Behavioral neurochemistry reveals a new functional dichotomy in the shell subregion of the nucleus accumbens
1. 1. The behavioral and neurochemical effects produced by the direct infusion of amphetamine by reverse microdialysis into either the core or shell of the nucleus accumbens were studied across the anteroposterior axis of this nucleus. 2. 2. Amphetamine (0. 05; 0. 10; 0. 50; 1. 00 μM) produced a dos...
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| Veröffentlicht in: | Progress in neuro-psychopharmacology & biological psychiatry 1999, Vol.23 (1), p.99-132 |
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| container_title | Progress in neuro-psychopharmacology & biological psychiatry |
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| creator | Heidbreder, Christian A. Hedou, Gael Feldon, Joram |
| description | 1.
1. The behavioral and neurochemical effects produced by the direct infusion of amphetamine by reverse microdialysis into either the core or shell of the nucleus accumbens were studied across the anteroposterior axis of this nucleus.
2.
2. Amphetamine (0. 05; 0. 10; 0. 50; 1. 00 μM) produced a dose-dependent increase i n locomotor activity after microinfusion into either the rostral shell, caudal shell or core of the nucleus accumbens. However, the amphetamine-induced locomotor activating effect was significantly higher in the rostral shell of the nucleus accumbens compared with both the caudal shell and core.
3.
3. The lowest concentrations of amphetamine produced an equipotent decrease in dialysate dopamine in either the rostral shell, caudal shell, or core. At 1. 0 μM, however, amphetamine selectively increased dopamine in the rostral shell. In contrast, the highest dose of amphetamine significantly increased dialysate serotonin levels over baseline only in the caudal shell of the nucleus accumbens.
4.
4. These results demonstrate the preferential effect of amphetamine on dopamine in the rostral shell and serotonin in the caudal shell subterritory of the nucleus accumbens. |
| doi_str_mv | 10.1016/S0278-5846(98)00094-3 |
| format | Article |
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1. The behavioral and neurochemical effects produced by the direct infusion of amphetamine by reverse microdialysis into either the core or shell of the nucleus accumbens were studied across the anteroposterior axis of this nucleus.
2.
2. Amphetamine (0. 05; 0. 10; 0. 50; 1. 00 μM) produced a dose-dependent increase i n locomotor activity after microinfusion into either the rostral shell, caudal shell or core of the nucleus accumbens. However, the amphetamine-induced locomotor activating effect was significantly higher in the rostral shell of the nucleus accumbens compared with both the caudal shell and core.
3.
3. The lowest concentrations of amphetamine produced an equipotent decrease in dialysate dopamine in either the rostral shell, caudal shell, or core. At 1. 0 μM, however, amphetamine selectively increased dopamine in the rostral shell. In contrast, the highest dose of amphetamine significantly increased dialysate serotonin levels over baseline only in the caudal shell of the nucleus accumbens.
4.
