Angiotensin receptor blockers are superior to angiotensin-converting enzyme inhibitors in the suppression of hepatic fibrosis in a bile duct-ligated rat model
Background Angiotensin blockade such as with an angiotensin II receptor blocker (ARB) or angiotensinconverting enzyme inhibitor (ACEI) has antifibrotic properties. The aim of this study was to evaluate and compare the antifibrotic effect between ARBs and ACEIs. Methods Common bile duct-ligated (BDL)...
Gespeichert in:
| Veröffentlicht in: | Journal of gastroenterology 2008-11, Vol.43 (11), p.889-896 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 896 |
|---|---|
| container_issue | 11 |
| container_start_page | 889 |
| container_title | Journal of gastroenterology |
| container_volume | 43 |
| creator | Kim, Moon Young Baik, Soon Koo Park, Dong Hun Jang, Yoon Ok Suk, Ki Tae Yea, Chang Jin Lee, Il Young Kim, Jae Woo Kim, Hyun Soo Kwon, Sang Ok Cho, Mi Yun Ko, Sang Baik Chang, Sei Jin Um, Soon Ho Han, Kwang-Hyub |
| description | Background Angiotensin blockade such as with an angiotensin II receptor blocker (ARB) or angiotensinconverting enzyme inhibitor (ACEI) has antifibrotic properties. The aim of this study was to evaluate and compare the antifibrotic effect between ARBs and ACEIs. Methods Common bile duct-ligated (BDL) adult Sprague-Dawley rats were allocated to five groups (each group, n = 8) as follows: G1, BDL without drug; G2, BDL + captopril 100 mg/kg per day; G3, BDL + ramipril 10 mg/kg per day; G4, BDL + losartan 10 mg/kg per day; G5, BDL + irbesartan 15 mg/kg per day. Four weeks post-BDL, hepatic fibrosis was analyzed histomorphologically using Batts and Ludwig scores. α-Smooth muscle actin (α-SMA) expression by immunohistochemical staining, hydroxyproline contents of liver tissue by spectrophotometry, and angiotensin receptor, collagen, procollagen, and transforming growth factor β (TGF-β) expressions were evaluated by real-time reverse transcriptase-polymerase chain reaction. Angiotensin receptor expression was also determined by Western blotting. Results Batts and Ludwig scores were 3.8, 2.6, 2.4, 1.8, and 1.6 in G1, G2, G3, G4, and G5, respectively. Histologically, ARB groups (G4, G5) showed significant suppression of hepatic fibrosis compared with ACEI groups or the control. Expressions of α-SMA (%) and the content of hydroxyproline (μg liver tissue) were significantly lower in ARB groups (G4, G5) than in ACEI groups (G2, G3) (P < 0.05). Also, ARB reduced the expression of angiotensin receptor, collagen, procollagen, and TGF-β1 compared with ACEI. Western blot analysis showed that the expression of angiotensin receptor was inhibited in both ARB and ACEI groups. Conclusions Both ARB and ACEI attenuate hepatic fibrosis through inhibiting hepatic stellate cell activation, and the inhibitory effect of ARBs on hepatic fibrosis is superior to that of ACEIs in the BDL rat model. |
| doi_str_mv | 10.1007/s00535-008-2239-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69800339</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69800339</sourcerecordid><originalsourceid>FETCH-LOGICAL-c512t-7286e7f4936e56175f66da99cf634e186442520df31e89cf812fe21cc5ee9c773</originalsourceid><addsrcrecordid>eNp9ks2O1SAcxYnRONfRB3CjxIW7Kp9tWU4mfiWTuNBZE0r_9DL2QgVqMj6Mzyp3epObuHAD5PA7B8gBoZeUvKOEdO8zIZLLhpC-YYyrRj1COyqqIhVjj9GOKCEaSjtxgZ7lfEcI5UT2T9EFVYQyIvgO_bkKk48FQvYBJ7CwlJjwMEf7A1LGJgHO6wLJV7VEbM50Y2P4Ban4MGEIv-8PgH3Y-8HXgFyXuOwfvEuCnH0MODq8h8UUb7HzQ4rZP2AGD34GPK62NLOfTIERJ1PwIY4wP0dPnJkzvDjNl-j244fv15-bm6-fvlxf3TRWUlaajvUtdE4o3oJsaSdd245GKetaLoD2rRBMMjI6TqGvak-ZA0atlQDKdh2_RG-33CXFnyvkog8-W5hnEyCuWbeqJ4RzVcE3_4B3cU2h3k0z2lEplKAVohtk6ytzAqeX5A8m3WtK9LE5vTWna3P62Jw-Br86Ba_DAcaz41RVBdgG5LoVJkjnk_-X-nozORO1mZLP-vYbO_4DKts6KP4X0eGv0w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>217154941</pqid></control><display><type>article</type><title>Angiotensin