Candesartan and Insulin Reduce Renal Sympathetic Nerve Activity in Hypertensive Type 1 Diabetic Rats
The nonlinearity of cardiovascular regulation is higher in normal physiology, whereas several diseases are characterized by a reduction in this nonlinearity. Reduced nonlinearity of heart rate regulation is a robust risk factor for high mortality in patients with myocardial infarction. We investigat...
Gespeichert in:
| Veröffentlicht in: | Hypertension research 2008-10, Vol.31 (10), p.1941-1951 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1951 |
|---|---|
| container_issue | 10 |
| container_start_page | 1941 |
| container_title | Hypertension research |
| container_volume | 31 |
| creator | Takimoto, Chie Kumagai, Hiroo Osaka, Motohisa Sakata, Katsufumi Onami, Toshiko Kamayachi, Tadashi Iigaya, Kamon Hayashi, Koichi Saruta, Takao Itoh, Hiroshi |
| description | The nonlinearity of cardiovascular regulation is higher in normal physiology, whereas several diseases are characterized by a reduction in this nonlinearity. Reduced nonlinearity of heart rate regulation is a robust risk factor for high mortality in patients with myocardial infarction. We investigated the changes in linear and nonlinear correlations of cardiovascular regulation after administering drugs in hypertensive diabetic rats. Type 1 diabetes was induced in rats by intraperitoneally injecting spontaneously hypertensive rats with streptozotocin. The animals were then divided into 4 groups and each group was given vehicle, candesartan, amlodipine, or insulin for 2 weeks. Blood pressure, heart rate, renal sympathetic nerve activity, and renal blood flow were simultaneously recorded in the conscious state, and the linear and nonlinear correlations were compared by using coherence and the mutual information method. Candesartan and amlodipine decreased blood pressure to a similar extent, but renal sympathetic nerve activity was significantly lower in the candesartan group than in the vehicle group. The renal sympathetic nerve activity in the insulin group was also lower than in the vehicle group. There were no significant differences in linear correlation among the 4 groups. In contrast, the nonlinear correlations between renal sympathetic nerve activity and blood pressure in the candesartan group and the insulin group were significantly higher than in the vehicle group. Candesartan and insulin decreased renal sympathetic nerve activity and increased the nonlinearity. These results suggest that reducing the activity of renin-angiotensin system and insulin that lowers blood glucose level may improve autonomic nervous system dysfunction and neurohumoral regulation of the cardiovascular system in diabetic hypertensive rats. |
| doi_str_mv | 10.1291/hypres.31.1941 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69806155</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69806155</sourcerecordid><originalsourceid>FETCH-LOGICAL-c516t-d4139ed56baaf634ba874241239888b3e2a25329d85a34fe54677c02104448d83</originalsourceid><addsrcrecordid>eNp1kE1P3DAQhq2Kqiy01x5bn3rL4vHX2ke0UEBCrUTp2XKS2W5Q1htsByn_HkNWcOppZvQ-8x4eQr4CWwK3cLadhohpKWAJVsIHsgAhTSU5yCOyYBZ0ZbXQx-QkpQfGuFEWPpFjsAyUZnxB2rUPLSYfsw-0rPQmpLHvAr3DdmywjOB7-mfaDT5vMXcN_YXxCel5k7unLk-0oNfTgDFjSF0J7stBgV50vn7F73xOn8nHje8TfjnMU_L35-X9-rq6_X11sz6_rRoFOletBGGxVbr2fqOFrL1ZSS6BC2uMqQVyz5XgtjXKC7lBJfVq1TAOTEppWiNOyY-5d4j7xxFTdrsuNdj3PuB-TE5bwzQoVcDlDDZxn1LEjRtit_NxcsDci1c3e3UC3IvX8vDt0DzWO2zf8YPIApzNQCpR-IfRPezHWNyl_1d-nz-Cz2PEt8pt5IwZLlfiGcy4ju8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69806155</pqid></control><display><type>article</type><title>Candesartan and Insulin Reduce Renal Sympathetic Nerve Activity in Hypertensive Type 1 Diabetic Rats</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Takimoto, Chie ; Kumagai, Hiroo ; Osaka, Motohisa ; Sakata, Katsufumi ; Onami, Toshiko ; Kamayachi, Tadashi ; Iigaya, Kamon ; Hayashi, Koichi ; Saruta, Takao ; Itoh, Hiroshi</creator><creatorcontrib>Takimoto, Chie ; Kumagai, Hiroo ; Osaka, Motohisa ; Sakata, Katsufumi ; Onami, Toshiko ; Kamayachi, Tadashi ; Iigaya, Kamon ; Hayashi, Koichi ; Saruta, Takao ; Itoh, Hiroshi</creatorcontrib><description>The nonlinearity of cardiovascular regulation is higher in normal physiology, whereas several diseases are characterized by a reduction in this nonlinearity. Reduced nonlinearity of heart rate regulation is a robust risk factor for high mortality in patients with myocardial infarction. We investigated the changes in linear and nonlinear correlations of cardiovascular regulation after administering drugs in hypertensive diabetic rats. Type 1 diabetes was induced in rats by intraperitoneally injecting spontaneously hypertensive rats with streptozotocin. The animals were then divided into 4 groups and each group was given vehicle, candesartan, amlodipine, or insulin for 2 weeks. Blood pressure, heart rate, renal sympathetic nerve activity, and renal blood flow were simultaneously recorded in the conscious state, and the linear and nonlinear correlations were compared by using coherence and the mutual information method. Candesartan and amlodipine decreased blood pressure to a similar extent, but renal sympathetic nerve activity was significantly lower in the candesartan group than in the vehicle group. The renal sympathetic nerve activity in the insulin group was also lower than in the vehicle group. There were no significant differences in linear correlation among the 4 groups. In contrast, the nonlinear correlations between renal sympathetic nerve activity and blood pressure in the candesartan group and the insulin group were significantly higher than in the vehicle group. Candesartan and insulin decreased renal sympathetic nerve activity and increased the nonlinearity. These results suggest that reducing the activity of renin-angiotensin system and insulin that lowers blood glucose level may improve autonomic nervous system dysfunction and neurohumoral regulation of the cardiovascular system in diabetic hypertensive rats.</description><identifier>ISSN: 0916-9636</identifier><identifier>EISSN: 1348-4214</identifier><identifier>DOI: 10.1291/hypres.31.1941</identifier><identifier>PMID: 19015602</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Angiotensin II Type 1 Receptor Blockers - pharmacology ; Animals ; Benzimidazoles - pharmacology ; Blood Glucose - drug effects ; Blood Pressure - drug effects ; Body Weight - drug effects ; Diabetes Mellitus, Experimental - complications ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Type 1 - complications ; Diabetes Mellitus, Type 1 - drug therapy ; Drug Therapy, Combination ; Geriatrics/Gerontology ; Health Promotion and Disease Prevention ; Heart Rate - drug effects ; Hyperglycemia - complications ; Hyperglycemia - drug therapy ; Hypertension, Renal - complications ; Hypertension, Renal - drug therapy ; Hypoglycemic Agents - pharmacology ; Insulin - pharmacology ; Internal Medicine ; Kidney - innervation ; Linear Models ; Male ; Medicine ; Medicine & Public Health ; Models, Cardiovascular ; Nonlinear Dynamics ; Obstetrics/Perinatology/Midwifery ; original-article ; Public Health ; Rats ; Rats, Inbred SHR ; Sympathetic Nervous System - drug effects ; Tetrazoles - pharmacology</subject><ispartof>Hypertension research, 2008-10, Vol.31 (10), p.1941-1951</ispartof><rights>The Japanese Society of Hypertension 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c516t-d4139ed56baaf634ba874241239888b3e2a25329d85a34fe54677c02104448d83</citedby><cites>FETCH-LOGICAL-c516t-d4139ed56baaf634ba874241239888b3e2a25329d85a34fe54677c02104448d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19015602$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takimoto, Chie</creatorcontrib><creatorcontrib>Kumagai, Hiroo</creatorcontrib><creatorcontrib>Osaka, Motohisa</creatorcontrib><creatorcontrib>Sakata, Katsufumi</creatorcontrib><creatorcontrib>Onami, Toshiko</creatorcontrib><creatorcontrib>Kamayachi, Tadashi</creatorcontrib><creatorcontrib>Iigaya, Kamon</creatorcontrib><creatorcontrib>Hayashi, Koichi</creatorcontrib><creatorcontrib>Saruta, Takao</creatorcontrib><creatorcontrib>Itoh, Hiroshi</creatorcontrib><title>Candesartan