Expression of Human DNA Topoisomerase II-α in Squamous Cell Carcinoma of the Larynx and Its Correlation With Clinicopathologic Variables

The aggressiveness of laryngeal squamous cell carcinoma (SCC) is unpredictable. Topoisomerase (Topo) II-alpha is an essential nuclear enzyme; its expression rises at the end of the S-G2/M phase and drops at completion of mitosis. This study sought to determine if Topo II-alpha expression can serve a...

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Veröffentlicht in:	American journal of clinical pathology 2008-12, Vol.130 (6), p.934-939
Hauptverfasser:	SHVERO, Jacob, KOREN, Rumelia, SHVILI, Itzhak, YANIV, Eitan, SADOV, Rima, HADAR, Tuvia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antigens, Neoplasm - biosynthesis Antigens, Neoplasm - genetics Biological and medical sciences Biomarkers, Tumor - biosynthesis Dermatology Disease-Free Survival DNA Topoisomerases, Type II - biosynthesis DNA Topoisomerases, Type II - genetics DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics Female Humans Investigative techniques, diagnostic techniques (general aspects) Laryngeal Neoplasms - metabolism Laryngeal Neoplasms - pathology Male Medical sciences Middle Aged Neoplasms, Squamous Cell - metabolism Neoplasms, Squamous Cell - pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Prognosis Tumors of the skin and soft tissue. Premalignant lesions
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