Novel DNA ligase with broad nucleotide cofactor specificity from the hyperthermophilic crenarchaeon Sulfophobococcus zilligii: influence of ancestral DNA ligase on cofactor utilization

Summary DNA ligases are divided into two groups according to their cofactor requirement to form ligase‐adenylate, ATP‐dependent DNA ligases and NAD+‐dependent DNA ligases. The conventional view that archaeal DNA ligases only utilize ATP has recently been disputed with discoveries of dual‐specificity...

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Veröffentlicht in:	Environmental microbiology 2008-12, Vol.10 (12), p.3212-3224
Hauptverfasser:	Sun, Younguk, Seo, Moo Seok, Kim, Jae Hyun, Kim, Yun Jae, Kim, Gun A, Lee, Jong Il, Lee, Jung-Hyun, Kwon, Suk-Tae
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - metabolism Adenosine Triphosphate - metabolism Amino Acid Sequence Coenzymes - pharmacology Desulfurococcaceae - enzymology Desulfurococcaceae - genetics Desulfurococcaceae - metabolism Desulfurococcales DNA - metabolism DNA Breaks, Single-Stranded DNA Ligases - genetics DNA Ligases - metabolism DNA, Archaeal - chemistry DNA, Archaeal - genetics Evolution, Molecular Guanosine Triphosphate - metabolism Molecular Sequence Data Nucleotides - pharmacology Sequence Alignment Sequence Analysis, DNA Sulfophobococcus zilligii Thermococcales
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