4. These results demonstrate the preferential effect of amphetamine on dopamine in the rostral shell and serotonin in the caudal shell subterritory of the nucleus accumbens.</description><identifier>ISSN: 0278-5846</identifier><identifier>EISSN: 1878-4216</identifier><identifier>DOI: 10.1016/S0278-5846(98)00094-3</identifier><identifier>PMID: 10368859</identifier><identifier>CODEN: PNPPD7</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>amphetamine ; Amphetamine - administration & dosage ; Amphetamine - pharmacology ; Analysis of Variance ; Animals ; Biological and medical sciences ; core ; dopamine ; Dopamine - analysis ; Dopamine Uptake Inhibitors - administration & dosage ; Dopamine Uptake Inhibitors - pharmacology ; Male ; Medical sciences ; microdialysis ; Motor Activity - drug effects ; Neuropharmacology ; nucleus accumbens ; Nucleus Accumbens - anatomy & histology ; Nucleus Accumbens - chemistry ; Nucleus Accumbens - drug effects ; Pharmacology. Drug treatments ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Rats ; Rats, Wistar ; serotonin ; Serotonin - analysis ; shell</subject><ispartof>Progress in neuro-psychopharmacology & biological psychiatry, 1999, Vol.23 (1), p.99-132</ispartof><rights>1999</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-e48d658037ab25426baae5f16bdefd35d24ffc82241ab027ee2fee8671f37ed73</citedby><cites>FETCH-LOGICAL-c421t-e48d658037ab25426baae5f16bdefd35d24ffc82241ab027ee2fee8671f37ed73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0278-5846(98)00094-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,4022,27922,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1693647$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10368859$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heidbreder, Christian A.</creatorcontrib><creatorcontrib>Hedou, Gael</creatorcontrib><creatorcontrib>Feldon, Joram</creatorcontrib><title>Behavioral neurochemistry reveals a new functional dichotomy in the shell subregion of the nucleus accumbens</title><title>Progress in neuro-psychopharmacology & biological psychiatry</title><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><description>1.
1. The behavioral and neurochemical effects produced by the direct infusion of amphetamine by reverse microdialysis into either the core or shell of the nucleus accumbens were studied across the anteroposterior axis of this nucleus.
2.
2. Amphetamine (0. 05; 0. 10; 0. 50; 1. 00 μM) produced a dose-dependent increase i n locomotor activity after microinfusion into either the rostral shell, caudal shell or core of the nucleus accumbens. However, the amphetamine-induced locomotor activating effect was significantly higher in the rostral shell of the nucleus accumbens compared with both the caudal shell and core.
3.
3. The lowest concentrations of amphetamine produced an equipotent decrease in dialysate dopamine in either the rostral shell, caudal shell, or core. At 1. 0 μM, however, amphetamine selectively increased dopamine in the rostral shell. In contrast, the highest dose of amphetamine significantly increased dialysate serotonin levels over baseline only in the caudal shell of the nucleus accumbens.
4.
4. These results demonstrate the preferential effect of amphetamine on dopamine in the rostral shell and serotonin in the caudal shell subterritory of the nucleus accumbens.</description><subject>amphetamine</subject><subject>Amphetamine - administration & dosage</subject><subject>Amphetamine - pharmacology</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>core</subject><subject>dopamine</subject><subject>Dopamine - analysis</subject><subject>Dopamine Uptake Inhibitors - administration & dosage</subject><subject>Dopamine Uptake Inhibitors - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>microdialysis</subject><subject>Motor Activity - drug effects</subject><subject>Neuropharmacology</subject><subject>nucleus accumbens</subject><subject>Nucleus Accumbens - anatomy & histology</subject><subject>Nucleus Accumbens - chemistry</subject><subject>Nucleus Accumbens - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>serotonin</subject><subject>Serotonin - analysis</subject><subject>shell</subject><issn>0278-5846</issn><issn>1878-4216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1TAQhS1ERS-FnwDyAiFYBPxIHGdVQQUUqRILYG059pgYJXax41vdf4_vQ9BdV5bG35w5MwehF5S8o4SK998J62XTyVa8GeRbQsjQNvwR2lBZyy2j4jHa_EPO0dOcf1eIcsKfoHNKuJCyGzZo_giT3vqY9IwDlBTNBIvPa9rhBFvQc8a6ftxhV4JZfQyVs95McY3LDvuA1wlwnmCecS5jgl8VwdEdyqGYGUoVMKYsI4T8DJ25qgjPT-8F-vn504-r6-bm25evVx9uGlONrw200opOEt7rkXUtE6PW0DkqRgvO8s6y1jkjGWupHuuOAMwBSNFTx3uwPb9Ar4-6tyn-KZBXVVcy1aMOEEtWYpCs3pA-CNK-6wURe8XuCJoUc07g1G3yi047RYna56EOeaj9sdUg1SEPxWvfy9OAMi5g73UdA6jAqxOgs9GzSzoYn_9zYuCi3c-_PGJQz7b1kFQ2HoIB6xOYVdnoH3DyFxt2qXw</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>Heidbreder, Christian A.