Cerebrovascular Hemodynamics and Ischemic Tolerance: Lipopolysaccharide-Induced Resistance to Focal Cerebral Ischemia is not Due to Changes in Severity of the Initial Ischemic Insult, but is Associated with Preservation of Microvascular Perfusion

Lipopolysaccharide (LPS), administered 72 hours before middle cerebral artery (MCA) occlusion, confers significant protection against ischemic injury. For example, in the present study, LPS (0.9 mg/kg intravenously) induced a 31% reduction in infarct volume (compared with saline control) assessed 24...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 1999-06, Vol.19 (6), p.616-623
Hauptverfasser:	Dawson, Deborah A., Furuya, Kazuhide, Gotoh, Jun, Nakao, Yasuaki, Hallenbeck, John M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Gas Analysis Blood Pressure - drug effects Brain Ischemia - physiopathology Cerebral Arteries - physiology Cerebrovascular Circulation - drug effects Endotoxins - pharmacology Escherichia coli - metabolism Lipopolysaccharides - pharmacology Male Medical sciences Microcirculation - drug effects Neurology Nitric Oxide - blood Rats Rats, Inbred SHR Vascular diseases and vascular malformations of the nervous system
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