Neuroblastoma regression and immunity induced by transgenic expression of interleukin-12

Purpose: Interleukin-12 (IL-12) is a cytokine with potent antitumor effects. The authors sought to assess its capacity to increase tumor immunogenicity when expressed by tumor cells in a murine model of neuroblastoma. Methods: Syngeneic A/J mice were inoculated subcutaneously with 2 × 106 cells from...

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