Recent Progress in the Development of Terumo Implantable Left Ventricular Assist System
The research group of the Terumo Corporation, the NTN Corporation, and Setsunan University (T. Akamatsu) has been developing an implantable left ventricular assist system (ILVAS) featuring a centrifugal blood pump with a magnetically suspended impeller (MSCP). The impeller of the MSCP is suspended b...
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| Veröffentlicht in: | ASAIO journal (1992) 1999-05, Vol.45 (3), p.199-203 |
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| container_title | ASAIO journal (1992) |
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| creator | NOJIRI, CHISATO KIJIMA, TOSHIHIKO MAEKAWA, JUN HORIUCHI, KUNIO KIDO, TAKAYUKI SUGIYAMA, TOMOKO MORI, TAKEHISA SUGIURA, NAOYA ASADA, TAKEHIKO SHIMANE, HIROSHI OZAKI, TAKAYOSHI SUZUKI, MINORU AKAMATSU, TERUAKI AKUTSU, TETSUZO |
| description | The research group of the Terumo Corporation, the NTN Corporation, and Setsunan University (T. Akamatsu) has been developing an implantable left ventricular assist system (ILVAS) featuring a centrifugal blood pump with a magnetically suspended impeller (MSCP). The impeller of the MSCP is suspended by a magnetic bearing, providing contact-free rotation of the impeller inside the pump housing. Thus the MSCP is expected to provide years of long-term durability. Ex vivo chronic sheep experiments using the extracorporeal model (Model I) demonstrated long-term durability, non-thrombogenicity, and a low hemolysis rate (plasma free Hb |
| doi_str_mv | 10.1097/00002480-199905000-00018 |
| format | Article |
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Akamatsu) has been developing an implantable left ventricular assist system (ILVAS) featuring a centrifugal blood pump with a magnetically suspended impeller (MSCP). The impeller of the MSCP is suspended by a magnetic bearing, providing contact-free rotation of the impeller inside the pump housing. Thus the MSCP is expected to provide years of long-term durability. Ex vivo chronic sheep experiments using the extracorporeal model (Model I) demonstrated long-term durability, non-thrombogenicity, and a low hemolysis rate (plasma free Hb <6 mg/dl) for more than 2 years. The prototype implantable model (Model II; 196 ml, 400 g) was evaluated ex vivo in 2 sheep and intrathoracically implanted in a small sheep (45 kg). These experiments were terminated at 70, 79, and 17 days, respectively, because of blood leakage through the connector system within the housing of Model II. There was no thrombus formation on the retrieved pump surfaces. A new connector system was introduced to the Model II pump (modified Model II), and the pump was intrathoracically implanted in a sheep. Pump flow rate was maintained at 3–7 L/min at 1700–1800 rpm. The temperature elevation on the surfaces of the motor and the electromagnet inside the pump casing was kept less than 6°C. The temperature of the tissue adjacent to the pump casing became normal 10 days postoperatively. The sheep survived for more than 5 months without any sign of mechanical failure or thromboembolic complication. In vitro real-time endurance tests of motor bearings made of stainless steel and silicone nitride have been conducted for more than 1 year without any sign of bearing wear. The next prototype system (Model III), with an implantable controller and a new MSCP with reduced input power, has been developed with a view toward a totally implantable LVAS. ASAIO Journal 1999; 45:199–203.</description><identifier>ISSN: 1058-2916</identifier><identifier>EISSN: 1538-943X</identifier><identifier>DOI: 10.1097/00002480-199905000-00018</identifier><identifier>PMID: 10360723</identifier><identifier>CODEN: AJOUET</identifier><language>eng</language><publisher>Philadelphia, PA: Copyright by the American Society for Artificial Internal Organs</publisher><subject>Alanine Transaminase - blood ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Aspartate Aminotransferases - blood ; Biological and medical sciences ; Blood ; Creatinine - blood ; Durability ; Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care ; Equipment Design ; Heart-Assist Devices ; Hemodynamics ; Hemoglobins - metabolism ; Implants (surgical) ; Intensive care medicine ; Leakage (fluid) ; Materials Testing ; Medical sciences ; Microscopy, Electron, Scanning ; Prosthesis Implantation ; Research and development management ; Sheep ; Temperature ; Tissue</subject><ispartof>ASAIO journal (1992), 