A Randomized, Controlled Trial of Nasal Phenylephrine in Infants Hospitalized for Bronchiolitis
Objective To examine the hypothesis that pharmacologic treatment of nasal obstruction, specifically alpha-adrenergic nose drops, will decrease objective signs of respiratory distress in infants with bronchiolitis. Study design Forty-one infants aged 3 weeks to 12 months hospitalized for viral bronch...
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| Veröffentlicht in: | The Journal of pediatrics 2008-12, Vol.153 (6), p.795-798.e1 |
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| container_title | The Journal of pediatrics |
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| creator | Ralston, Shawn, MD Roohi, Mahshid, RN |
| description | Objective To examine the hypothesis that pharmacologic treatment of nasal obstruction, specifically alpha-adrenergic nose drops, will decrease objective signs of respiratory distress in infants with bronchiolitis. Study design Forty-one infants aged 3 weeks to 12 months hospitalized for viral bronchiolitis were enrolled in this double-blinded, placebo-controlled trial of topical 0.5% phenylephrine drops. The primary outcome measure was change in oxygen saturation. Secondary outcomes were changes in respiratory scores and vital signs. Results There were no statistical differences in any of the outcome measures between groups. No adverse events were observed. Overall, participants showed an average 1.6 percentage point increase in their oxygen saturations ( P = .002) and a 0.5-point improvement in respiratory score ( P = .003) over the 30 minutes of the study. Conclusions Topical nasal phenylephrine did not produce significant short-term improvements in clinical status in infants hospitalized for acute bronchiolitis. |
| doi_str_mv | 10.1016/j.jpeds.2008.06.003 |
| format | Article |
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Study design Forty-one infants aged 3 weeks to 12 months hospitalized for viral bronchiolitis were enrolled in this double-blinded, placebo-controlled trial of topical 0.5% phenylephrine drops. The primary outcome measure was change in oxygen saturation. Secondary outcomes were changes in respiratory scores and vital signs. Results There were no statistical differences in any of the outcome measures between groups. No adverse events were observed. Overall, participants showed an average 1.6 percentage point increase in their oxygen saturations ( P = .002) and a 0.5-point improvement in respiratory score ( P = .003) over the 30 minutes of the study. Conclusions Topical nasal phenylephrine did not produce significant short-term improvements in clinical status in infants hospitalized for acute bronchiolitis.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/j.jpeds.2008.06.003</identifier><identifier>PMID: 18657831</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>Maryland Heights, MO: Mosby, Inc</publisher><subject>Biological and medical sciences ; Bronchiolitis, Viral - drug therapy ; Bronchiolitis, Viral - physiopathology ; Chronic obstructive pulmonary disease, asthma ; Double-Blind Method ; Female ; General aspects ; Hospitalization ; Humans ; Infant ; Infant, Newborn ; Male ; Medical sciences ; Nasal Decongestants - pharmacology ; Nasal Decongestants - therapeutic use ; New Mexico ; Oxygen Consumption - drug effects ; Pediatrics ; Phenylephrine - pharmacology ; Phenylephrine - therapeutic use ; Pneumology ; Respiration - drug effects</subject><ispartof>The Journal of pediatrics, 2008-12, Vol.153 (6), p.795-798.e1</ispartof><rights>Mosby, Inc.</rights><rights>2008 Mosby, Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-cde34636e013e037a0a6954fdd11ad9f08b975b8485f3e72c4ca61fd1308baf23</citedby><cites>FETCH-LOGICAL-c442t-cde34636e013e037a0a6954fdd11ad9f08b975b8485f3e72c4ca61fd1308baf23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpeds.2008.06.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3554,27933,27934,46004</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20946814$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18657831$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ralston, Shawn, MD</creatorcontrib><creatorcontrib>Roohi, Mahshid, RN</creatorcontrib><title>A Randomized, Controlled Trial of Nasal Phenylephrine in Infants Hospitalized for Bronchiolitis</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>Objective To examine the hypothesis that pharmacologic treatment of nasal obstruction, specifically alpha-adrenergic nose drops, will decrease objective signs of respiratory distress in infants with bronchiolitis. Study design Forty-one infants aged 3 weeks to 12 months