DNA methylation by tert-butyl hydroperoxide-iron (II) : A role for the transition metal ion in the production of DNA base adducts

Metabolic degradation of both endogenous and exogenous peroxides is associated with the etiology of several diseases including cancer. Tert-butyl hydroperoxide (TBHP) has been widely employed as a model compound to study the cytotoxicity and promoting effects of organic peroxides. Recently, we repor...

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Veröffentlicht in:	Chemico-biological interactions 1999-04, Vol.118 (2), p.141-149
Hauptverfasser:	Hix, Sonia, Augusto, Ohara
Format:	Artikel
Sprache:	eng
Schlagworte:	7-Methylguanine 8-Methylguanine Adenine - analogs & derivatives Adenine - chemistry Animals Cattle Chelating Agents - chemistry Copper - chemistry DNA Adducts - chemistry DNA Methylation Electron Spin Resonance Spectroscopy Free Radicals - chemistry Guanine - analogs & derivatives Guanine - chemistry Iron - chemistry Methyl radicals Molecular Structure Tert-butyl hydroperoxide tert-Butylhydroperoxide - chemistry
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