Effect of oral contraceptives on vascular endothelial growth factor, Cox-2 and aromatase expression in the endometrium of uteri affected by myomas and associated pathologies
Abstract Background The study was conducted to evaluate vascular endothelial growth factor (VEGF), Cox-2 and aromatase expression in the endometrium of uteri with myomas and other associated pathologies. Study Design Hysteroscopy was performed in 118 women of reproductive age with myomas and menorrh...
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| Veröffentlicht in: | Contraception (Stoneham) 2008-12, Vol.78 (6), p.479-485 |
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| creator | Maia, Hugo Casoy, Julio Pimentel, Kleber Correia, Tania Athayde, Célia Cruz, Thomaz Coutinho, Elsimar Metzker |
| description | Abstract Background The study was conducted to evaluate vascular endothelial growth factor (VEGF), Cox-2 and aromatase expression in the endometrium of uteri with myomas and other associated pathologies. Study Design Hysteroscopy was performed in 118 women of reproductive age with myomas and menorrhagia, 40 of whom were using a pill containing 75 mcg gestodene+30 mcg ethinylestradiol. Aromatase p450, VEGF and Cox-2 expression was detected using immunohistochemistry. Fisher's Exact Test and the Mann–Whitney test were used in the statistical analysis, with significance established at p |
| doi_str_mv | 10.1016/j.contraception.2008.07.002 |
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Study Design Hysteroscopy was performed in 118 women of reproductive age with myomas and menorrhagia, 40 of whom were using a pill containing 75 mcg gestodene+30 mcg ethinylestradiol. Aromatase p450, VEGF and Cox-2 expression was detected using immunohistochemistry. Fisher's Exact Test and the Mann–Whitney test were used in the statistical analysis, with significance established at p<.05. Results In patients with myomas and menorrhagia, associated pathologies such as adenomyosis, endometrial polyps and endometriosis were found in 32%, 12% and 17% of cases, respectively. Aromatase, Cox-2 and VEGF expression was greater during the proliferative phase compared to the luteal phase of the cycle or following oral contraceptive use. Conclusion Endogenous progesterone or combined oral contraceptives are potent inhibitors of VEGF, aromatase and Cox-2 expression in the endometrium of patients with myomas and menorrhagia.</description><identifier>ISSN: 0010-7824</identifier><identifier>EISSN: 1879-0518</identifier><identifier>DOI: 10.1016/j.contraception.2008.07.002</identifier><identifier>PMID: 19014794</identifier><identifier>CODEN: CCPTAY</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aromatase ; Aromatase - metabolism ; Biological and medical sciences ; Birth control ; Contraceptives, Oral - pharmacology ; Cox-2 ; Cyclooxygenase 2 - metabolism ; Endometrium - enzymology ; Endometrium - metabolism ; Endometrium - pathology ; Female ; Genital system. Reproduction ; Gestodene ; Gynecology. Andrology. Obstetrics ; Hormonal contraception ; Humans ; Hysterectomy ; Immunohistochemistry ; Luteal Phase ; Medical sciences ; Menorrhagia ; Menorrhagia - complications ; Menorrhagia - enzymology ; Menorrhagia - pathology ; Myoma ; Obstetrics and Gynecology ; Pharmacology. Drug treatments ; Progesterone - pharmacology ; Uterine Neoplasms - complications ; Uterine Neoplasms - enzymology ; Uterine Neoplasms - pathology ; Vascular Endothelial Growth Factor A - metabolism ; VEGF</subject><ispartof>Contraception (Stoneham), 2008-12, Vol.78 (6), p.479-485</ispartof><rights>Elsevier Inc.</rights><rights>2008 Elsevier Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-bf33ede0af135ab3e96eb251b20b0d37188d07f66a6495584fab433ffbf120a53</citedby><cites>FETCH-LOGICAL-c491t-bf33ede0af135ab3e96eb251b20b0d37188d07f66a6495584fab433ffbf120a53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.contraception.2008.07.