Effect of Cibenzoline and Atenolol Administration on Dynamic Left Ventricular Obstruction Due to Sigmoid-Shaped Septum
Obstruction of the left ventricular outflow tract (LVOT) is usually complicated by hypertrophic cardiomyopathy or left ventricular hypertrophy. It occurs rarely in cases of sigmoid-shaped septum (SS), which are considered as a normal part of the aging process. The 2 cases of SS with obstruction of t...
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| Veröffentlicht in: | Circulation Journal 2008, Vol.72(12), pp.2087-2091 |
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| container_title | Circulation Journal |
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| creator | Ozaki, Kazuyuki Sakuma, Ikki Mitsuma, Koko Suzuki, Tomoyasu Tsuchida, Keiichi Takahashi, Kazuyoshi Miida, Tsutomu Oda, Hirotaka |
| description | Obstruction of the left ventricular outflow tract (LVOT) is usually complicated by hypertrophic cardiomyopathy or left ventricular hypertrophy. It occurs rarely in cases of sigmoid-shaped septum (SS), which are considered as a normal part of the aging process. The 2 cases of SS with obstruction of the LVOT were observed. Their complaints were dyspnea on effort and exercise increased the left ventricular pressure gradient. In both cases, atenolol administration decreased rest pressure gradient. Moreover, additional cibenzoline administration decreased the pressure gradient caused by exercise. It is emphasized that dual therapy with cibenzoline and atenolol is effective in resolving the obstruction of the LVOT caused by SS. (Circ J 2008; 72: 2087 - 2091) |
| doi_str_mv | 10.1253/circj.CJ-07-0897 |
| format | Article |
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It occurs rarely in cases of sigmoid-shaped septum (SS), which are considered as a normal part of the aging process. The 2 cases of SS with obstruction of the LVOT were observed. Their complaints were dyspnea on effort and exercise increased the left ventricular pressure gradient. In both cases, atenolol administration decreased rest pressure gradient. Moreover, additional cibenzoline administration decreased the pressure gradient caused by exercise. It is emphasized that dual therapy with cibenzoline and atenolol is effective in resolving the obstruction of the LVOT caused by SS. 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It occurs rarely in cases of sigmoid-shaped septum (SS), which are considered as a normal part of the aging process. The 2 cases of SS with obstruction of the LVOT were observed. Their complaints were dyspnea on effort and exercise increased the left ventricular pressure gradient. In both cases, atenolol administration decreased rest pressure gradient. Moreover, additional cibenzoline administration decreased the pressure gradient caused by exercise. It is emphasized that dual therapy with cibenzoline and atenolol is effective in resolving the obstruction of the LVOT caused by SS. (Circ J 2008; 72: 2087 - 2091)</description><subject>Adrenergic beta-Antagonists - therapeutic use</subject><subject>Aged</subject><subject>Aging - pathology</subject><subject>Anti-Arrhythmia Agents - therapeutic use</subject><subject>Atenolol - therapeutic use</subject><subject>Blood Pressure - drug effects</subject><subject>Cibenzoline</subject><subject>Drug Therapy, Combination</subject><subject>Dyspnea - drug therapy</subject><subject>Dyspnea - etiology</subject><subject>Echocardiography, Doppler</subject><subject>Electrocardiography</subject><subject>Exercise Test</subject><subject>Exercise Tolerance - drug effects</subject><subject>Heart Septum - pathology</subject><subject>Humans</subject><subject>Imidazoles - therapeutic use</subject><subject>Left ventricular outflow obstruction</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pressure gradient</subject><subject>Sigmoid-shaped septum</subject><subject>Treatment Outcome</subject><subject>Ventricular Function, Left - drug effects</subject><subject>Ventricular Outflow Obstruction - drug therapy</subject><subject>Ventricular Outflow Obstruction - etiology</subject><subject>Ventricular Outflow Obstruction - pathology</subject><subject>Ventricular Outflow Obstruction - physiopathology</subject><subject>Ventricular Pressure - drug effects</subject><issn>1346-9843</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkD1v2zAQhomiRZO43TsFnLoppURSIkdDSZMGBjy47UpQ1DGhIZEOSQVIfn3lD9TA4e6G532GF6FvJbkpK05_GBfN9qZ9LEhTECGbD-iypKwpmKjIx8NfF1IweoGuUtoSUknC5Wd0UQrBWV02l-j1zlowGQeLW9eBfw-D84C17_Eygw9DGPCyH513KUedXfB4nts3r0dn8Apsxn_B5-jMNOiI192MTebA3U6Ac8Ab9zQG1xebZ72DHm9gl6fxC_pk9ZDg6-ku0J-fd7_bh2K1vv_VLleF4ZLlwkpJLSNU614wIwhjpOmrmkqwpLMCSkq5NlzUIDQRnbEdt5wSTmXFNUBHF-j70buL4WWClNXokoFh0B7ClFQtRckplzNIjqCJIaUIVu2iG3V8UyVR-67VoWvVPirSqH3Xc-T65J66Efpz4FTuDNwfgW3K-gn-AzpmZwY4GZtq9u_3WX0mnnVU4Ok_esaW7Q</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Ozaki, Kazuyuki</creator><creator>Sakuma, Ikki</creator><creator>Mitsuma, Koko</creator><creator>Suzuki, Tomoyasu</creator><creator>Tsuchida, Keiichi</creator><creator>Takahashi, Kazuyoshi</creator><creator>Miida, Tsutomu</creator><creator>Oda, Hirotaka</creator><general>The