Efficient inhibition of muscle and liver glycogen phosphorylases by a new glucopyranosylidene-spiro-thiohydantoin

Reaction of C-(1- bromo-1-deoxy-β- d-glucopyranosyl)formamide 2 with thiocyanate ions was the key step of a short synthesis of d-glucopyranosylidene-spiro-thiohydantoin 7 which proved to be a potent inhibitor of muscle and liver glycogen phosphorylases. Graphic

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 1999-05, Vol.9 (10), p.1385-1390
Hauptverfasser:	Ősz, Erzsébet, Somsák, László, Szilágyi, László, Kovács, László, Docsa, Tibor, Tóth, Béla, Gergely, Pál
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Enzyme Inhibitors - pharmacology General and cellular metabolism. Vitamins Kinetics Liver - drug effects Liver - enzymology Medical sciences Muscle, Skeletal - drug effects Muscle, Skeletal - enzymology Pharmacology. Drug treatments Phosphorylases - antagonists & inhibitors Rabbits
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Beschreibung
Zusammenfassung:	Reaction of C-(1- bromo-1-deoxy-β- d-glucopyranosyl)formamide 2 with thiocyanate ions was the key step of a short synthesis of d-glucopyranosylidene-spiro-thiohydantoin 7 which proved to be a potent inhibitor of muscle and liver glycogen phosphorylases. Graphic
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(99)00192-4