In vitro alpha1-adrenoceptor pharmacology of Ro 70-0004 and RS-100329, novel alpha1A-adrenoceptor selective antagonists

It has been hypothesized that in patients with benign prostatic hyperplasia, selective antagonism of the alpha1A-adrenoceptor-mediated contraction of lower urinary tract tissues may, via a selective relief of outlet obstruction, lead to an improvement in symptoms. The present study describes the alp...

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Veröffentlicht in:	British journal of pharmacology 1999-05, Vol.127 (1), p.252-258
Hauptverfasser:	Williams, T J, Blue, D R, Daniels, D V, Davis, B, Elworthy, T, Gever, J R, Kava, M S, Morgans, D, Padilla, F, Tassa, S, Vimont, R L, Chapple, C R, Chess-Williams, R, Eglen, R M, Clarke, D E, Ford, A P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-1 Receptor Antagonists Adrenergic alpha-Agonists - pharmacology Adrenergic alpha-Antagonists - pharmacology Animals CHO Cells Cloning, Molecular Cricetinae Humans In Vitro Techniques Inositol Phosphates - pharmacology Male Muscle, Smooth - drug effects Muscle, Smooth, Vascular - drug effects Norepinephrine - pharmacology Piperazines - pharmacology Prazosin - pharmacology Rabbits Radioligand Assay Rats Rats, Sprague-Dawley Receptors, Adrenergic, alpha-1 Sulfonamides - pharmacology Tamsulosin Thymine - analogs & derivatives Thymine - pharmacology Urinary Tract - metabolism
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