Human polymorphonuclear leukocytes produce IL-12, TNF-alpha, and the chemokines macrophage-inflammatory protein-1 alpha and -1 beta in response to Toxoplasma gondii antigens

The induction of a type 1 inflammatory cytokine response is a key event in the initiation of immunity to Toxoplasma gondii. Because polymorphonuclear leukocytes rapidly respond to infection by exiting the peripheral blood and accumulating at a site of infection, we sought to determine whether these...

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Veröffentlicht in:	The Journal of immunology (1950) 1999-06, Vol.162 (12), p.7369-7375
Hauptverfasser:	Bliss, S K, Marshall, A J, Zhang, Y, Denkers, E Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Protozoan - immunology Cell Separation Chemokine CCL4 Humans Interleukin-12 - biosynthesis Macrophage Inflammatory Proteins - biosynthesis Neutrophils - immunology Neutrophils - metabolism Neutrophils - parasitology Toxoplasma - immunology Toxoplasma gondii Toxoplasmosis - immunology Toxoplasmosis - metabolism Tumor Necrosis Factor-alpha - biosynthesis
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