Minor Role of Cl– Secretion in Non-Cystic Fibrosis and Cystic Fibrosis Human Nasal Epithelium

Na + and Cl – currents were studied in primary cultures of human nasal epithelium derived from non-cystic fibrosis (non-CF) and cystic fibrosis (CF) patients. We found that Na + absorption dominates transepithelial transport and the Na + current contains an amiloride-sensitive and amiloride-insensit...

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Veröffentlicht in:	Cellular physiology and biochemistry 1999-01, Vol.9 (1), p.1-10
Hauptverfasser:	Rückes-Nilges, Claudia, Weber, Ulrike, Lindemann, Hermann, Münker, Gerd, Clauss, Wolfgang, Weber, Wolf-Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid - pharmacology Adenosine Triphosphate - pharmacology Amiloride - pharmacology Calcium Channel Blockers - pharmacology Cells, Cultured Chloride Channels - drug effects Chloride Channels - physiology Chlorides - metabolism Cyclic AMP - pharmacology Cystic Fibrosis - physiopathology Humans Membrane Potentials - physiology Nasal Mucosa - metabolism Nasal Mucosa - physiology Nasal Mucosa - physiopathology Nitrobenzoates - pharmacology Original Paper ortho-Aminobenzoates - pharmacology Reference Values Sodium - metabolism Sodium Channels - drug effects Sodium Channels - physiology
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