1999-05, Vol.45 (3), p.199-203</ispartof><rights>Copyright © 1999 by the American Society for Artificial Internal Organs</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5348-c276169908dfabaf34f73e2750f92c7e4dee10945f28ffd06d906837fa121b5a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf><![CDATA[$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&PDF=y&D=ovft&AN=00002480-199905000-00018$$EPDF$$P50$$Gwolterskluwer$$H]]></linktopdf><linktohtml>$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00002480-199905000-00018$$EHTML$$P50$$Gwolterskluwer$$H</linktohtml><link.rule.ids>314,780,784,4609,27924,27925,64666,65461</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1789150$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10360723$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NOJIRI, CHISATO</creatorcontrib><creatorcontrib>KIJIMA, TOSHIHIKO</creatorcontrib><creatorcontrib>MAEKAWA, JUN</creatorcontrib><creatorcontrib>HORIUCHI, KUNIO</creatorcontrib><creatorcontrib>KIDO, TAKAYUKI</creatorcontrib><creatorcontrib>SUGIYAMA, TOMOKO</creatorcontrib><creatorcontrib>MORI, TAKEHISA</creatorcontrib><creatorcontrib>SUGIURA, NAOYA</creatorcontrib><creatorcontrib>ASADA, TAKEHIKO</creatorcontrib><creatorcontrib>SHIMANE, HIROSHI</creatorcontrib><creatorcontrib>OZAKI, TAKAYOSHI</creatorcontrib><creatorcontrib>SUZUKI, MINORU</creatorcontrib><creatorcontrib>AKAMATSU, TERUAKI</creatorcontrib><creatorcontrib>AKUTSU, TETSUZO</creatorcontrib><title>Recent Progress in the Development of Terumo Implantable Left Ventricular Assist System</title><title>ASAIO journal (1992)</title><addtitle>ASAIO J</addtitle><description>The research group of the Terumo Corporation, the NTN Corporation, and Setsunan University (T. Akamatsu) has been developing an implantable left ventricular assist system (ILVAS) featuring a centrifugal blood pump with a magnetically suspended impeller (MSCP). The impeller of the MSCP is suspended by a magnetic bearing, providing contact-free rotation of the impeller inside the pump housing. Thus the MSCP is expected to provide years of long-term durability. Ex vivo chronic sheep experiments using the extracorporeal model (Model I) demonstrated long-term durability, non-thrombogenicity, and a low hemolysis rate (plasma free Hb <6 mg/dl) for more than 2 years. The prototype implantable model (Model II; 196 ml, 400 g) was evaluated ex vivo in 2 sheep and intrathoracically implanted in a small sheep (45 kg). These experiments were terminated at 70, 79, and 17 days, respectively, because of blood leakage through the connector system within the housing of Model II. There was no thrombus formation on the retrieved pump surfaces. A new connector system was introduced to the Model II pump (modified Model II), and the pump was intrathoracically implanted in a sheep. Pump flow rate was maintained at 3–7 L/min at 1700–1800 rpm. The temperature elevation on the surfaces of the motor and the electromagnet inside the pump casing was kept less than 6°C. The temperature of the tissue adjacent to the pump casing became normal 10 days postoperatively. The sheep survived for more than 5 months without any sign of mechanical failure or thromboembolic complication. In vitro real-time endurance tests of motor bearings made of stainless steel and silicone nitride have been conducted for more than 1 year without any sign of bearing wear. The next prototype system (Model III), with an implantable controller and a new MSCP with reduced input power, has been developed with a view toward a totally implantable LVAS. ASAIO Journal 1999; 45:199–203.</description><subject>Alanine Transaminase - blood</subject><subject>Anesthesia. 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Coronary intensive care</subject><subject>Equipment Design</subject><subject>Heart-Assist Devices</subject><subject>Hemodynamics</subject><subject>Hemoglobins - metabolism</subject><subject>Implants (surgical)</subject><subject>Intensive care medicine</subject><subject>Leakage (fluid)</subject><subject>Materials Testing</subject><subject>Medical sciences</subject><subject>Microscopy, Electron, Scanning</subject><subject>Prosthesis Implantation</subject><subject>Research and development