and Insulin Reduce Renal Sympathetic Nerve Activity in Hypertensive Type 1 Diabetic Rats</title><title>Hypertension research</title><addtitle>Hypertens Res</addtitle><addtitle>Hypertens Res</addtitle><description>The nonlinearity of cardiovascular regulation is higher in normal physiology, whereas several diseases are characterized by a reduction in this nonlinearity. Reduced nonlinearity of heart rate regulation is a robust risk factor for high mortality in patients with myocardial infarction. We investigated the changes in linear and nonlinear correlations of cardiovascular regulation after administering drugs in hypertensive diabetic rats. Type 1 diabetes was induced in rats by intraperitoneally injecting spontaneously hypertensive rats with streptozotocin. The animals were then divided into 4 groups and each group was given vehicle, candesartan, amlodipine, or insulin for 2 weeks. Blood pressure, heart rate, renal sympathetic nerve activity, and renal blood flow were simultaneously recorded in the conscious state, and the linear and nonlinear correlations were compared by using coherence and the mutual information method. Candesartan and amlodipine decreased blood pressure to a similar extent, but renal sympathetic nerve activity was significantly lower in the candesartan group than in the vehicle group. The renal sympathetic nerve activity in the insulin group was also lower than in the vehicle group. There were no significant differences in linear correlation among the 4 groups. In contrast, the nonlinear correlations between renal sympathetic nerve activity and blood pressure in the candesartan group and the insulin group were significantly higher than in the vehicle group. Candesartan and insulin decreased renal sympathetic nerve activity and increased the nonlinearity. These results suggest that reducing the activity of renin-angiotensin system and insulin that lowers blood glucose level may improve autonomic nervous system dysfunction and neurohumoral regulation of the cardiovascular system in diabetic hypertensive rats.</description><subject>Angiotensin II Type 1 Receptor Blockers - pharmacology</subject><subject>Animals</subject><subject>Benzimidazoles - pharmacology</subject><subject>Blood Glucose - drug effects</subject><subject>Blood Pressure - drug effects</subject><subject>Body Weight - drug effects</subject><subject>Diabetes Mellitus, Experimental - complications</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetes Mellitus, Type 1 - complications</subject><subject>Diabetes Mellitus, Type 1 - drug therapy</subject><subject>Drug Therapy, Combination</subject><subject>Geriatrics/Gerontology</subject><subject>Health Promotion and Disease Prevention</subject><subject>Heart Rate - drug effects</subject><subject>Hyperglycemia - complications</subject><subject>Hyperglycemia - drug therapy</subject><subject>Hypertension, Renal - complications</subject><subject>Hypertension, Renal - drug therapy</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Insulin - pharmacology</subject><subject>Internal Medicine</subject><subject>Kidney - innervation</subject><subject>Linear Models</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Models, Cardiovascular</subject><subject>Nonlinear Dynamics</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>original-article</subject><subject>Public Health</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Sympathetic Nervous System - drug effects</subject><subject>Tetrazoles - pharmacology</subject><issn>0916-9636</issn><issn>1348-4214</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1P3DAQhq2Kqiy01x5bn3rL4vHX2ke0UEBCrUTp2XKS2W5Q1htsByn_HkNWcOppZvQ-8x4eQr4CWwK3cLadhohpKWAJVsIHsgAhTSU5yCOyYBZ0ZbXQx-QkpQfGuFEWPpFjsAyUZnxB2rUPLSYfsw-0rPQmpLHvAr3DdmywjOB7-mfaDT5vMXcN_YXxCel5k7unLk-0oNfTgDFjSF0J7stBgV50vn7F73xOn8nHje8TfjnMU_L35-X9-rq6_X11sz6_rRoFOletBGGxVbr2fqOFrL1ZSS6BC2uMqQVyz5XgtjXKC7lBJfVq1TAOTEppWiNOyY-5d4j7xxFTdrsuNdj3PuB-TE5bwzQoVcDlDDZxn1LEjRtit_NxcsDci1c3e3UC3IvX8vDt0DzWO2zf8YPIApzNQCpR-IfRPezHWNyl_1d-nz-Cz2PEt8pt5IwZLlfiGcy4ju8</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>Takimoto, Chie</creator><creator>Kumagai, Hiroo</creator><creator>Osaka, Motohisa</creator><creator>Sakata, Katsufumi</creator><creator>Onami, Toshiko</creator><creator>Kamayachi, Tadashi</creator><creator>Iigaya, Kamon</creator><creator>Hayashi, Koichi</creator><creator>Saruta, Takao</creator><creator>Itoh, Hiroshi</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20081001</creationdate><title>Candesartan and Insulin Reduce Renal Sympathetic Nerve Activity in Hypertensive Type 1 Diabetic Rats</title><author>Takimoto, Chie ; Kumagai, Hiroo ; Osaka, Motohisa ; Sakata, Katsufumi ; Onami, Toshiko ; Kamayachi, Tadashi ; Iigaya, Kamon ; Hayashi, Koichi ; Saruta, Takao ; Itoh, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c516t-d4139ed56baaf634ba874241239888b3e2a25329d85a34fe54677c02104448d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Angiotensin II Type 1 Receptor Blockers - pharmacology</topic><topic>Animals</topic><topic>Benzimidazoles - pharmacology</topic><topic>Blood Glucose - drug effects</topic><topic>Blood Pressure - drug effects</topic><topic>Body Weight - drug effects</topic><topic>Diabetes Mellitus, Experimental - complications</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Diabetes Mellitus, Type 1 - complications</topic><topic>Diabetes Mellitus, Type 1 - drug therapy</topic><topic>Drug Therapy, Combination</topic><topic>Geriatrics/Gerontology</topic><topic>Health Promotion and Disease Prevention</topic><topic>Heart Rate - drug effects</topic><topic>Hyperglycemia - complications</topic><topic>Hyperglycemia - drug therapy</topic><topic>Hypertension, Renal - complications</topic><topic>Hypertension, Renal - drug therapy</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Insulin - pharmacology</topic><topic>Internal Medicine</topic><topic>Kidney - innervation</topic><topic>Linear Models</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Models, Cardiovascular</topic><topic>Nonlinear Dynamics</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>original-article</topic><topic>Public Health</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>Sympathetic Nervous System - drug effects</topic><topic>Tetrazoles - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takimoto, Chie</creatorcontrib><creatorcontrib>Kumagai, Hiroo</creatorcontrib><creatorcontrib>Osaka, Motohisa</creatorcontrib><creatorcontrib>Sakata, Katsufumi</creatorcontrib><creatorcontrib>Onami, Toshiko</creatorcontrib><creatorcontrib>Kamayachi, Tadashi</creatorcontrib><creatorcontrib>Iigaya, Kamon</creatorcontrib><creatorcontrib>Hayashi, Koichi</creatorcontrib><creatorcontrib>Saruta, Takao</creatorcontrib><creatorcontrib>Itoh, Hiroshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takimoto, Chie</au><au>Kumagai, Hiroo</au><au>Osaka, Motohisa</au><au>Sakata, Katsufumi</au><au>Onami, Toshiko</au><au>Kamayachi, Tadashi</au><au>Iigaya, Kamon</au><au>Hayashi, Koichi</au><au>Saruta, Takao</au><au>Itoh, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Candesartan and Insulin Reduce Renal Sympathetic Nerve Activity in Hypertensive Type 1 Diabetic Rats</atitle><jtitle>Hypertension research</jtitle><stitle>Hypertens Res</stitle><addtitle>Hypertens