p53 transactivity during in vitro osteoblast differentiation in a rat osteosarcoma cell line

We previously demonstrated a correlation between wild‐type p53 expression and appearance of osteoblastic‐specific differentiation characteristics, as evidenced by basal osteocalcin gene expression in a mouse osteosarcoma tumor. The study reported here further explored the possibility of p53's h...

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Veröffentlicht in:	Molecular carcinogenesis 1999-06, Vol.25 (2), p.132-138
Hauptverfasser:	Schwartz, Karin A., Lanciloti, Natalie J., Moore, Michael K., Campione, Allan L., Chandar, Nalini
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers bone Cell Cycle - drug effects Cell Differentiation - genetics Chloramphenicol O-Acetyltransferase - genetics Cholecalciferol - pharmacology differentiation Genes, p53 Hydroxyurea - pharmacology Osteoblasts - metabolism Osteoblasts - pathology osteocalcin Osteocalcin - metabolism osteosarcoma Osteosarcoma - genetics Osteosarcoma - metabolism Osteosarcoma - pathology p53 Rats Transcription, Genetic - genetics Tumor Cells, Cultured Up-Regulation
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