Early Arrest in B Cell Development in Transgenic Mice That Express the E41K Bruton's Tyrosine Kinase Mutant Under the Control of the CD19 Promoter Region

Bruton's tyrosine kinase (Btk) is a nonreceptor protein kinase that is defective in X-linked agammaglobulinemia in humans and in X-linked immunodeficiency in mice. To study the effect of Btk activation in early B cell development in vivo, we have created transgenic mouse strains expressing Btk...

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Veröffentlicht in:	The Journal of immunology (1950) 1999-06, Vol.162 (11), p.6526-6533
Hauptverfasser:	Maas, Alex, Dingjan, Gemma M, Grosveld, Frank, Hendriks, Rudolf W
Format:	Artikel
Sprache:	eng
Schlagworte:	Agammaglobulinemia - blood Agammaglobulinemia - genetics Animals Antigens, CD19 - genetics B-Lymphocyte Subsets - cytology B-Lymphocyte Subsets - enzymology B-Lymphocyte Subsets - pathology Cell Differentiation - genetics Cell Differentiation - immunology Gene Expression Regulation - immunology Glutamic Acid - genetics Humans Immunoglobulin G - biosynthesis Immunoglobulin G - blood Immunoglobulin M - biosynthesis Immunoglobulin M - blood Immunophenotyping Lymphopenia - genetics Lymphopenia - immunology Lymphopenia - pathology Lysine - genetics Mice Mice, Transgenic Plasma Cells - pathology Point Mutation - immunology Promoter Regions, Genetic - immunology Protein-Tyrosine Kinases - biosynthesis Protein-Tyrosine Kinases - genetics Spleen - cytology Spleen - immunology Spleen - pathology Transgenes - immunology
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