Increase in endotoxin-induced mucosal permeability is related to increased nitric oxide synthase activity using the Ussing chamber

OBJECTIVETo determine if nitric oxide production is associated with increased intestinal permeability after endotoxin challenge using the ex vivo Ussing chamber. SUBJECTSIleal mucosal membranes harvested from normal rats weighing 300 to 420 g. INTERVENTIONSEndotoxin (lipopolysaccharide), 1, 10, 100...

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Veröffentlicht in:	Critical care medicine 1999-05, Vol.27 (5), p.880-886
Hauptverfasser:	Mishima, Shiro, Xu, Dazhong, Deitch, Edwin A
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Bacterial Translocation - physiology Biological and medical sciences Cell Membrane Permeability - physiology Disease Models, Animal Emergency and intensive care: infection, septic shock Escherichia coli Ileum In Vitro Techniques Intensive care medicine Intestinal Mucosa - enzymology Intestinal Mucosa - microbiology Lipopolysaccharides - adverse effects Male Medical sciences Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - physiology omega-N-Methylarginine - pharmacology Rats Rats, Sprague-Dawley Time Factors
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