Second-trimester maternal serum inhibin-A screening for fetal Down syndrome in Asian women
Case–control studies in the Caucasian population showed that maternal serum inhibin‐A is elevated in Down syndrome pregnancies and may be a useful second‐trimester marker in addition to human chorionic gonadotrophin (hCG) and alpha‐fetoprotein (AFP). Data in the Asian population are lacking. We meas...
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| Veröffentlicht in: | Prenatal diagnosis 1999-05, Vol.19 (5), p.463-467 |
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| description | Case–control studies in the Caucasian population showed that maternal serum inhibin‐A is elevated in Down syndrome pregnancies and may be a useful second‐trimester marker in addition to human chorionic gonadotrophin (hCG) and alpha‐fetoprotein (AFP). Data in the Asian population are lacking. We measured inhibin‐A levels in the stored maternal sera of 49 Down syndrome pregnancies and 341 controls with a commercially available assay and expressed them as the multiples of the median of the gestational week. The log means and standard deviations for case and control inhibin‐A MOMs were 0.209, 0.226, and 0.002 and 0.177, respectively. Median inhibin‐A MOM in Down syndrome cases was elevated to 1.62 (95 per cent confidence interval, 1.29–1.82). 36 per cent of Down syndrome cases were expected to be detected at a 5 per cent false‐positive rate. However, inhibin‐A MOMs were strongly correlated with hCG MOMs in the cases (r=0.73, p |
| doi_str_mv | 10.1002/(SICI)1097-0223(199905)19:5<463::AID-PD574>3.0.CO;2-Q |
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Data in the Asian population are lacking. We measured inhibin‐A levels in the stored maternal sera of 49 Down syndrome pregnancies and 341 controls with a commercially available assay and expressed them as the multiples of the median of the gestational week. The log means and standard deviations for case and control inhibin‐A MOMs were 0.209, 0.226, and 0.002 and 0.177, respectively. Median inhibin‐A MOM in Down syndrome cases was elevated to 1.62 (95 per cent confidence interval, 1.29–1.82). 36 per cent of Down syndrome cases were expected to be detected at a 5 per cent false‐positive rate. However, inhibin‐A MOMs were strongly correlated with hCG MOMs in the cases (r=0.73, p<0.001) and the controls (r=0.56, p<0.001). This will diminish the value of adding inhibin‐A to the existing hCG and AFP screening protocol. Copyright © 1999 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0197-3851</identifier><identifier>EISSN: 1097-0223</identifier><identifier>DOI: 10.1002/(SICI)1097-0223(199905)19:5<463::AID-PD574>3.0.CO;2-Q</identifier><identifier>PMID: 10360516</identifier><identifier>CODEN: PRDIDM</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adult ; alpha-Fetoproteins - analysis ; Asian ; Asian Continental Ancestry Group ; Biological and medical sciences ; Biomarkers - blood ; Case-Control Studies ; Chorionic Gonadotropin - blood ; Down syndrome ; Down Syndrome - blood ; Down Syndrome - diagnosis ; Down Syndrome - embryology ; Female ; Fetal Diseases - blood ; Fetal Diseases - diagnosis ; Gynecology. Andrology. Obstetrics ; Humans ; inhibin-A ; Inhibins - blood ; Management. Prenatal diagnosis ; Medical sciences ; Predictive Value of Tests ; Pregnancy ; Pregnancy Trimester, Second ; Pregnancy. Fetus. Placenta ; Prenatal Diagnosis ; screening</subject><ispartof>Prenatal diagnosis, 1999-05, Vol.19 (5), p.463-467</ispartof><rights>Copyright © 1999 John Wiley & Sons, Ltd.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4314-575fe3f659518882573de1a0b55d1569651ff8c70ce9032662e7e17dd8fb12253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291097-0223%28199905%2919%3A5%3C463%3A%3AAID-PD574%3E3.0.CO%3B2-Q$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291097-0223%28199905%2919%3A5%3C463%3A%3AAID-PD574%3E3.0.CO%3B2-Q$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1779125$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10360516$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lam, Yung Hang</creatorcontrib><creatorcontrib>Tang, Mary Hoi Yin</creatorcontrib><title>Second-trimester maternal serum inhibin-A screening for fetal Down syndrome in Asian women</title><title>Prenatal diagnosis</title><addtitle>Prenat. Diagn</addtitle><description>Case–control studies in the Caucasian population showed that maternal serum inhibin‐A is elevated in Down syndrome pregnancies and may be a useful second‐trimester marker in addition to human chorionic gonadotrophin (hCG) and alpha‐fetoprotein (AFP). Data in the Asian population are lacking. We measured inhibin‐A levels in the stored maternal sera of 49 Down syndrome pregnancies and 341 controls with a commercially available assay and expressed them as the multiples of the median of the gestational week. The log means and standard deviations for case and control inhibin‐A MOMs were 0.209, 0.226, and 0.002 and 0.177, respectively. Median inhibin‐A MOM in Down syndrome cases was elevated to 1.62 (95 per cent confidence interval, 1.29–1.82). 36 per cent of Down syndrome cases were expected to be detected at a 5 per cent false‐positive rate. However, inhibin‐A MOMs were strongly correlated with hCG MOMs in the cases (r=0.73, p<0.001) and the controls (r=0.56, p<0.001). This will diminish the value of adding inhibin‐A to the existing hCG and AFP screening protocol. Copyright © 1999 John Wiley & Sons, Ltd.