Host Response to Implanted Porcine-Derived Biologic Materials in a Primate Model of Abdominal Wall Repair
Three commercially available porcine-derived biologic meshes were implanted in an Old World primate abdominal wall resection repair model to compare biological outcome as a predictor of clinical efficacy. Tissues were explanted over a 6-month period and evaluated for gross pathology, wound healing s...
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| Veröffentlicht in: | Tissue engineering. Part A 2008-12, Vol.14 (12), p.221-2031 |
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| creator | Sandor, Maryellen Xu, Hui Connor, Jerome Lombardi, Jared Harper, John R. Silverman, Ronald P. McQuillan, David J. |
| description | Three commercially available porcine-derived biologic meshes were implanted in an Old World primate abdominal wall resection repair model to compare biological outcome as a predictor of clinical efficacy. Tissues were explanted over a 6-month period and evaluated for gross pathology, wound healing strength, mesenchymal cellular repopulation, vascularity, and immune response.
In vivo
functional outcomes were correlated with
in vitro
profile for each material. Small intestinal submucosa-based implants demonstrated scar tissue formation and contraction, coincident with mesh pleating, and were characterized by immediate and significant cellular and humoral inflammatory responses. Porcine dermal-based grafts demonstrated significant graft pleating, minimal integration, and an absence of cellular repopulation and vascularization. However, a significant cellular immune response surrounded the grafts, coincident with poor initial wound healing strengths.
In vivo
observations for the three porcine-derived mesh products correlated with individual
in vitro
profiles, indicating an absence of characteristic biochemical markers and structural integrity. This correlation suggests that
in vivo
results observed for these mesh products are a direct consequence of specific manufacturing processes that yield modified collagen matrices. The resulting loss of biological and structural integrity elicits a foreign body response while hindering normal healing and tissue integration. |
| doi_str_mv | 10.1089/ten.tea.2007.0317 |
| format | Article |
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In vivo
functional outcomes were correlated with
in vitro
profile for each material. Small intestinal submucosa-based implants demonstrated scar tissue formation and contraction, coincident with mesh pleating, and were characterized by immediate and significant cellular and humoral inflammatory responses. Porcine dermal-based grafts demonstrated significant graft pleating, minimal integration, and an absence of cellular repopulation and vascularization. However, a significant cellular immune response surrounded the grafts, coincident with poor initial wound healing strengths.
In vivo
observations for the three porcine-derived mesh products correlated with individual
in vitro
profiles, indicating an absence of characteristic biochemical markers and structural integrity. This correlation suggests that
in vivo
results observed for these mesh products are a direct consequence of specific manufacturing processes that yield modified collagen matrices. The resulting loss of biological and structural integrity elicits a foreign body response while hindering normal healing and tissue integration.</description><identifier>ISSN: 1937-3341</identifier><identifier>EISSN: 1937-335X</identifier><identifier>DOI: 10.1089/ten.tea.2007.0317</identifier><identifier>PMID: 18657025</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Abdomen ; Abdominal surgery ; Abdominal Wall - pathology ; Animals ; Antibodies ; Antibody Formation - immunology ; Biocompatible Materials - metabolism ; Biology ; Biomechanical Phenomena ; Biomedical materials ; Disease Models, Animal ; Hernia ; Implants, Experimental ; Muscles ; Physiological aspects ; Postoperative Care ; Primates ; Primates - immunology ; Prosthesis Implantation ; Surgery ; Sus scrofa - metabolism ; Tissue engineering ; Titrimetry ; Wound Healing</subject><ispartof>Tissue engineering. Part A, 2008-12, Vol.14 (12), p.221-2031</ispartof><rights>2008, Mary Ann Liebert, Inc.</rights><rights>COPYRIGHT 2008 Mary Ann Liebert, Inc.</rights><rights>(©) Copyright 2008, Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c537t-b8cc5f4acb70d6a1bc2ae63313021a8f5228cef1dc1c0ec2ed00fb048ee3ab873</citedby><cites>FETCH-LOGICAL-c537t-b8cc5f4acb70d6a1bc2ae63313021a8f5228cef1dc1c0ec2ed00fb048ee3ab873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.liebertpub.com/doi/epdf/10.1089/ten.tea.2007.0317$$EPDF$$P50$$Gmaryannliebert$$H</linktopdf><linktohtml>$$Uhttps://www.liebertpub.com/doi/full/10.1089/ten.tea.2007.0317$$EHTML$$P50$$Gmaryannliebert$$H</linktohtml><link.rule.ids>314,776,780,3029,21702,27901,27902,55266,55278</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18657025$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sandor, Maryellen</creatorcontrib><creatorcontrib>Xu, Hui</creatorcontrib><creatorcontrib>Connor, Jerome</creatorcontrib><creatorcontrib>Lombardi, Jared</creatorcontrib><creatorcontrib>Harper, John R.</creatorcontrib><creatorcontrib>Silverman, Ronald P.</creatorcontrib><creatorcontrib>McQuillan, David J.</creatorcontrib><title>Host Response to Implanted Porcine-Derived Biologic Materials in a Primate Model of Abdominal Wall Repair</title><title>Tissue engineering. Part A</title><addtitle>Tissue Eng Part A</addtitle><description>Three commercially available porcine-derived biologic meshes were implanted in an Old World primate abdominal wall resection repair model to compare biological outcome as a predictor of clinical efficacy. Tissues were explanted over a 6-month period and evaluated for gross pathology, wound healing strength, mesenchymal cellular repopulation, vascularity, and immune response.
