Antiphospholipid antibodies in infertile couples with two consecutive miscarriages after in-vitro fertilization and embryo transfer
Of 682 women who had undergone in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) with embryo transfer, 84 were successful on two occasions, with 16 of these resulting in miscarriage before 20 completed weeks. Antiphospholipid antibodies (APA) were estimated by enzyme-linked imm...
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| Veröffentlicht in: | Human reproduction (Oxford) 1999-06, Vol.14 (6), p.1483-1486 |
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| creator | Egbase, P.E. Al Sharhan, M. Diejomaoh, M. Grudzinskas, J.G. |
| description | Of 682 women who had undergone in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) with embryo transfer, 84 were successful on two occasions, with 16 of these resulting in miscarriage before 20 completed weeks. Antiphospholipid antibodies (APA) were estimated by enzyme-linked immunosorbent assay in these women (group 1) and compared to two control groups: 42 fertile women with three or more miscarriages (group 2) and 60 women with primary infertility undergoing IVF or ICSI (group 3). An apparently higher prevalence of seropositivity was seen in group 1 women (25%) compared to the group 3 women (6.6%) and it was similar to that seen in group 2 women (21.4%). Therefore the recommendation that women with two consecutive miscarriages after IVF or ICSI should have APA estimations performed routinely may be justified. |
| doi_str_mv | 10.1093/humrep/14.6.1483 |
| format | Article |
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Antiphospholipid antibodies (APA) were estimated by enzyme-linked immunosorbent assay in these women (group 1) and compared to two control groups: 42 fertile women with three or more miscarriages (group 2) and 60 women with primary infertility undergoing IVF or ICSI (group 3). An apparently higher prevalence of seropositivity was seen in group 1 women (25%) compared to the group 3 women (6.6%) and it was similar to that seen in group 2 women (21.4%). Therefore the recommendation that women with two consecutive miscarriages after IVF or ICSI should have APA estimations performed routinely may be justified.</description><identifier>ISSN: 0268-1161</identifier><identifier>EISSN: 1460-2350</identifier><identifier>DOI: 10.1093/humrep/14.6.1483</identifier><identifier>PMID: 10357964</identifier><identifier>CODEN: HUREEE</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Abortion, Spontaneous - immunology ; Adult ; Antibodies, Antiphospholipid - blood ; antiphospholipid antibodies ; Biological and medical sciences ; Diseases of mother, fetus and pregnancy ; Embryo Transfer ; Female ; Fertilization in Vitro - methods ; Gynecology. Andrology. Obstetrics ; Humans ; Infertility - immunology ; Infertility - therapy ; IVF ; Male ; Medical sciences ; Microinjections ; Pregnancy ; Pregnancy. Fetus. Placenta ; Recurrence ; two consecutive miscarriages</subject><ispartof>Human reproduction (Oxford), 1999-06, Vol.14 (6), p.1483-1486</ispartof><rights>European Society of Human Reproduction and Embryology 1999</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-5c017965f742979a4560567e3f5b8fb7c6f2e7a0d07ae29ce133799a03bb7b83</citedby><cites>FETCH-LOGICAL-c440t-5c017965f742979a4560567e3f5b8fb7c6f2e7a0d07ae29ce133799a03bb7b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1867951$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10357964$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Egbase, P.E.</creatorcontrib><creatorcontrib>Al Sharhan, M.</creatorcontrib><creatorcontrib>Diejomaoh, M.</creatorcontrib><creatorcontrib>Grudzinskas, J.G.</creatorcontrib><title>Antiphospholipid antibodies in infertile couples with two consecutive miscarriages after in-vitro fertilization and embryo transfer</title><title>Human reproduction (Oxford)</title><addtitle>Hum. Reprod</addtitle><addtitle>Hum. Reprod</addtitle><description>Of 682 women who had undergone in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) with embryo transfer, 84 were successful on two occasions, with 16 of these resulting in miscarriage before 20 completed weeks. Antiphospholipid antibodies (APA) were estimated by enzyme-linked immunosorbent assay in these women (group 1) and compared to two control groups: 42 fertile women with three or more miscarriages (group 2) and 60 women with primary infertility undergoing IVF or ICSI (group 3). An apparently higher prevalence of seropositivity was seen in group 1 women (25%) compared to the group 3 women (6.6%) and it was similar to that seen in group 2 women (21.4%). Therefore the recommendation that women with two consecutive miscarriages after IVF or ICSI should have APA estimations performed routinely may be justified.