Composite signalling from Serrate and Delta establishes leg segments in Drosophila through Notch
The receptor protein NOTCH and its ligands SERRATE and DELTA are involved in many developmental processes in invertebrates and vertebrates alike. Here we show that the expression of the Serrate and Delta genes patterns the segments of the leg in Drosophila by a combination of their signalling activi...
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| Veröffentlicht in: | Development (Cambridge) 1999-07, Vol.126 (13), p.2993-3003 |
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| container_title | Development (Cambridge) |
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| creator | Bishop, S A Klein, T Arias, A M Couso, J P |
| description | The receptor protein NOTCH and its ligands SERRATE and DELTA are involved in many developmental processes in invertebrates and vertebrates alike. Here we show that the expression of the Serrate and Delta genes patterns the segments of the leg in Drosophila by a combination of their signalling activities. Coincident stripes of Serrate and Delta expressing cells activate Enhancer of split expression in adjacent cells through Notch signalling. These cells form a patterning boundary from which a putative secondary signal leads to the development of leg joints. Elsewhere in the tarsal segments, signalling by DELTA and NOTCH is necessary for the development of non-joint parts of the leg. We propose that these two effects result from different thresholds of NOTCH activation, which are translated into different downstream gene expression effects. We propose a general mechanism for creation of boundaries by Notch signalling. |
| doi_str_mv | 10.1242/dev.126.13.2993 |
| format | Article |
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Here we show that the expression of the Serrate and Delta genes patterns the segments of the leg in Drosophila by a combination of their signalling activities. Coincident stripes of Serrate and Delta expressing cells activate Enhancer of split expression in adjacent cells through Notch signalling. These cells form a patterning boundary from which a putative secondary signal leads to the development of leg joints. Elsewhere in the tarsal segments, signalling by DELTA and NOTCH is necessary for the development of non-joint parts of the leg. We propose that these two effects result from different thresholds of NOTCH activation, which are translated into different downstream gene expression effects. We propose a general mechanism for creation of boundaries by Notch signalling.</description><subject>Adaptor Proteins, Signal Transducing</subject><subject>Animals</subject><subject>Calcium-Binding Proteins</subject><subject>Dishevelled Proteins</subject><subject>Drosophila</subject><subject>Drosophila - embryology</subject><subject>Drosophila - genetics</subject><subject>Drosophila Proteins</subject><subject>Extremities - embryology</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genes, Reporter</subject><subject>Immunohistochemistry</subject><subject>Insect Proteins - genetics</subject><subject>Intercellular Signaling Peptides and Proteins</subject><subject>Intracellular Signaling Peptides and Proteins</subject><subject>Jagged-1 Protein</subject><subject>Ligands</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - metabolism</subject><subject>Microscopy, Fluorescence</subject><subject>Mutation</subject><subject>N-Acetylglucosaminyltransferases</subject><subject>Phosphoproteins</subject><subject>Receptors, Notch</subject><subject>Serrate-Jagged Proteins</subject><subject>Signal Transduction - genetics</subject><issn>0950-1991</issn><issn>1477-9129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD2P1DAQhi0E4paDmg65osuev2LHJdo7PqQTFEBtZpNxYuTEwc6C-Pd4tVdARTWj0TOPZl5CXnK250KJmwF_1kbvudwLa-UjsuPKmMZyYR-THbMta7i1_Io8K-U7Y0xqY56SK85ka6wSO_LtkOY1lbAhLWFcIMawjNTnNNPPmDPUOSwDvcW4AcWywTGGMmGhEUdacJxx2QoNC73NqaR1ChHoNuV0Gif6MW399Jw88RALvnio1-Tr27svh_fN_ad3Hw5v7pteark1rR_AtBp6wK4zMHCGx873CN4YLloFyvgWdWs7GKTWoLQwRjLFtPetRS2vyeuLd83px6le6uZQeowRFkyn4rTtOBNM_RfkRgqrtKngzQXs62slo3drDjPk344zd07f1fRrox2X7px-3Xj1oD4dZxz-4i9xV2B_AaYwTr9CRncMKaYxlK2cbRjT-o_xD_vMkeU</recordid><startdate>19990701</startdate><enddate>19990701</enddate><creator>Bishop, S A</creator><creator>Klein, T</creator><creator>Arias, A M</creator><creator>Couso, J P</creator><general>The