In vivo
functional outcomes were correlated with
in vitro
profile for each material. Small intestinal submucosa-based implants demonstrated scar tissue formation and contraction, coincident with mesh pleating, and were characterized by immediate and significant cellular and humoral inflammatory responses. Porcine dermal-based grafts demonstrated significant graft pleating, minimal integration, and an absence of cellular repopulation and vascularization. However, a significant cellular immune response surrounded the grafts, coincident with poor initial wound healing strengths.
In vivo
observations for the three porcine-derived mesh products correlated with individual
in vitro
profiles, indicating an absence of characteristic biochemical markers and structural integrity. This correlation suggests that
in vivo
results observed for these mesh products are a direct consequence of specific manufacturing processes that yield modified collagen matrices. The resulting loss of biological and structural integrity elicits a foreign body response while hindering normal healing and tissue integration.</description><subject>Abdomen</subject><subject>Abdominal surgery</subject><subject>Abdominal Wall - pathology</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antibody Formation - immunology</subject><subject>Biocompatible Materials - metabolism</subject><subject>Biology</subject><subject>Biomechanical Phenomena</subject><subject>Biomedical materials</subject><subject>Disease Models, Animal</subject><subject>Hernia</subject><subject>Implants, Experimental</subject><subject>Muscles</subject><subject>Physiological aspects</subject><subject>Postoperative Care</subject><subject>Primates</subject><subject>Primates - immunology</subject><subject>Prosthesis Implantation</subject><subject>Surgery</subject><subject>Sus scrofa - metabolism</subject><subject>Tissue engineering</subject><subject>Titrimetry</subject><subject>Wound Healing</subject><issn>1937-3341</issn><issn>1937-335X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNklFr1TAUx4s43Jx-AF8kIvjW7qRpm_TxOqcbbDhE0beQpqcjI026JFfYtzflXhRF2AghyeH3_3POySmKVxQqCqI_SeiqhKqqAXgFjPInxRHtGS8Za388_X1v6GHxPMZbgA46zp8Vh1R0LYe6PSrMuY-JfMG4eBeRJE8u5sUql3Ak1z5o47D8gMH8zO_3xlt_YzS5UimHlI3EOKLIdTBzjpArP6IlfiKbYfSzccqS78ra7L4oE14UB1OW4Mv9eVx8-3j29fS8vPz86eJ0c1nqlvFUDkLrdmqUHjiMnaKDrhV2jFEGNVViautaaJzoqKkG1DWOANMAjUBkahCcHRfvdr5L8HdbjEnOJmq0uSj02yi7XtCug-ZBkPa5SY2ADL75B7z125DLi1L0NWu7fmXe7pgbZVEaN_kUlF4N5SYbQU67bjNV_YfKa8TZaO9wMjn-l4DuBDr4GANOclmbHe4lBbnOgMwzkLeS6wzIdQay5vU-3e0w4_hHsf_0DPAdsIaVc9bggCE9wvoXownABw</recordid><startdate>20081201</startdate><enddate>20081201</enddate><creator>Sandor, Maryellen</creator><creator>Xu, Hui</creator><creator>Connor, Jerome</creator><creator>Lombardi, Jared</creator><creator>Harper, John R.</creator><creator>Silverman, Ronald P.</creator><creator>McQuillan, David J.</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20081201</creationdate><title>Host Response to Implanted Porcine-Derived Biologic Materials in a Primate Model of Abdominal Wall Repair</title><author>Sandor, Maryellen ; Xu, Hui ; Connor, Jerome ; Lombardi, Jared ; Harper, John R. ; Silverman, Ronald P. ; McQuillan, David J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c537t-b8cc5f4acb70d6a1bc2ae63313021a8f5228cef1dc1c0ec2ed00fb048ee3ab873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Abdomen</topic><topic>Abdominal surgery</topic><topic>Abdominal Wall - pathology</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Antibody Formation - immunology</topic><topic>Biocompatible Materials - metabolism</topic><topic>Biology</topic><topic>Biomechanical Phenomena</topic><topic>Biomedical materials</topic><topic>Disease Models, Animal</topic><topic>Hernia</topic><topic>Implants, Experimental</topic><topic>Muscles</topic><topic>Physiological aspects</topic><topic>Postoperative Care</topic><topic>Primates</topic><topic>Primates - immunology</topic><topic>Prosthesis Implantation</topic><topic>Surgery</topic><topic>Sus scrofa - metabolism</topic><topic>Tissue engineering</topic><topic>Titrimetry</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sandor, Maryellen</creatorcontrib><creatorcontrib>Xu, Hui</creatorcontrib><creatorcontrib>Connor, Jerome</creatorcontrib><creatorcontrib>Lombardi, Jared</creatorcontrib><creatorcontrib>Harper, John R.