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20938872$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19014794$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maia, Hugo</creatorcontrib><creatorcontrib>Casoy, Julio</creatorcontrib><creatorcontrib>Pimentel, Kleber</creatorcontrib><creatorcontrib>Correia, Tania</creatorcontrib><creatorcontrib>Athayde, Célia</creatorcontrib><creatorcontrib>Cruz, Thomaz</creatorcontrib><creatorcontrib>Coutinho, Elsimar Metzker</creatorcontrib><title>Effect of oral contraceptives on vascular endothelial growth factor, Cox-2 and aromatase expression in the endometrium of uteri affected by myomas and associated pathologies</title><title>Contraception (Stoneham)</title><addtitle>Contraception</addtitle><description>Abstract Background The study was conducted to evaluate vascular endothelial growth factor (VEGF), Cox-2 and aromatase expression in the endometrium of uteri with myomas and other associated pathologies. Study Design Hysteroscopy was performed in 118 women of reproductive age with myomas and menorrhagia, 40 of whom were using a pill containing 75 mcg gestodene+30 mcg ethinylestradiol. Aromatase p450, VEGF and Cox-2 expression was detected using immunohistochemistry. Fisher's Exact Test and the Mann–Whitney test were used in the statistical analysis, with significance established at p<.05. Results In patients with myomas and menorrhagia, associated pathologies such as adenomyosis, endometrial polyps and endometriosis were found in 32%, 12% and 17% of cases, respectively. Aromatase, Cox-2 and VEGF expression was greater during the proliferative phase compared to the luteal phase of the cycle or following oral contraceptive use. Conclusion Endogenous progesterone or combined oral contraceptives are potent inhibitors of VEGF, aromatase and Cox-2 expression in the endometrium of patients with myomas and menorrhagia.</description><subject>Adult</subject><subject>Aromatase</subject><subject>Aromatase - metabolism</subject><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>Contraceptives, Oral - pharmacology</subject><subject>Cox-2</subject><subject>Cyclooxygenase 2 - metabolism</subject><subject>Endometrium - enzymology</subject><subject>Endometrium - metabolism</subject><subject>Endometrium - pathology</subject><subject>Female</subject><subject>Genital system. Reproduction</subject><subject>Gestodene</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hormonal contraception</subject><subject>Humans</subject><subject>Hysterectomy</subject><subject>Immunohistochemistry</subject><subject>Luteal Phase</subject><subject>Medical sciences</subject><subject>Menorrhagia</subject><subject>Menorrhagia - complications</subject><subject>Menorrhagia - enzymology</subject><subject>Menorrhagia - pathology</subject><subject>Myoma</subject><subject>Obstetrics and Gynecology</subject><subject>Pharmacology. Drug treatments</subject><subject>Progesterone - pharmacology</subject><subject>Uterine Neoplasms - complications</subject><subject>Uterine Neoplasms - enzymology</subject><subject>Uterine Neoplasms - pathology</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><subject>VEGF</subject><issn>0010-7824</issn><issn>1879-0518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkkuP0zAUhSMEYsrAX0CWEKxIuc7LtpBGQlV5SCOxANaW41xPXZI42E6Z_ij-I8604rVi5YW_c-7VOTfLnlFYU6DNq_1auzF6pXGK1o3rAoCvga0BinvZinImcqgpv5-tACjkjBfVRfYohD0AMFGzh9kFFUArJqpV9mNrDOpInCHOq578YX3AQNxIDirouVee4Ni5uMPeJuzGu-9xR4zS0fmXZONu84KosSPKu0FFFZDg7eQxhLQhsSNJwjuDAaO387DMmyN6S9TdfOxIeyTDMYnDyScEp61aPiYVd653NxbD4-yBUX3AJ-f3Mvvydvt58z6__vjuw-bNda4rQWPemrLEDkEZWtaqLVE02BY1bQtooSsZ5bwDZppGNZWoa14Z1VZlaUxraAGqLi-zFyffybtvM4YoBxs09r0a0c1BNoIJUQMk8PUJ1N6F4NHIydtB-aOkIJe25F7-1ZZc2pLAZGorqZ-ex8ztgN1v7bmeBDw_A6kE1RuvRm3DL64AUXLOFqPticMUysGil0FbHDV21qd0Zefsfy509Y-P7u1o0-iveMSwd7MfU-6SylBIkJ-WA1vuC3jKoql4-ROvotS3</recordid><startdate>20081201</startdate><enddate>20081201</enddate><creator>Maia, Hugo</creator><creator>Casoy, Julio</creator><creator>Pimentel, Kleber</creator><creator>Correia, Tania</creator><creator>Athayde, Célia</creator><creator>Cruz, Thomaz</creator><creator>Coutinho, Elsimar Metzker</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20081201</creationdate><title>Effect of oral contraceptives on vascular endothelial growth factor, Cox-2 and aromatase expression in the endometrium of uteri affected by myomas and associated pathologies</title><author>Maia, Hugo ; Casoy, Julio ; Pimentel, Kleber ; Correia, Tania ; Athayde, Célia ; Cruz, Thomaz ; Coutinho, Elsimar Metzker</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-bf33ede0af135ab3e96eb251b20b0d37188d07f66a6495584fab433ffbf120a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aromatase</topic><topic>Aromatase - metabolism</topic><topic>Biological and medical sciences</topic><topic>Birth control</topic><topic>Contraceptives, Oral - pharmacology</topic><topic>Cox-2</topic><topic>Cyclooxygenase 2 - metabolism</topic><topic>Endometrium - enzymology</topic><topic>Endometrium - metabolism</topic><topic>Endometrium - pathology</topic><topic>Female</topic><topic>Genital system. Reproduction</topic><topic>Gestodene</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hormonal contraception</topic><topic>Humans</topic><topic>Hysterectomy</topic><topic>Immunohistochemistry</topic><topic>Luteal Phase</topic><topic>Medical sciences</topic><topic>Menorrhagia</topic><topic>Menorrhagia - complications</topic><topic>Menorrhagia - enzymology</topic><topic>Menorrhagia - pathology</topic><topic>Myoma</topic><topic>Obstetrics and Gynecology</topic><topic>Pharmacology. Drug treatments</topic><topic>Progesterone - pharmacology</topic><topic>Uterine Neoplasms - complications</topic><topic>Uterine Neoplasms - enzymology</topic><topic>Uterine Neoplasms - pathology</topic><topic>Vascular Endothelial Growth Factor A - metabolism</topic><topic>VEGF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maia, Hugo</creatorcontrib><creatorcontrib>Casoy, Julio</creatorcontrib><creatorcontrib>Pimentel, Kleber</creatorcontrib><creatorcontrib>Correia, Tania</creatorcontrib><creatorcontrib>Athayde, Célia</creatorcontrib><creatorcontrib>Cruz, Thomaz</creatorcontrib><creatorcontrib>Coutinho, Elsimar Metzker</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Contraception (Stoneham)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maia, Hugo</au><au>Casoy, Julio</au><au>Pimentel, Kleber</au><au>Correia, Tania</au><au>Athayde, Célia</au><au>Cruz, Thomaz</au><au>Coutinho, Elsimar Metzker</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of oral contraceptives on vascular endothelial growth factor, Cox-2 and aromatase expression in the endometrium of uteri affected by myomas and associated pathologies</atitle><jtitle>Contraception (Stoneham)</jtitle><addtitle>Contraception</addtitle><date>2008-12-01</date><risdate>2008</risdate><volume>78</volume><issue>6</issue><spage>479</spage><epage>485</epage><pages>479-485</pages><issn>0010-7824</issn><eissn>1879-0518</eissn><coden>CCPTAY</coden><abstract>Abstract Background The study was conducted to evaluate vascular endothelial growth factor (VEGF), Cox-2 and aromatase expression in the endometrium of uteri with myomas and other associated pathologies. Study Design Hysteroscopy was performed in 118 women of reproductive age with myomas and menorrhagia, 40 of whom were using a pill containing 75 mcg gestodene+30 mcg ethinylestradiol. Aromatase p450, VEGF and Cox-2 expression was detected using immunohistochemistry. Fisher's Exact Test and the Mann–Whitney test were used in the statistical analysis, with significance established at p<.05. Results In patients with myomas and menorrhagia, associated pathologies such as adenomyosis, endometrial polyps and endometriosis were found in 32%, 12% and 17% of cases, respectively. Aromatase, Cox-2 and VEGF expression was greater during the proliferative phase compared to the luteal phase of the cycle or following oral contraceptive use. Conclusion Endogenous progesterone or combined oral contraceptives are potent inhibitors of VEGF, aromatase and Cox-2 expression in the endometrium of patients with myomas and menorrhagia.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>19014794</pmid><doi>10.1016/j.contraception.2008.07.002</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aromatase Aromatase - metabolism Biological and medical sciences Birth control Contraceptives, Oral - pharmacology Cox-2 Cyclooxygenase 2 - metabolism Endometrium - enzymology Endometrium - metabolism Endometrium - pathology Female Genital system. Reproduction Gestodene Gynecology. Andrology. Obstetrics Hormonal contraception Humans Hysterectomy Immunohistochemistry Luteal Phase Medical sciences Menorrhagia Menorrhagia - complications Menorrhagia - enzymology Menorrhagia - pathology Myoma Obstetrics and Gynecology Pharmacology. Drug treatments Progesterone - pharmacology Uterine Neoplasms - complications Uterine Neoplasms - enzymology Uterine Neoplasms - pathology Vascular Endothelial Growth Factor A - metabolism VEGF |
| title | Effect of oral contraceptives on vascular endothelial growth factor, Cox-2 and aromatase expression in the endometrium of uteri affected by myomas and associated pathologies |
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