbara</creatorcontrib><creatorcontrib>Maurer, Konrad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Cortex</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Markowitsch, Hans J.</au><au>Kessler, Josef</au><au>Russ, Michael O.</au><au>Frölich, Lutz</au><au>Schneider, Barbara</au><au>Maurer, Konrad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mnestic Block Syndrome</atitle><jtitle>Cortex</jtitle><addtitle>Cortex</addtitle><date>1999-04-01</date><risdate>1999</risdate><volume>35</volume><issue>2</issue><spage>219</spage><epage>230</epage><pages>219-230</pages><issn>0010-9452</issn><eissn>1973-8102</eissn><abstract>The case of a patient with largely preserved intelligence, but severe and persistent memory impairments is reported. FA, a 46-year-old patient with the diagnosis of prolonged depression was investigated repeatedly over a two year period with neuroradiological, neuropsychological, neuromonitoring and other methods. While no brain damage was detectable in FA, he manifested continued and severe anterograde and retrograde memory disorders together with an inhibition in his thinking processes. Otherwise, his intellectual capabilities were in the normal range, that is he was not pseudo-demented. Various approaches with drug treatment and psychotherapy failed to improve his condition. The condition is interpreted as ‘mnestic block syndrome’ and is considered to be related to an altered brain metabolism which may include changes in various transmitter and hormonal systems (GABA-agonists, glucocorticoids, acetylcholine). Whether depression contributes to this syndrome is uncertain from FA's cognitive performance, but may be a possibility.</abstract><cop>Italy</cop><pub>Elsevier Srl</pub><pmid>10369094</pmid><doi>10.1016/S0010-9452(08)70795-0</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0010-9452 |
| ispartof | Cortex, 1999-04, Vol.35 (2), p.219-230 |
| issn | 0010-9452 1973-8102 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69820252 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | amnesia Amnesia, Retrograde - psychology depression Depressive Disorder - diagnostic imaging Depressive Disorder - pathology Depressive Disorder - psychology Electroencephalography Humans Intelligence - physiology Magnetic Resonance Imaging Male Memory Disorders - diagnostic imaging Memory Disorders - pathology Memory Disorders - psychology Middle Aged MMPI Neuropsychological Tests neurotransmitters Psychiatric Status Rating Scales Syndrome Tomography, Emission-Computed Tomography, Emission-Computed, Single-Photon |
| title | Mnestic Block Syndrome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T06%3A52%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mnestic%20Block%20Syndrome&rft.jtitle=Cortex&rft.au=Markowitsch,%20Hans%20J.&rft.date=1999-04-01&rft.volume=35&rft.issue=2&rft.spage=219&rft.epage=230&rft.pages=219-230&rft.issn=0010-9452&rft.eissn=1973-8102&rft_id=info:doi/10.1016/S0010-9452(08)70795-0&rft_dat=%3Cproquest_cross%3E69820252%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69820252&rft_id=info:pmid/10369094&rft_els_id=S0010945208707950&rfr_iscdi=true |