Short peptide nucleic acids (PNA) inhibit hepatitis C virus internal ribosome entry site (IRES) dependent translation in vitro

The internal ribosome entry site (IRES) of hepatitis C virus (HCV) which governs the initiation of protein synthesis from viral RNA represents an ideal target for antisense approaches. Using an original bicistronic plasmid, we first established that sequence and translational activity of HCV IRESs c...

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Veröffentlicht in:	Antiviral research 2008-12, Vol.80 (3), p.280-287
Hauptverfasser:	Alotte, Christine, Martin, Amaury, Caldarelli, Sergio A., Di Giorgio, Audrey, Condom, Roger, Zoulim, Fabien, Durantel, David, Hantz, Olivier
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antisense Antiviral agents Base Sequence Biological and medical sciences Cell Line DNA, Antisense - chemistry DNA, Antisense - genetics DNA, Antisense - pharmacology Down-Regulation - drug effects Hepacivirus - chemistry Hepacivirus - drug effects Hepacivirus - genetics Hepacivirus - metabolism Hepatitis C - drug therapy Hepatitis C - virology Hepatitis C virus Human viral diseases Humans Infectious diseases IRES JFH1 strain Medical sciences Molecular Sequence Data Peptide nucleic acid Peptide Nucleic Acids - chemistry Peptide Nucleic Acids - genetics Peptide Nucleic Acids - pharmacology Pharmacology. Drug treatments PNA Protein Biosynthesis - drug effects Rabbits Reticulocytes - metabolism Ribosomes - drug effects Ribosomes - genetics Ribosomes - metabolism Viral diseases Viral hepatitis
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