Angiotensin(1-7) Blunts Hypertensive Cardiac Remodeling by a Direct Effect on the Heart

Angiotensin-converting enzyme 2 (ACE2) converts the vasopressor angiotensin II (Ang II) into angiotensin (1-7) [Ang(1-7)], a peptide reported to have vasodilatory and cardioprotective properties. Inactivation of the ACE2 gene in mice has been reported by one group to result in an accumulation of Ang...

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Veröffentlicht in:	Circulation research 2008-11, Vol.103 (11), p.1319-1326
Hauptverfasser:	Mercure, Chantal, Yogi, Alvaro, Callera, Glaucia E, Aranha, Anna B, Bader, Michael, Ferreira, Anderson J, Santos, Robson A. S, Walther, Thomas, Touyz, Rhian M, Reudelhuber, Timothy L
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin I - pharmacology Angiotensin II - genetics Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Antihypertensive Agents - pharmacology Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Cardiology. Vascular system Cardiomegaly - enzymology Cardiomegaly - genetics Crosses, Genetic Fundamental and applied biological sciences. Psychology Heart - anatomy & histology Heart - drug effects Heart - physiology Heart - physiopathology Hypertension - prevention & control Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Myocardium - metabolism Myocardium - pathology Peptide Fragments - pharmacology Peptidyl-Dipeptidase A - pharmacology Renin-Angiotensin System - drug effects Ventricular Remodeling - drug effects Vertebrates: cardiovascular system
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