Company of Biologists Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19990701</creationdate><title>Composite signalling from Serrate and Delta establishes leg segments in Drosophila through Notch</title><author>Bishop, S A ; Klein, T ; Arias, A M ; Couso, J P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c363t-5fda756acae887ad10eb8fceaf771254a47f5e6598ad366a4627730406ff59e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adaptor Proteins, Signal Transducing</topic><topic>Animals</topic><topic>Calcium-Binding Proteins</topic><topic>Dishevelled Proteins</topic><topic>Drosophila</topic><topic>Drosophila - embryology</topic><topic>Drosophila - genetics</topic><topic>Drosophila Proteins</topic><topic>Extremities - embryology</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Genes, Reporter</topic><topic>Immunohistochemistry</topic><topic>Insect Proteins - genetics</topic><topic>Intercellular Signaling Peptides and Proteins</topic><topic>Intracellular Signaling Peptides and Proteins</topic><topic>Jagged-1 Protein</topic><topic>Ligands</topic><topic>Membrane Proteins - genetics</topic><topic>Membrane Proteins - metabolism</topic><topic>Microscopy, Fluorescence</topic><topic>Mutation</topic><topic>N-Acetylglucosaminyltransferases</topic><topic>Phosphoproteins</topic><topic>Receptors, Notch</topic><topic>Serrate-Jagged Proteins</topic><topic>Signal Transduction - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bishop, S A</creatorcontrib><creatorcontrib>Klein, T</creatorcontrib><creatorcontrib>Arias, A M</creatorcontrib><creatorcontrib>Couso, J P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Development (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bishop, S A</au><au>Klein, T</au><au>Arias, A M</au><au>Couso, J P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Composite signalling from Serrate and Delta establishes leg segments in Drosophila through Notch</atitle><jtitle>Development (Cambridge)</jtitle><addtitle>Development</addtitle><date>1999-07-01</date><risdate>1999</risdate><volume>126</volume><issue>13</issue><spage>2993</spage><epage>3003</epage><pages>2993-3003</pages><issn>0950-1991</issn><eissn>1477-9129</eissn><abstract>The receptor protein NOTCH and its ligands SERRATE and DELTA are involved in many developmental processes in invertebrates and vertebrates alike. Here we show that the expression of the Serrate and Delta genes patterns the segments of the leg in Drosophila by a combination of their signalling activities. Coincident stripes of Serrate and Delta expressing cells activate Enhancer of split expression in adjacent cells through Notch signalling. These cells form a patterning boundary from which a putative secondary signal leads to the development of leg joints. Elsewhere in the tarsal segments, signalling by DELTA and NOTCH is necessary for the development of non-joint parts of the leg. We propose that these two effects result from different thresholds of NOTCH activation, which are translated into different downstream gene expression effects. We propose a general mechanism for creation of boundaries by Notch signalling.</abstract><cop>England</cop><pub>The Company of Biologists Limited</pub><pmid>10357942</pmid><doi>10.1242/dev.126.13.2993</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-1991 |
| ispartof | Development (Cambridge), 1999-07, Vol.126 (13), p.2993-3003 |
| issn | 0950-1991 1477-9129 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69810204 |
| source | MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library; Company of Biologists |
| subjects | Adaptor Proteins, Signal Transducing Animals Calcium-Binding Proteins Dishevelled Proteins Drosophila Drosophila - embryology Drosophila - genetics Drosophila Proteins Extremities - embryology Gene Expression Regulation, Developmental Genes, Reporter Immunohistochemistry Insect Proteins - genetics Intercellular Signaling Peptides and Proteins Intracellular Signaling Peptides and Proteins Jagged-1 Protein Ligands Membrane Proteins - genetics Membrane Proteins - metabolism Microscopy, Fluorescence Mutation N-Acetylglucosaminyltransferases Phosphoproteins Receptors, Notch Serrate-Jagged Proteins Signal Transduction - genetics |
| title | Composite signalling from Serrate and Delta establishes leg segments in Drosophila through Notch |
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