hospitalized for viral bronchiolitis were enrolled in this double-blinded, placebo-controlled trial of topical 0.5% phenylephrine drops. The primary outcome measure was change in oxygen saturation. Secondary outcomes were changes in respiratory scores and vital signs. Results There were no statistical differences in any of the outcome measures between groups. No adverse events were observed. Overall, participants showed an average 1.6 percentage point increase in their oxygen saturations ( P = .002) and a 0.5-point improvement in respiratory score ( P = .003) over the 30 minutes of the study. Conclusions Topical nasal phenylephrine did not produce significant short-term improvements in clinical status in infants hospitalized for acute bronchiolitis.</description><subject>Biological and medical sciences</subject><subject>Bronchiolitis, Viral - drug therapy</subject><subject>Bronchiolitis, Viral - physiopathology</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>General aspects</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nasal Decongestants - pharmacology</subject><subject>Nasal Decongestants - therapeutic use</subject><subject>New Mexico</subject><subject>Oxygen Consumption - drug effects</subject><subject>Pediatrics</subject><subject>Phenylephrine - pharmacology</subject><subject>Phenylephrine - therapeutic use</subject><subject>Pneumology</subject><subject>Respiration - drug effects</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksGKFDEQhhtR3NnVJxAkFz1tt5VOJt19UFgHdRcWFV3PIZNUmLSZZDbpEcanN-0MCl48JZDvryq-VFU9o9BQoOLV2Iw7NLlpAfoGRAPAHlQLCkNXi56xh9UCoG1rxjtxVp3nPALAwAEeV2e0F8uuZ3RRySvyRQUTt-4nmkuyimFK0Xs05C455Um05KPK5fJ5g-HgcbdJLiBxgdwEq8KUyXXMOzcpPxcgNibyNsWgNy56N7n8pHpklc_49HReVN_ev7tbXde3nz7crK5ua815O9XaIOOCCQTKEFinQIlhya0xlCozWOjXQ7dc97xfWoZdq7lWglpDWXlRtmUX1ctj3V2K93vMk9y6rNF7FTDusxRDDy1teQHZEdQp5pzQyl1yW5UOkoKcvcpR_vYqZ68ShCxeS-r5qfx-vUXzN3MSWYAXJ0BlrbxNKmiX_3BtMS96Ord_feSwyPjhMMmsHQaNxiXUkzTR_WeQN__ktXfBlZbf8YB5jPsUimdJZW4lyK_zCswbAD0AL7_PfgFnLqxl</recordid><startdate>20081201</startdate><enddate>20081201</enddate><creator>Ralston, Shawn, MD</creator><creator>Roohi, Mahshid, RN</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20081201</creationdate><title>A Randomized, Controlled Trial of Nasal Phenylephrine in Infants Hospitalized for Bronchiolitis</title><author>Ralston, Shawn, MD ; Roohi, Mahshid, RN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-cde34636e013e037a0a6954fdd11ad9f08b975b8485f3e72c4ca61fd1308baf23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biological and medical sciences</topic><topic>Bronchiolitis, Viral - drug therapy</topic><topic>Bronchiolitis, Viral - physiopathology</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>General aspects</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nasal Decongestants - pharmacology</topic><topic>Nasal Decongestants - therapeutic use</topic><topic>New Mexico</topic><topic>Oxygen Consumption - drug effects</topic><topic>Pediatrics</topic><topic>Phenylephrine - pharmacology</topic><topic>Phenylephrine - therapeutic use</topic><topic>Pneumology</topic><topic>Respiration - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ralston, Shawn, MD</creatorcontrib><creatorcontrib>Roohi, Mahshid, RN</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ralston, Shawn, MD</au><au>Roohi, Mahshid, RN</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Randomized, Controlled Trial of Nasal Phenylephrine in Infants Hospitalized for Bronchiolitis</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>2008-12-01</date><risdate>2008</risdate><volume>153</volume><issue>6</issue><spage>795</spage><epage>798.e1</epage><pages>795-798.e1</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>Objective To examine the hypothesis that pharmacologic treatment of nasal obstruction, specifically alpha-adrenergic nose drops, will decrease objective signs of respiratory distress in infants with bronchiolitis. 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| subjects | Biological and medical sciences Bronchiolitis, Viral - drug therapy Bronchiolitis, Viral - physiopathology Chronic obstructive pulmonary disease, asthma Double-Blind Method Female General aspects Hospitalization Humans Infant Infant, Newborn Male Medical sciences Nasal Decongestants - pharmacology Nasal Decongestants - therapeutic use New Mexico Oxygen Consumption - drug effects Pediatrics Phenylephrine - pharmacology Phenylephrine - therapeutic use Pneumology Respiration - drug effects |
| title | A Randomized, Controlled Trial of Nasal Phenylephrine in Infants Hospitalized for Bronchiolitis |
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