receptor blockers are superior to angiotensin-converting enzyme inhibitors in the suppression of hepatic fibrosis in a bile duct-ligated rat model</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Kim, Moon Young ; Baik, Soon Koo ; Park, Dong Hun ; Jang, Yoon Ok ; Suk, Ki Tae ; Yea, Chang Jin ; Lee, Il Young ; Kim, Jae Woo ; Kim, Hyun Soo ; Kwon, Sang Ok ; Cho, Mi Yun ; Ko, Sang Baik ; Chang, Sei Jin ; Um, Soon Ho ; Han, Kwang-Hyub</creator><creatorcontrib>Kim, Moon Young ; Baik, Soon Koo ; Park, Dong Hun ; Jang, Yoon Ok ; Suk, Ki Tae ; Yea, Chang Jin ; Lee, Il Young ; Kim, Jae Woo ; Kim, Hyun Soo ; Kwon, Sang Ok ; Cho, Mi Yun ; Ko, Sang Baik ; Chang, Sei Jin ; Um, Soon Ho ; Han, Kwang-Hyub</creatorcontrib><description>Background Angiotensin blockade such as with an angiotensin II receptor blocker (ARB) or angiotensinconverting enzyme inhibitor (ACEI) has antifibrotic properties. The aim of this study was to evaluate and compare the antifibrotic effect between ARBs and ACEIs. Methods Common bile duct-ligated (BDL) adult Sprague-Dawley rats were allocated to five groups (each group, n = 8) as follows: G1, BDL without drug; G2, BDL + captopril 100 mg/kg per day; G3, BDL + ramipril 10 mg/kg per day; G4, BDL + losartan 10 mg/kg per day; G5, BDL + irbesartan 15 mg/kg per day. Four weeks post-BDL, hepatic fibrosis was analyzed histomorphologically using Batts and Ludwig scores. α-Smooth muscle actin (α-SMA) expression by immunohistochemical staining, hydroxyproline contents of liver tissue by spectrophotometry, and angiotensin receptor, collagen, procollagen, and transforming growth factor β (TGF-β) expressions were evaluated by real-time reverse transcriptase-polymerase chain reaction. Angiotensin receptor expression was also determined by Western blotting. Results Batts and Ludwig scores were 3.8, 2.6, 2.4, 1.8, and 1.6 in G1, G2, G3, G4, and G5, respectively. Histologically, ARB groups (G4, G5) showed significant suppression of hepatic fibrosis compared with ACEI groups or the control. Expressions of α-SMA (%) and the content of hydroxyproline (μg liver tissue) were significantly lower in ARB groups (G4, G5) than in ACEI groups (G2, G3) (P < 0.05). Also, ARB reduced the expression of angiotensin receptor, collagen, procollagen, and TGF-β1 compared with ACEI. Western blot analysis showed that the expression of angiotensin receptor was inhibited in both ARB and ACEI groups. Conclusions Both ARB and ACEI attenuate hepatic fibrosis through inhibiting hepatic stellate cell activation, and the inhibitory effect of ARBs on hepatic fibrosis is superior to that of ACEIs in the BDL rat model.</description><identifier>ISSN: 0944-1174</identifier><identifier>EISSN: 1435-5922</identifier><identifier>DOI: 10.1007/s00535-008-2239-9</identifier><identifier>PMID: 19012043</identifier><language>eng</language><publisher>Japan: Japan : Springer Japan</publisher><subject>Abdominal Surgery ; angiotensin converting enzyme inhibitor ; angiotensin II receptor blocker ; Angiotensin II Type 1 Receptor Blockers - therapeutic use ; Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors - therapeutic use ; Animals ; Biliary Tract ; Blotting, Western ; Colorectal Surgery ; Common Bile Duct - surgery ; Disease Progression ; Gastroenterology ; Gene Expression Regulation ; hepatic fibrosis ; hepatic stellate cell ; Hepatology ; Hydroxyproline - metabolism ; Immunohistochemistry ; Ligation ; Liver ; Liver Cirrhosis, Experimental - drug therapy ; Liver Cirrhosis, Experimental - enzymology ; Liver Cirrhosis, Experimental - pathology ; Male ; Medicine ; Medicine & Public Health ; Pancreas ; Peptidyl-Dipeptidase A - biosynthesis ; Peptidyl-Dipeptidase A - drug effects ; Peptidyl-Dipeptidase A - genetics ; Rats ; Rats, Sprague-Dawley ; Receptors, Angiotensin - biosynthesis ; Receptors, Angiotensin - genetics ; Reverse Transcriptase Polymerase Chain Reaction ; RNA - genetics ; Spectrophotometry ; Surgical Oncology</subject><ispartof>Journal of gastroenterology, 2008-11, Vol.43 (11), p.889-896</ispartof><rights>Springer Japan 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-7286e7f4936e56175f66da99cf634e186442520df31e89cf812fe21cc5ee9c773</citedby><cites>FETCH-LOGICAL-c512t-7286e7f4936e56175f66da99cf634e186442520df31e89cf812fe21cc5ee9c773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00535-008-2239-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00535-008-2239-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19012043$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Moon Young</creatorcontrib><creatorcontrib>Baik, Soon Koo</creatorcontrib><creatorcontrib>Park, Dong Hun</creatorcontrib><creatorcontrib>Jang, Yoon Ok</creatorcontrib><creatorcontrib>Suk, Ki Tae</creatorcontrib><creatorcontrib>Yea, Chang Jin</creatorcontrib><creatorcontrib>Lee, Il Young</creatorcontrib><creatorcontrib>Kim, Jae Woo</creatorcontrib><creatorcontrib>Kim, Hyun Soo</creatorcontrib><creatorcontrib>Kwon, Sang Ok</creatorcontrib><creatorcontrib>Cho, Mi Yun</creatorcontrib><creatorcontrib>Ko, Sang Baik</creatorcontrib><creatorcontrib>Chang, Sei Jin</creatorcontrib><creatorcontrib>Um, Soon Ho</creatorcontrib><creatorcontrib>Han, Kwang-Hyub</creatorcontrib><title>Angiotensin receptor blockers are superior to angiotensin-converting enzyme inhibitors in the suppression of hepatic fibrosis in a bile duct-ligated rat model</title><title>Journal of gastroenterology</title><addtitle>J Gastroenterol</addtitle><addtitle>J Gastroenterol</addtitle><description>Background Angiotensin blockade such as with an angiotensin II receptor blocker (ARB) or angiotensinconverting enzyme inhibitor (ACEI) has antifibrotic properties. The aim of this study was to evaluate and compare the antifibrotic effect between ARBs and ACEIs. Methods Common bile duct-ligated (BDL) adult Sprague-Dawley rats were allocated to five groups (each group, n = 8) as follows: G1, BDL without drug; G2, BDL + captopril 100 mg/kg per day; G3, BDL + ramipril 10 mg/kg per day; G4, BDL + losartan 10 mg/kg per day; G5, BDL + irbesartan 15 mg/kg per day. Four weeks post-BDL, hepatic fibrosis was analyzed histomorphologically using Batts and Ludwig scores. α-Smooth muscle actin (α-SMA) expression by immunohistochemical staining, hydroxyproline contents of liver tissue by spectrophotometry, and angiotensin receptor, collagen, procollagen, and transforming growth factor β (TGF-β) expressions were evaluated by real-time reverse transcriptase-polymerase chain reaction. Angiotensin receptor expression was also determined by Western blotting. Results Batts and Ludwig scores were 3.8, 2.6, 2.4, 1.8, and 1.6 in G1, G2, G3, G4, and G5, respectively. Histologically, ARB groups (G4, G5) showed significant suppression of hepatic fibrosis compared with ACEI groups or the control. Expressions of α-SMA (%) and the content of hydroxyproline (μg liver tissue) were significantly lower in ARB groups (G4, G5) than in ACEI groups (G2, G3) (P < 0.05). Also, ARB reduced the expression of angiotensin receptor, collagen, procollagen, and TGF-β1 compared with ACEI. Western blot analysis showed that the expression of angiotensin receptor was inhibited in both ARB and ACEI groups. Conclusions Both ARB and ACEI attenuate hepatic fibrosis through inhibiting hepatic stellate cell activation, and the inhibitory effect of ARBs on hepatic fibrosis is superior to that of ACEIs in the BDL rat model.