The pressure of finding human hypertension genes: new tools, old dilemmas
Researchers in hypertension genetics feel like they are left behind again. It always seems that the ‘other’ complex diseases are ahead in the race. Evolving new technologies in the form of genome-wide arrays and ‘omics’ technologies mean that investigators can now potentially identify many novel dis...
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| Veröffentlicht in: | Journal of human hypertension 2008-12, Vol.22 (12), p.821-828 |
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| container_title | Journal of human hypertension |
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| creator | Charchar, F J Zimmerli, L U Tomaszewski, M |
| description | Researchers in hypertension genetics feel like they are left behind again. It always seems that the ‘other’ complex diseases are ahead in the race. Evolving new technologies in the form of genome-wide arrays and ‘omics’ technologies mean that investigators can now potentially identify many novel disease factors in one large-scale experiment. Hypertension research now faces the challenge of where to go next after the first genome-wide association experiments failed to provide robust candidates. In this review, we contemplate the old dilemma of whether such genes may ever be found; however, we believe advancing technologies and plummeting costs of large-scale experiments will contribute to the identification of novel molecules that underlie essential hypertension. |
| doi_str_mv | 10.1038/jhh.2008.67 |
| format | Article |
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It always seems that the ‘other’ complex diseases are ahead in the race. Evolving new technologies in the form of genome-wide arrays and ‘omics’ technologies mean that investigators can now potentially identify many novel disease factors in one large-scale experiment. Hypertension research now faces the challenge of where to go next after the first genome-wide association experiments failed to provide robust candidates. In this review, we contemplate the old dilemma of whether such genes may ever be found; however, we believe advancing technologies and plummeting costs of large-scale experiments will contribute to the identification of novel molecules that underlie essential hypertension.</description><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular diseases</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Complications and side effects</subject><subject>Epidemiology</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic Predisposition to Disease</subject><subject>Genome, Human</subject><subject>Genomes</subject><subject>Genomics - methods</subject><subject>Genomics - trends</subject><subject>Health Administration</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - genetics</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Public Health</subject><subject>review</subject><subject>Risk factors</subject><issn>0950-9240</issn><issn>1476-5527</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1ks1vEzEQxS0EoiFw4o4sEL3QBH-s7TW3quKjUiUuuVuOd5zdaNcO9q6q_vd4lYhQVOSDD_Obefabh9BbStaU8Przvm3XjJB6LdUztKCVkishmHqOFkQLstKsIhfoVc57QuZi_RJd0FpyXrF6gW43LeBDgpynBDh67LvQdGGH22mwAbcPB0gjhNzFgHcQIH_BAe7xGGOfr3DsG9x0PQyDza_RC2_7DG9O9xJtvn3d3PxY3f38fntzfbdygqhx1RDiG8c1Z55UWjDtgBNNlLOWEd5YopqtrrgSzHtWscpyX3OhwSq_pSD5El0exx5S_DVBHs3QZQd9bwPEKRupa0qEmsEP_4D7OKVQnmaYrArCK0kL9f6_FNVaCq6q86id7cF0wccxWTfrmmuqSS2olrPg-gmqnAaGzsUAvjj1uOHyr4YWbD-2OfbTWMzOj8FPR9ClmHMCbw6pG2x6MJSYOQOmZMDMGTBSFfrd6UvTdoDmzJ6WXoCPJ8BmZ3ufbHBd_sOxIstp2dASXR25XEphB-nszVO6vwFyZsOh</recordid><startdate>20081201</startdate><enddate>20081201</enddate><creator>Charchar, F J</creator><creator>Zimmerli, L U</creator><creator>Tomaszewski, M</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20081201</creationdate><title>The pressure of finding human hypertension genes: new tools, old dilemmas</title><author>Charchar, F J ; Zimmerli, L U ; Tomaszewski, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-d00fdc3932f049529ce30907caa203da07db943752ff2424a3f8359ea7fb1e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular diseases</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Complications and side effects</topic><topic>Epidemiology</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic Predisposition to Disease</topic><topic>Genome, Human</topic><topic>Genomes</topic><topic>Genomics - methods</topic><topic>Genomics - trends</topic><topic>Health Administration</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - genetics</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Public Health</topic><topic>review</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Charchar, F J</creatorcontrib><creatorcontrib>Zimmerli, L U</creatorcontrib><creatorcontrib>Tomaszewski, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of human hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Charchar, F J</au><au>Zimmerli, L U</au><au>Tomaszewski, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The pressure of finding human hypertension genes: new tools, old dilemmas</atitle><jtitle>Journal of human hypertension</jtitle><stitle>J Hum Hypertens</stitle><addtitle>J Hum Hypertens</addtitle><date>2008-12-01</date><risdate>2008</risdate><volume>22</volume><issue>12</issue><spage>821</spage><epage>828</epage><pages>821-828</pages><issn>0950-9240</issn><eissn>1476-5527</eissn><abstract>Researchers in hypertension genetics feel like they are left behind again. 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| subjects | Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular diseases Clinical manifestations. Epidemiology. Investigative techniques. Etiology Complications and side effects Epidemiology Genes Genetic aspects Genetic Predisposition to Disease Genome, Human Genomes Genomics - methods Genomics - trends Health Administration Humans Hypertension Hypertension - genetics Medical sciences Medicine Medicine & Public Health Public Health review Risk factors |
| title | The pressure of finding human hypertension genes: new tools, old dilemmas |
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