management</subject><subject>Sheep</subject><subject>Temperature</subject><subject>Tissue</subject><issn>1058-2916</issn><issn>1538-943X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVmPFCEQgInRuIf-BcOD8a2Vs4HHzXptMolG1-ONMHThtNLTI0W72X-_rDMeL0YSAqS-KqgPQihnTzlz5hlrQyjLOu6cY7qduja5vUOOuZa2c0p-vtv2TNtOON4fkRPEr43QUvL75Igz2TMj5DH59A4ibCt9W-YvBRDpuKV1A_Q5_IA876bb2JzoJZRlmunFtMthW8M6A11BqvRji5cxLjkUeoY4YqXvr7HC9IDcSyEjPDysp-TDyxeX56-71ZtXF-dnqy5qqWwXhel533qwQwrrkKRKRoIwmiUnogE1ALSOlU7CpjSwfnCst9KkwAVf6yBPyZN93V2Zvy-A1U8jRsjtmTAv6HtnmTJO_hcUXHGtdd9AuwdjmRELJL8r4xTKtefM39r3v-z73_b9T_st9dHhjmU9wfBX4l53Ax4fgIAx5FTCNo74hzPWcc0apvbY1ZwrFPyWlysofgMh143_1-fLGxuMm9E</recordid><startdate>199905</startdate><enddate>199905</enddate><creator>NOJIRI, CHISATO</creator><creator>KIJIMA, TOSHIHIKO</creator><creator>MAEKAWA, JUN</creator><creator>HORIUCHI, KUNIO</creator><creator>KIDO, TAKAYUKI</creator><creator>SUGIYAMA, TOMOKO</creator><creator>MORI, TAKEHISA</creator><creator>SUGIURA, NAOYA</creator><creator>ASADA, TAKEHIKO</creator><creator>SHIMANE, HIROSHI</creator><creator>OZAKI, TAKAYOSHI</creator><creator>SUZUKI, MINORU</creator><creator>AKAMATSU, TERUAKI</creator><creator>AKUTSU, TETSUZO</creator><general>Copyright by the American Society for Artificial Internal Organs</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199905</creationdate><title>Recent Progress in the Development of Terumo Implantable Left Ventricular Assist System</title><author>NOJIRI, CHISATO ; KIJIMA, TOSHIHIKO ; MAEKAWA, JUN ; HORIUCHI, KUNIO ; KIDO, TAKAYUKI ; SUGIYAMA, TOMOKO ; MORI, TAKEHISA ; SUGIURA, NAOYA ; ASADA, TAKEHIKO ; SHIMANE, HIROSHI ; OZAKI, TAKAYOSHI ; SUZUKI, MINORU ; AKAMATSU, TERUAKI ; AKUTSU, TETSUZO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5348-c276169908dfabaf34f73e2750f92c7e4dee10945f28ffd06d906837fa121b5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Alanine Transaminase - blood</topic><topic>Anesthesia. 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Akamatsu) has been developing an implantable left ventricular assist system (ILVAS) featuring a centrifugal blood pump with a magnetically suspended impeller (MSCP). The impeller of the MSCP is suspended by a magnetic bearing, providing contact-free rotation of the impeller inside the pump housing. Thus the MSCP is expected to provide years of long-term durability. Ex vivo chronic sheep experiments using the extracorporeal model (Model I) demonstrated long-term durability, non-thrombogenicity, and a low hemolysis rate (plasma free Hb <6 mg/dl) for more than 2 years. The prototype implantable model (Model II; 196 ml, 400 g) was evaluated ex vivo in 2 sheep and intrathoracically implanted in a small sheep (45 kg). These experiments were terminated at 70, 79, and 17 days, respectively, because of blood leakage through the connector system within the housing of Model II. There was no thrombus formation on the retrieved pump surfaces. A new connector system was introduced to the Model II pump (modified Model II), and the pump was intrathoracically implanted in a sheep. Pump flow rate was maintained at 3–7 L/min at 1700–1800 rpm. The temperature elevation on the surfaces of the motor and the electromagnet inside the pump casing was kept less than 6°C. The temperature of the tissue adjacent to the pump casing became normal 10 days postoperatively. The sheep survived for more than 5 months without any sign of mechanical failure or thromboembolic complication. In vitro real-time endurance tests of motor bearings made of stainless steel and silicone nitride have been conducted for more than 1 year without any sign of bearing wear. The next prototype system (Model III), with an implantable controller and a new MSCP with reduced input power, has been developed with a view toward a totally implantable LVAS. 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| fulltext | fulltext |
| identifier | ISSN: 1058-2916 |
| ispartof | ASAIO journal (1992), 1999-05, Vol.45 (3), p.199-203 |
| issn | 1058-2916 1538-943X |
| language | eng |
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| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Alanine Transaminase - blood Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Aspartate Aminotransferases - blood Biological and medical sciences Blood Creatinine - blood Durability Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care Equipment Design Heart-Assist Devices Hemodynamics Hemoglobins - metabolism Implants (surgical) Intensive care medicine Leakage (fluid) Materials Testing Medical sciences Microscopy, Electron, Scanning Prosthesis Implantation Research and development management Sheep Temperature Tissue |
| title | Recent Progress in the Development of Terumo Implantable Left Ventricular Assist System |
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