Japanese Circulation Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2008</creationdate><title>Effect of Cibenzoline and Atenolol Administration on Dynamic Left Ventricular Obstruction Due to Sigmoid-Shaped Septum</title><author>Ozaki, Kazuyuki ; Sakuma, Ikki ; Mitsuma, Koko ; Suzuki, Tomoyasu ; Tsuchida, Keiichi ; Takahashi, Kazuyoshi ; Miida, Tsutomu ; Oda, Hirotaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c594t-f993f403aad84c804407d2639ef0bf8e1335ac586e8a08bcfb5f53053925aeeb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adrenergic beta-Antagonists - therapeutic use</topic><topic>Aged</topic><topic>Aging - pathology</topic><topic>Anti-Arrhythmia Agents - therapeutic use</topic><topic>Atenolol - therapeutic use</topic><topic>Blood Pressure - drug effects</topic><topic>Cibenzoline</topic><topic>Drug Therapy, Combination</topic><topic>Dyspnea - drug therapy</topic><topic>Dyspnea - etiology</topic><topic>Echocardiography, Doppler</topic><topic>Electrocardiography</topic><topic>Exercise Test</topic><topic>Exercise Tolerance - drug effects</topic><topic>Heart Septum - pathology</topic><topic>Humans</topic><topic>Imidazoles - therapeutic use</topic><topic>Left ventricular outflow obstruction</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pressure gradient</topic><topic>Sigmoid-shaped septum</topic><topic>Treatment Outcome</topic><topic>Ventricular Function, Left - drug effects</topic><topic>Ventricular Outflow Obstruction - drug therapy</topic><topic>Ventricular Outflow Obstruction - etiology</topic><topic>Ventricular Outflow Obstruction - pathology</topic><topic>Ventricular Outflow Obstruction - physiopathology</topic><topic>Ventricular Pressure - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ozaki, Kazuyuki</creatorcontrib><creatorcontrib>Sakuma, Ikki</creatorcontrib><creatorcontrib>Mitsuma, Koko</creatorcontrib><creatorcontrib>Suzuki, Tomoyasu</creatorcontrib><creatorcontrib>Tsuchida, Keiichi</creatorcontrib><creatorcontrib>Takahashi, Kazuyoshi</creatorcontrib><creatorcontrib>Miida, Tsutomu</creatorcontrib><creatorcontrib>Oda, Hirotaka</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ozaki, Kazuyuki</au><au>Sakuma, Ikki</au><au>Mitsuma, Koko</au><au>Suzuki, Tomoyasu</au><au>Tsuchida, Keiichi</au><au>Takahashi, Kazuyoshi</au><au>Miida, Tsutomu</au><au>Oda, Hirotaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Cibenzoline and Atenolol Administration on Dynamic Left Ventricular Obstruction Due to Sigmoid-Shaped Septum</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2008</date><risdate>2008</risdate><volume>72</volume><issue>12</issue><spage>2087</spage><epage>2091</epage><pages>2087-2091</pages><issn>1346-9843</issn><eissn>1347-4820</eissn><abstract>Obstruction of the left ventricular outflow tract (LVOT) is usually complicated by hypertrophic cardiomyopathy or left ventricular hypertrophy. It occurs rarely in cases of sigmoid-shaped septum (SS), which are considered as a normal part of the aging process. The 2 cases of SS with obstruction of the LVOT were observed. Their complaints were dyspnea on effort and exercise increased the left ventricular pressure gradient. In both cases, atenolol administration decreased rest pressure gradient. Moreover, additional cibenzoline administration decreased the pressure gradient caused by exercise. It is emphasized that dual therapy with cibenzoline and atenolol is effective in resolving the obstruction of the LVOT caused by SS. (Circ J 2008; 72: 2087 - 2091)</abstract><cop>Japan</cop><pub>The Japanese Circulation Society</pub><pmid>18854617</pmid><doi>10.1253/circj.CJ-07-0897</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Adrenergic beta-Antagonists - therapeutic use Aged Aging - pathology Anti-Arrhythmia Agents - therapeutic use Atenolol - therapeutic use Blood Pressure - drug effects Cibenzoline Drug Therapy, Combination Dyspnea - drug therapy Dyspnea - etiology Echocardiography, Doppler Electrocardiography Exercise Test Exercise Tolerance - drug effects Heart Septum - pathology Humans Imidazoles - therapeutic use Left ventricular outflow obstruction Male Middle Aged Pressure gradient Sigmoid-shaped septum Treatment Outcome Ventricular Function, Left - drug effects Ventricular Outflow Obstruction - drug therapy Ventricular Outflow Obstruction - etiology Ventricular Outflow Obstruction - pathology Ventricular Outflow Obstruction - physiopathology Ventricular Pressure - drug effects |
| title | Effect of Cibenzoline and Atenolol Administration on Dynamic Left Ventricular Obstruction Due to Sigmoid-Shaped Septum |
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