Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

Notch proteins are cell surface receptors that mediate developmental cell specification events. To explore the function of murine Notch1, an essential portion of the gene was flanked with loxP sites and inactivation induced via interferon-regulated Cre recombinase. Mice with a neonatally induced los...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 1999-05, Vol.10 (5), p.547-558
Hauptverfasser:	Radtke, Freddy, Wilson, Anne, Stark, Gerlinde, Bauer, Michelle, van Meerwijk, Joost, MacDonald, H.Robson, Aguet, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn B-Lymphocytes - cytology CD4 Antigens - genetics CD8 Antigens - genetics Cell Differentiation - drug effects Cell Division - genetics Flow Cytometry Gene Expression Gene Expression Regulation Membrane Proteins - genetics Mice Mice, Transgenic Phenotype Receptor, Notch1 Receptors, Cell Surface T-Lymphocytes - cytology Thymus Gland - growth & development Transcription Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!