</description><subject>Adult</subject><subject>alpha-Fetoproteins - analysis</subject><subject>Asian</subject><subject>Asian Continental Ancestry Group</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>Chorionic Gonadotropin - blood</subject><subject>Down syndrome</subject><subject>Down Syndrome - blood</subject><subject>Down Syndrome - diagnosis</subject><subject>Down Syndrome - embryology</subject><subject>Female</subject><subject>Fetal Diseases - blood</subject><subject>Fetal Diseases - diagnosis</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>inhibin-A</subject><subject>Inhibins - blood</subject><subject>Management. Prenatal diagnosis</subject><subject>Medical sciences</subject><subject>Predictive Value of Tests</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, Second</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Prenatal Diagnosis</subject><subject>screening</subject><issn>0197-3851</issn><issn>1097-0223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1v0zAYhSMEYmXwF1AuENouUvwR23FhSFXKRsVE6caXdvPKTexhljjDblX673GXqiCBxI1f2zo-OudxkpxgNMQIkRdHl9NyeoyRFBkihB5hKSVix1iO2Kuc09FoPJ1kHyZM5K_pEA3L2UuSze8lg_2L-8kA4binBcMHyaMQvkfbgkjxMDnAiHLEMB8kV5e66lydLb1tdVhqn7Yqrk41adB-1abWfbML67JxGiqvtbPuOjWdT41eRs2kW7s0bFztu1ZHbToOVrl0HU_ucfLAqCboJ7t5mHw6ffOxfJudz86m5fg8q3KK84wJZjQ1nEmGi6IgTNBaY4UWjNWYcckZNqaoBKq0RJRwTrTQWNR1YRaYEEYPk-e9763vfqxiCWhtqHTTKKe7VQAuC0TyXNJ9gMp3IXht4Da2Vn4DGMEWOsAWOmwRwhYh9NDjAAYROkCEDnfQgQKCcgYE5tH36S7AatHq-g_XnnIUPNsJVKhUY7xylQ2_dUJIfFfkcy9b20Zv_gr3n2z_itZfROOsN7bxh3_ujZW_AS6oYPDl_Rmckouri_k7Al_pL9Fqt4s</recordid><startdate>199905</startdate><enddate>199905</enddate><creator>Lam, Yung Hang</creator><creator>Tang, Mary Hoi Yin</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199905</creationdate><title>Second-trimester maternal serum inhibin-A screening for fetal Down syndrome in Asian women</title><author>Lam, Yung Hang ; Tang, Mary Hoi Yin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4314-575fe3f659518882573de1a0b55d1569651ff8c70ce9032662e7e17dd8fb12253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>alpha-Fetoproteins - analysis</topic><topic>Asian</topic><topic>Asian Continental Ancestry Group</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>Chorionic Gonadotropin - blood</topic><topic>Down syndrome</topic><topic>Down Syndrome - blood</topic><topic>Down Syndrome - diagnosis</topic><topic>Down Syndrome - embryology</topic><topic>Female</topic><topic>Fetal Diseases - blood</topic><topic>Fetal Diseases - diagnosis</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>inhibin-A</topic><topic>Inhibins - blood</topic><topic>Management. Prenatal diagnosis</topic><topic>Medical sciences</topic><topic>Predictive Value of Tests</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, Second</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Prenatal Diagnosis</topic><topic>screening</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lam, Yung Hang</creatorcontrib><creatorcontrib>Tang, Mary Hoi Yin</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Prenatal diagnosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lam, Yung Hang</au><au>Tang, Mary Hoi Yin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Second-trimester maternal serum inhibin-A screening for fetal Down syndrome in Asian women</atitle><jtitle>Prenatal diagnosis</jtitle><addtitle>Prenat. Diagn</addtitle><date>1999-05</date><risdate>1999</risdate><volume>19</volume><issue>5</issue><spage>463</spage><epage>467</epage><pages>463-467</pages><issn>0197-3851</issn><eissn>1097-0223</eissn><coden>PRDIDM</coden><abstract>Case–control studies in the Caucasian population showed that maternal serum inhibin‐A is elevated in Down syndrome pregnancies and may be a useful second‐trimester marker in addition to human chorionic gonadotrophin (hCG) and alpha‐fetoprotein (AFP). Data in the Asian population are lacking. We measured inhibin‐A levels in the stored maternal sera of 49 Down syndrome pregnancies and 341 controls with a commercially available assay and expressed them as the multiples of the median of the gestational week. The log means and standard deviations for case and control inhibin‐A MOMs were 0.209, 0.226, and 0.002 and 0.177, respectively. Median inhibin‐A MOM in Down syndrome cases was elevated to 1.62 (95 per cent confidence interval, 1.29–1.82). 36 per cent of Down syndrome cases were expected to be detected at a 5 per cent false‐positive rate. However, inhibin‐A MOMs were strongly correlated with hCG MOMs in the cases (r=0.73, p<0.001) and the controls (r=0.56, p<0.001). This will diminish the value of adding inhibin‐A to the existing hCG and AFP screening protocol. Copyright © 1999 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>10360516</pmid><doi>10.1002/(SICI)1097-0223(199905)19:5<463::AID-PD574>3.0.CO;2-Q</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult alpha-Fetoproteins - analysis Asian Asian Continental Ancestry Group Biological and medical sciences Biomarkers - blood Case-Control Studies Chorionic Gonadotropin - blood Down syndrome Down Syndrome - blood Down Syndrome - diagnosis Down Syndrome - embryology Female Fetal Diseases - blood Fetal Diseases - diagnosis Gynecology. Andrology. Obstetrics Humans inhibin-A Inhibins - blood Management. Prenatal diagnosis Medical sciences Predictive Value of Tests Pregnancy Pregnancy Trimester, Second Pregnancy. Fetus. Placenta Prenatal Diagnosis screening |
| title | Second-trimester maternal serum inhibin-A screening for fetal Down syndrome in Asian women |
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