Res</addtitle><date>2008-10-01</date><risdate>2008</risdate><volume>31</volume><issue>10</issue><spage>1941</spage><epage>1951</epage><pages>1941-1951</pages><issn>0916-9636</issn><eissn>1348-4214</eissn><abstract>The nonlinearity of cardiovascular regulation is higher in normal physiology, whereas several diseases are characterized by a reduction in this nonlinearity. Reduced nonlinearity of heart rate regulation is a robust risk factor for high mortality in patients with myocardial infarction. We investigated the changes in linear and nonlinear correlations of cardiovascular regulation after administering drugs in hypertensive diabetic rats. Type 1 diabetes was induced in rats by intraperitoneally injecting spontaneously hypertensive rats with streptozotocin. The animals were then divided into 4 groups and each group was given vehicle, candesartan, amlodipine, or insulin for 2 weeks. Blood pressure, heart rate, renal sympathetic nerve activity, and renal blood flow were simultaneously recorded in the conscious state, and the linear and nonlinear correlations were compared by using coherence and the mutual information method. Candesartan and amlodipine decreased blood pressure to a similar extent, but renal sympathetic nerve activity was significantly lower in the candesartan group than in the vehicle group. The renal sympathetic nerve activity in the insulin group was also lower than in the vehicle group. There were no significant differences in linear correlation among the 4 groups. In contrast, the nonlinear correlations between renal sympathetic nerve activity and blood pressure in the candesartan group and the insulin group were significantly higher than in the vehicle group. Candesartan and insulin decreased renal sympathetic nerve activity and increased the nonlinearity. These results suggest that reducing the activity of renin-angiotensin system and insulin that lowers blood glucose level may improve autonomic nervous system dysfunction and neurohumoral regulation of the cardiovascular system in diabetic hypertensive rats.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>19015602</pmid><doi>10.1291/hypres.31.1941</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0916-9636 |
| ispartof | Hypertension research, 2008-10, Vol.31 (10), p.1941-1951 |
| issn | 0916-9636 1348-4214 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69806155 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Angiotensin II Type 1 Receptor Blockers - pharmacology Animals Benzimidazoles - pharmacology Blood Glucose - drug effects Blood Pressure - drug effects Body Weight - drug effects Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - drug therapy Drug Therapy, Combination Geriatrics/Gerontology Health Promotion and Disease Prevention Heart Rate - drug effects Hyperglycemia - complications Hyperglycemia - drug therapy Hypertension, Renal - complications Hypertension, Renal - drug therapy Hypoglycemic Agents - pharmacology Insulin - pharmacology Internal Medicine Kidney - innervation Linear Models Male Medicine Medicine & Public Health Models, Cardiovascular Nonlinear Dynamics Obstetrics/Perinatology/Midwifery original-article Public Health Rats Rats, Inbred SHR Sympathetic Nervous System - drug effects Tetrazoles - pharmacology |
| title | Candesartan and Insulin Reduce Renal Sympathetic Nerve Activity in Hypertensive Type 1 Diabetic Rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T14%3A27%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Candesartan%20and%20Insulin%20Reduce%20Renal%20Sympathetic%20Nerve%20Activity%20in%20Hypertensive%20Type%201%20Diabetic%20Rats&rft.jtitle=Hypertension%20research&rft.au=Takimoto,%20Chie&rft.date=2008-10-01&rft.volume=31&rft.issue=10&rft.spage=1941&rft.epage=1951&rft.pages=1941-1951&rft.issn=0916-9636&rft.eissn=1348-4214&rft_id=info:doi/10.1291/hypres.31.1941&rft_dat=%3Cproquest_cross%3E69806155%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69806155&rft_id=info:pmid/19015602&rfr_iscdi=true |