</description><subject>Abortion, Spontaneous - immunology</subject><subject>Adult</subject><subject>Antibodies, Antiphospholipid - blood</subject><subject>antiphospholipid antibodies</subject><subject>Biological and medical sciences</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Embryo Transfer</subject><subject>Female</subject><subject>Fertilization in Vitro - methods</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Infertility - immunology</subject><subject>Infertility - therapy</subject><subject>IVF</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microinjections</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Recurrence</subject><subject>two consecutive miscarriages</subject><issn>0268-1161</issn><issn>1460-2350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM1rFTEUxYMo9lndu5JZiBuZ12TyNVmWh7VKQYSC0k3IZG580ZnJmGRa69Z_3DzmoS6FhFxufufk5iD0nOAtwYqe7ZcxwnxG2FZsCWvpA7QhTOC6oRw_RBvciLYmRJAT9CSlrxiXshWP0QnBlEsl2Ab9Op-yn_chlT342feVKY0u9B5S5aeyHMTsB6hsWOahNO983lf5LpTGlMAu2d9CNfpkTYzefCmEcRliUda3PsdQrQb-p8k-TMW-r2Ds4n2ocjRTKrdP0SNnhgTPjucpur54c727rK8-vH23O7-qLWM419xiUobmTrJGSWUYF5gLCdTxrnWdtMI1IA3usTTQKAuEUqmUwbTrZNfSU_RqtZ1j-L5AyvowNQyDmSAsSQvVYsUFLSBeQRtDShGcnqMfTbzXBOtD7nrNXROmhT7kXiQvjt5LN0L_j2ANugAvj4ApSQ2ufN369JdrhVScFOz1ipWw_-fVeqV9yvDjD2_iNy0klVxffr7Ru08f2fuLFusb-htgE62-</recordid><startdate>19990601</startdate><enddate>19990601</enddate><creator>Egbase, P.E.</creator><creator>Al Sharhan, M.</creator><creator>Diejomaoh, M.</creator><creator>Grudzinskas, J.G.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990601</creationdate><title>Antiphospholipid antibodies in infertile couples with two consecutive miscarriages after in-vitro fertilization and embryo transfer</title><author>Egbase, P.E. ; Al Sharhan, M. ; Diejomaoh, M. ; Grudzinskas, J.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-5c017965f742979a4560567e3f5b8fb7c6f2e7a0d07ae29ce133799a03bb7b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Abortion, Spontaneous - immunology</topic><topic>Adult</topic><topic>Antibodies, Antiphospholipid - blood</topic><topic>antiphospholipid antibodies</topic><topic>Biological and medical sciences</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Embryo Transfer</topic><topic>Female</topic><topic>Fertilization in Vitro - methods</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Infertility - immunology</topic><topic>Infertility - therapy</topic><topic>IVF</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microinjections</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Recurrence</topic><topic>two consecutive miscarriages</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Egbase, P.E.</creatorcontrib><creatorcontrib>Al Sharhan, M.</creatorcontrib><creatorcontrib>Diejomaoh, M.</creatorcontrib><creatorcontrib>Grudzinskas, J.G.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human reproduction (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Egbase, P.E.</au><au>Al Sharhan, M.</au><au>Diejomaoh, M.</au><au>Grudzinskas, J.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiphospholipid antibodies in infertile couples with two consecutive miscarriages after in-vitro fertilization and embryo transfer</atitle><jtitle>Human reproduction (Oxford)</jtitle><stitle>Hum. Reprod</stitle><addtitle>Hum. Reprod</addtitle><date>1999-06-01</date><risdate>1999</risdate><volume>14</volume><issue>6</issue><spage>1483</spage><epage>1486</epage><pages>1483-1486</pages><issn>0268-1161</issn><eissn>1460-2350</eissn><coden>HUREEE</coden><abstract>Of 682 women who had undergone in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) with embryo transfer, 84 were successful on two occasions, with 16 of these resulting in miscarriage before 20 completed weeks. Antiphospholipid antibodies (APA) were estimated by enzyme-linked immunosorbent assay in these women (group 1) and compared to two control groups: 42 fertile women with three or more miscarriages (group 2) and 60 women with primary infertility undergoing IVF or ICSI (group 3). An apparently higher prevalence of seropositivity was seen in group 1 women (25%) compared to the group 3 women (6.6%) and it was similar to that seen in group 2 women (21.4%). Therefore the recommendation that women with two consecutive miscarriages after IVF or ICSI should have APA estimations performed routinely may be justified.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>10357964</pmid><doi>10.1093/humrep/14.6.1483</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Human reproduction (Oxford), 1999-06, Vol.14 (6), p.1483-1486 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Abortion, Spontaneous - immunology Adult Antibodies, Antiphospholipid - blood antiphospholipid antibodies Biological and medical sciences Diseases of mother, fetus and pregnancy Embryo Transfer Female Fertilization in Vitro - methods Gynecology. Andrology. Obstetrics Humans Infertility - immunology Infertility - therapy IVF Male Medical sciences Microinjections Pregnancy Pregnancy. Fetus. Placenta Recurrence two consecutive miscarriages |
| title | Antiphospholipid antibodies in infertile couples with two consecutive miscarriages after in-vitro fertilization and embryo transfer |
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