Induction of apoptosis in HT-29 colon cancer cells by crude saponin from Platycodi Radix

This study examined the apoptotic effects of crude saponins acquired from the roots of Platycodon grandiflorum (SPR) in HT-29 human colon cancer cells. SPR decreased HT-29 cell proliferation in dose- and time-dependent manners by inducing apoptosis via DNA fragmentation and poly (ADP-ribose) polymer...

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Veröffentlicht in:	Food and chemical toxicology 2008-12, Vol.46 (12), p.3753-3758
Hauptverfasser:	Kim, Jae-Yong, Park, Kyoung-Wuk, Moon, Kwang-Deog, Lee, Mi-Kyung, Choi, Jina, Yee, Sung-Tae, Shim, Ki-Hwan, Seo, Kwon-Il
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Biological and medical sciences Caspase Inhibitors Caspases - metabolism Cell Proliferation - drug effects Colon cancer cells colorectal neoplasms Cytotoxicity cytotoxins DNA damage DNA fragmentation DNA Fragmentation - drug effects enzyme inhibitors Enzyme Inhibitors - pharmacology Gastroenterology. Liver. Pancreas. Abdomen HT29 Cells Humans indigenous species L-Lactate Dehydrogenase - metabolism Medical sciences Mitochondria - drug effects Oriental traditional medicine pathogenesis-related proteins plant extracts Platycodon - chemistry Platycodon grandiflorum roots Saponin saponins Saponins - isolation & purification Saponins - pharmacology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Toxicology Tumors
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