</description><subject>Abdominal Surgery</subject><subject>angiotensin converting enzyme inhibitor</subject><subject>angiotensin II receptor blocker</subject><subject>Angiotensin II Type 1 Receptor Blockers - therapeutic use</subject><subject>Angiotensin Receptor Antagonists</subject><subject>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</subject><subject>Animals</subject><subject>Biliary Tract</subject><subject>Blotting, Western</subject><subject>Colorectal Surgery</subject><subject>Common Bile Duct - surgery</subject><subject>Disease Progression</subject><subject>Gastroenterology</subject><subject>Gene Expression Regulation</subject><subject>hepatic fibrosis</subject><subject>hepatic stellate cell</subject><subject>Hepatology</subject><subject>Hydroxyproline - metabolism</subject><subject>Immunohistochemistry</subject><subject>Ligation</subject><subject>Liver</subject><subject>Liver Cirrhosis, Experimental - drug therapy</subject><subject>Liver Cirrhosis, Experimental - enzymology</subject><subject>Liver Cirrhosis, Experimental - pathology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Pancreas</subject><subject>Peptidyl-Dipeptidase A - biosynthesis</subject><subject>Peptidyl-Dipeptidase A - drug effects</subject><subject>Peptidyl-Dipeptidase A - genetics</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Angiotensin - biosynthesis</subject><subject>Receptors, Angiotensin - genetics</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA - genetics</subject><subject>Spectrophotometry</subject><subject>Surgical Oncology</subject><issn>0944-1174</issn><issn>1435-5922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9ks2O1SAcxYnRONfRB3CjxIW7Kp9tWU4mfiWTuNBZE0r_9DL2QgVqMj6Mzyp3epObuHAD5PA7B8gBoZeUvKOEdO8zIZLLhpC-YYyrRj1COyqqIhVjj9GOKCEaSjtxgZ7lfEcI5UT2T9EFVYQyIvgO_bkKk48FQvYBJ7CwlJjwMEf7A1LGJgHO6wLJV7VEbM50Y2P4Ban4MGEIv-8PgH3Y-8HXgFyXuOwfvEuCnH0MODq8h8UUb7HzQ4rZP2AGD34GPK62NLOfTIERJ1PwIY4wP0dPnJkzvDjNl-j244fv15-bm6-fvlxf3TRWUlaajvUtdE4o3oJsaSdd245GKetaLoD2rRBMMjI6TqGvak-ZA0atlQDKdh2_RG-33CXFnyvkog8-W5hnEyCuWbeqJ4RzVcE3_4B3cU2h3k0z2lEplKAVohtk6ytzAqeX5A8m3WtK9LE5vTWna3P62Jw-Br86Ba_DAcaz41RVBdgG5LoVJkjnk_-X-nozORO1mZLP-vYbO_4DKts6KP4X0eGv0w</recordid><startdate>20081101</startdate><enddate>20081101</enddate><creator>Kim, Moon Young</creator><creator>Baik, Soon Koo</creator><creator>Park, Dong Hun</creator><creator>Jang, Yoon Ok</creator><creator>Suk, Ki Tae</creator><creator>Yea, Chang Jin</creator><creator>Lee, Il Young</creator><creator>Kim, Jae Woo</creator><creator>Kim, Hyun Soo</creator><creator>Kwon, Sang Ok</creator><creator>Cho, Mi Yun</creator><creator>Ko, Sang Baik</creator><creator>Chang, Sei Jin</creator><creator>Um, Soon Ho</creator><creator>Han, Kwang-Hyub</creator><general>Japan : Springer Japan</general><general>Springer Japan</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>20081101</creationdate><title>Angiotensin receptor blockers are superior to angiotensin-converting enzyme inhibitors in the suppression of hepatic fibrosis in a bile duct-ligated rat model</title><author>Kim, Moon Young ; Baik, Soon Koo ; Park, Dong Hun ; Jang, Yoon Ok ; Suk, Ki Tae ; Yea, Chang Jin ; Lee, Il Young ; Kim, Jae Woo ; Kim, Hyun Soo ; Kwon, Sang Ok ; Cho, Mi Yun ; Ko, Sang Baik ; Chang, Sei Jin ; Um, Soon Ho ; Han, Kwang-Hyub</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-7286e7f4936e56175f66da99cf634e186442520df31e89cf812fe21cc5ee9c773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Abdominal Surgery</topic><topic>angiotensin converting enzyme inhibitor</topic><topic>angiotensin II receptor blocker</topic><topic>Angiotensin II Type 1 Receptor Blockers - therapeutic use</topic><topic>Angiotensin Receptor Antagonists</topic><topic>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</topic><topic>Animals</topic><topic>Biliary Tract</topic><topic>Blotting, Western</topic><topic>Colorectal Surgery</topic><topic>Common Bile Duct - surgery</topic><topic>Disease Progression</topic><topic>Gastroenterology</topic><topic>Gene Expression Regulation</topic><topic>hepatic fibrosis</topic><topic>hepatic stellate cell</topic><topic>Hepatology</topic><topic>Hydroxyproline - metabolism</topic><topic>Immunohistochemistry</topic><topic>Ligation</topic><topic>Liver</topic><topic>Liver Cirrhosis, Experimental - drug therapy</topic><topic>Liver Cirrhosis, Experimental - enzymology</topic><topic>Liver Cirrhosis, Experimental - pathology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Pancreas</topic><topic>Peptidyl-Dipeptidase A - biosynthesis</topic><topic>Peptidyl-Dipeptidase A - drug effects</topic><topic>Peptidyl-Dipeptidase A - genetics</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Angiotensin - biosynthesis</topic><topic>Receptors, Angiotensin - genetics</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA - genetics</topic><topic>Spectrophotometry</topic><topic>Surgical Oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Moon Young</creatorcontrib><creatorcontrib>Baik, Soon Koo</creatorcontrib><creatorcontrib>Park, Dong Hun</creatorcontrib><creatorcontrib>Jang, Yoon Ok</creatorcontrib><creatorcontrib>Suk, Ki Tae</creatorcontrib><creatorcontrib>Yea, Chang Jin</creatorcontrib><creatorcontrib>Lee, Il Young</creatorcontrib><creatorcontrib>Kim, Jae Woo</creatorcontrib><creatorcontrib>Kim, Hyun Soo</creatorcontrib><creatorcontrib>Kwon, Sang Ok</creatorcontrib><creatorcontrib>Cho, Mi Yun</creatorcontrib><creatorcontrib>Ko, Sang Baik</creatorcontrib><creatorcontrib>Chang, Sei Jin</creatorcontrib><creatorcontrib>Um, Soon Ho</creatorcontrib><creatorcontrib>Han, Kwang-Hyub</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Moon Young</au><au>Baik, Soon Koo</au><au>Park, Dong Hun</au><au>Jang, Yoon Ok</au><au>Suk, Ki Tae</au><au>Yea, Chang Jin</au><au>Lee, Il Young</au><au>Kim, Jae Woo</au><au>Kim, Hyun Soo</au><au>Kwon, Sang Ok</au><au>Cho, Mi Yun</au><au>Ko, Sang Baik</au><au>Chang, Sei Jin</au><au>Um, Soon Ho</au><au>Han, Kwang-Hyub</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Angiotensin receptor blockers are superior to angiotensin-converting enzyme inhibitors in the suppression of hepatic fibrosis in a bile duct-ligated rat model</atitle><jtitle>Journal of gastroenterology</jtitle><stitle>J Gastroenterol</stitle><addtitle>J Gastroenterol</addtitle><date>2008-11-01</date><risdate>2008</risdate><volume>43</volume><issue>11</issue><spage>889</spage><epage>896</epage><pages>889-896</pages><issn>0944-1174</issn><eissn>1435-5922</eissn><abstract>Background Angiotensin blockade such as with an angiotensin II receptor blocker (ARB) or angiotensinconverting enzyme inhibitor (ACEI) has antifibrotic properties. The aim of this study was to evaluate and compare the antifibrotic effect between ARBs and ACEIs. Methods Common bile duct-ligated (BDL) adult Sprague-Dawley rats were allocated to five groups (each group, n = 8) as follows: G1, BDL without drug; G2, BDL + captopril 100 mg/kg per day; G3, BDL + ramipril 10 mg/kg per day; G4, BDL + losartan 10 mg/kg per day; G5, BDL + irbesartan 15 mg/kg per day. Four weeks post-BDL, hepatic fibrosis was analyzed histomorphologically using Batts and Ludwig scores. α-Smooth muscle actin (α-SMA) expression by immunohistochemical staining, hydroxyproline contents of liver tissue by spectrophotometry, and angiotensin receptor, collagen, procollagen, and transforming growth factor β (TGF-β) expressions were evaluated by real-time reverse transcriptase-polymerase chain reaction. Angiotensin receptor expression was also determined by Western blotting. Results Batts and Ludwig scores were 3.8, 2.6, 2.4, 1.8, and 1.6 in G1, G2, G3, G4, and G5, respectively. Histologically, ARB groups (G4, G5) showed significant suppression of hepatic fibrosis compared with ACEI groups or the control. Expressions of α-SMA (%) and the content of hydroxyproline (μg liver tissue) were significantly lower in ARB groups (G4, G5) than in ACEI groups (G2, G3) (P < 0.05). Also, ARB reduced the expression of angiotensin receptor, collagen, procollagen, and TGF-β1 compared with ACEI. Western blot analysis showed that the expression of angiotensin receptor was inhibited in both ARB and ACEI groups. Conclusions Both ARB and ACEI attenuate hepatic fibrosis through inhibiting hepatic stellate cell activation, and the inhibitory effect of ARBs on hepatic fibrosis is superior to that of ACEIs in the BDL rat model.</abstract><cop>Japan</cop><pub>Japan : Springer Japan</pub><pmid>19012043</pmid><doi>10.1007/s00535-008-2239-9</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0944-1174 |
| ispartof | Journal of gastroenterology, 2008-11, Vol.43 (11), p.889-896 |
| issn | 0944-1174 1435-5922 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69800339 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Abdominal Surgery angiotensin converting enzyme inhibitor angiotensin II receptor blocker Angiotensin II Type 1 Receptor Blockers - therapeutic use Angiotensin Receptor Antagonists Angiotensin-Converting Enzyme Inhibitors - therapeutic use Animals Biliary Tract Blotting, Western Colorectal Surgery Common Bile Duct - surgery Disease Progression Gastroenterology Gene Expression Regulation hepatic fibrosis hepatic stellate cell Hepatology Hydroxyproline - metabolism Immunohistochemistry Ligation Liver Liver Cirrhosis, Experimental - drug therapy Liver Cirrhosis, Experimental - enzymology Liver Cirrhosis, Experimental - pathology Male Medicine Medicine & Public Health Pancreas Peptidyl-Dipeptidase A - biosynthesis Peptidyl-Dipeptidase A - drug effects Peptidyl-Dipeptidase A - genetics Rats Rats, Sprague-Dawley Receptors, Angiotensin - biosynthesis Receptors, Angiotensin - genetics Reverse Transcriptase Polymerase Chain Reaction RNA - genetics Spectrophotometry Surgical Oncology |
| title | Angiotensin receptor blockers are superior to angiotensin-converting enzyme inhibitors in the suppression of hepatic fibrosis in a bile duct-ligated rat model |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T17%3A15%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Angiotensin%20receptor%20blockers%20are%20superior%20to%20angiotensin-converting%20enzyme%20inhibitors%20in%20the%20suppression%20of%20hepatic%20fibrosis%20in%20a%20bile%20duct-ligated%20rat%20model&rft.jtitle=Journal%20of%20gastroenterology&rft.au=Kim,%20Moon%20Young&rft.date=2008-11-01&rft.volume=43&rft.issue=11&rft.spage=889&rft.epage=896&rft.pages=889-896&rft.issn=0944-1174&rft.eissn=1435-5922&rft_id=info:doi/10.1007/s00535-008-2239-9&rft_dat=%3Cproquest_cross%3E69800339%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=217154941&rft_id=info:pmid/19012043&rfr_iscdi=true |