Strain Differences in Neointimal Hyperplasia in the Rat

We performed an initial screen of 11 rat strains by use of a standard balloon injury to the left iliac artery to observe whether genetically determined differences existed in the development of neointimal hyperplasia. Neointimal hyperplasia was assayed 8 weeks after the vascular injury on coded micr...

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Veröffentlicht in:	Circulation research 1999-06, Vol.84 (11), p.1252-1257
Hauptverfasser:	Assadnia, Shahin, Rapp, John P, Nestor, Andrea L, Pringle, Timothy, Cerilli, Greg J, Gunning, William T, Webb, Thomas H, Kligman, Mark, Allison, David C
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Biological and medical sciences Genetic Linkage Genome Hyperplasia Hypertension - pathology Iliac Artery - injuries Medical sciences Rats Rats, Inbred BN Rats, Inbred SHR Species Specificity Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Tunica Intima - pathology
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Zusammenfassung:	We performed an initial screen of 11 rat strains by use of a standard balloon injury to the left iliac artery to observe whether genetically determined differences existed in the development of neointimal hyperplasia. Neointimal hyperplasia was assayed 8 weeks after the vascular injury on coded microscopic sections. Statistically significant differences in the percentages of the vascular wall cross-sectional areas composed of intima (percentage intima) secondary to neointimal hyperplasia were noted among the different rat strains (P
ISSN:	0009-7330 1524-4571
DOI:	10.1161/01.RES.84.11.1252