</creator><creator>Hedou, Gael</creator><creator>Feldon, Joram</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1999</creationdate><title>Behavioral neurochemistry reveals a new functional dichotomy in the shell subregion of the nucleus accumbens</title><author>Heidbreder, Christian A. ; Hedou, Gael ; Feldon, Joram</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-e48d658037ab25426baae5f16bdefd35d24ffc82241ab027ee2fee8671f37ed73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>amphetamine</topic><topic>Amphetamine - administration & dosage</topic><topic>Amphetamine - pharmacology</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>core</topic><topic>dopamine</topic><topic>Dopamine - analysis</topic><topic>Dopamine Uptake Inhibitors - administration & dosage</topic><topic>Dopamine Uptake Inhibitors - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>microdialysis</topic><topic>Motor Activity - drug effects</topic><topic>Neuropharmacology</topic><topic>nucleus accumbens</topic><topic>Nucleus Accumbens - anatomy & histology</topic><topic>Nucleus Accumbens - chemistry</topic><topic>Nucleus Accumbens - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>serotonin</topic><topic>Serotonin - analysis</topic><topic>shell</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heidbreder, Christian A.</creatorcontrib><creatorcontrib>Hedou, Gael</creatorcontrib><creatorcontrib>Feldon, Joram</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heidbreder, Christian A.</au><au>Hedou, Gael</au><au>Feldon, Joram</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Behavioral neurochemistry reveals a new functional dichotomy in the shell subregion of the nucleus accumbens</atitle><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><date>1999</date><risdate>1999</risdate><volume>23</volume><issue>1</issue><spage>99</spage><epage>132</epage><pages>99-132</pages><issn>0278-5846</issn><eissn>1878-4216</eissn><coden>PNPPD7</coden><abstract>1.
1. The behavioral and neurochemical effects produced by the direct infusion of amphetamine by reverse microdialysis into either the core or shell of the nucleus accumbens were studied across the anteroposterior axis of this nucleus.
2.
2. Amphetamine (0. 05; 0. 10; 0. 50; 1. 00 μM) produced a dose-dependent increase i n locomotor activity after microinfusion into either the rostral shell, caudal shell or core of the nucleus accumbens. However, the amphetamine-induced locomotor activating effect was significantly higher in the rostral shell of the nucleus accumbens compared with both the caudal shell and core.
3.
3. The lowest concentrations of amphetamine produced an equipotent decrease in dialysate dopamine in either the rostral shell, caudal shell, or core. At 1. 0 μM, however, amphetamine selectively increased dopamine in the rostral shell. In contrast, the highest dose of amphetamine significantly increased dialysate serotonin levels over baseline only in the caudal shell of the nucleus accumbens.
4.
4. These results demonstrate the preferential effect of amphetamine on dopamine in the rostral shell and serotonin in the caudal shell subterritory of the nucleus accumbens.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>10368859</pmid><doi>10.1016/S0278-5846(98)00094-3</doi><tpages>34</tpages></addata></record> |
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| subjects | amphetamine Amphetamine - administration & dosage Amphetamine - pharmacology Analysis of Variance Animals Biological and medical sciences core dopamine Dopamine - analysis Dopamine Uptake Inhibitors - administration & dosage Dopamine Uptake Inhibitors - pharmacology Male Medical sciences microdialysis Motor Activity - drug effects Neuropharmacology nucleus accumbens Nucleus Accumbens - anatomy & histology Nucleus Accumbens - chemistry Nucleus Accumbens - drug effects Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Wistar serotonin Serotonin - analysis shell |
| title | Behavioral neurochemistry reveals a new functional dichotomy in the shell subregion of the nucleus accumbens |
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