</creatorcontrib><creatorcontrib>Silverman, Ronald P.</creatorcontrib><creatorcontrib>McQuillan, David J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Tissue engineering. Part A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sandor, Maryellen</au><au>Xu, Hui</au><au>Connor, Jerome</au><au>Lombardi, Jared</au><au>Harper, John R.</au><au>Silverman, Ronald P.</au><au>McQuillan, David J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Host Response to Implanted Porcine-Derived Biologic Materials in a Primate Model of Abdominal Wall Repair</atitle><jtitle>Tissue engineering. Part A</jtitle><addtitle>Tissue Eng Part A</addtitle><date>2008-12-01</date><risdate>2008</risdate><volume>14</volume><issue>12</issue><spage>221</spage><epage>2031</epage><pages>221-2031</pages><issn>1937-3341</issn><eissn>1937-335X</eissn><abstract>Three commercially available porcine-derived biologic meshes were implanted in an Old World primate abdominal wall resection repair model to compare biological outcome as a predictor of clinical efficacy. Tissues were explanted over a 6-month period and evaluated for gross pathology, wound healing strength, mesenchymal cellular repopulation, vascularity, and immune response.
In vivo
functional outcomes were correlated with
in vitro
profile for each material. Small intestinal submucosa-based implants demonstrated scar tissue formation and contraction, coincident with mesh pleating, and were characterized by immediate and significant cellular and humoral inflammatory responses. Porcine dermal-based grafts demonstrated significant graft pleating, minimal integration, and an absence of cellular repopulation and vascularization. However, a significant cellular immune response surrounded the grafts, coincident with poor initial wound healing strengths.
In vivo
observations for the three porcine-derived mesh products correlated with individual
in vitro
profiles, indicating an absence of characteristic biochemical markers and structural integrity. This correlation suggests that
in vivo
results observed for these mesh products are a direct consequence of specific manufacturing processes that yield modified collagen matrices. The resulting loss of biological and structural integrity elicits a foreign body response while hindering normal healing and tissue integration.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>18657025</pmid><doi>10.1089/ten.tea.2007.0317</doi><tpages>1811</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1937-3341 |
| ispartof | Tissue engineering. Part A, 2008-12, Vol.14 (12), p.221-2031 |
| issn | 1937-3341 1937-335X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69816604 |
| source | Mary Ann Liebert Online Subscription; MEDLINE; Alma/SFX Local Collection |
| subjects | Abdomen Abdominal surgery Abdominal Wall - pathology Animals Antibodies Antibody Formation - immunology Biocompatible Materials - metabolism Biology Biomechanical Phenomena Biomedical materials Disease Models, Animal Hernia Implants, Experimental Muscles Physiological aspects Postoperative Care Primates Primates - immunology Prosthesis Implantation Surgery Sus scrofa - metabolism Tissue engineering Titrimetry Wound Healing |
| title | Host Response to Implanted Porcine-Derived Biologic Materials in a Primate Model of Abdominal Wall Repair |
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