A role for Sonic hedgehog in axon-to-astrocyte signalling in the rodent optic nerve

Retinal ganglion cell (RGC) axons have been shown to stimulate the proliferation of astrocytes in the developing rodent optic nerve, but the signals that mediate this effect have not been identified. The following findings suggest that Sonic hedgehog (Shh) is one of the signals. (1) RGCs express bot...

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Veröffentlicht in:	Development (Cambridge) 1999-07, Vol.126 (13), p.2901-2909
Hauptverfasser:	Wallace, V A, Raff, M C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - pharmacology Astrocytes - metabolism Axons - metabolism Cell Division DNA-Binding Proteins - metabolism Gene Expression Regulation, Developmental Glial Fibrillary Acidic Protein - genetics Hedgehog Proteins In Situ Hybridization Intracellular Signaling Peptides and Proteins Membrane Proteins - genetics Mice Mice, Inbred Strains Optic Nerve - embryology Patched Receptors Patched-1 Receptor PAX2 Transcription Factor Proteins - genetics Proteins - immunology Receptors, Cell Surface Retinal Ganglion Cells - metabolism RNA, Messenger - metabolism Signal Transduction - genetics Trans-Activators Transcription Factors - metabolism
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