State of the art and perspectives for the delivery of antisense oligonucleotides and siRNA by polymeric nanocarriers
Knocking down gene expression using either antisense oligonucleotides (AS-ODNs) or small interfering RNA (siRNAs) has raised a lot of interest in designing new pathways for therapeutics. Despite their potentialities, these negatively charged and hydrophilic molecules request chemical modifications o...
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| Veröffentlicht in: | International journal of pharmaceutics 2008-12, Vol.364 (2), p.237-248 |
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| container_title | International journal of pharmaceutics |
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| creator | Fattal, Elias Bochot, Amélie |
| description | Knocking down gene expression using either antisense oligonucleotides (AS-ODNs) or small interfering RNA (siRNAs) has raised a lot of interest in designing new pathways for therapeutics. Despite their potentialities, these negatively charged and hydrophilic molecules request chemical modifications or a carrier that allows cell recognition, cell internalization and moreover subcellular penetration. Although chemical modifications were brought to the basic AS-ODNs and siRNAs, their sensitivity to degradation and poor intracellular penetration is still hampering their clinical applications. We present here the potentialities of polymeric carriers or the use of alternative administration route such as oral, ocular and skin delivery to improve their delivery and to circumvent the hurdles for their clinical applications. |
| doi_str_mv | 10.1016/j.ijpharm.2008.06.011 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0378-5173 |
| ispartof | International journal of pharmaceutics, 2008-12, Vol.364 (2), p.237-248 |
| issn | 0378-5173 1873-3476 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antisense oligonucleotides Bioavailability Biological Transport Cationic polymers Drug Carriers Drug Delivery Systems Gene Expression Regulation - drug effects Humans Nanoparticles Nanoparticles - administration & dosage Oligonucleotides, Antisense - administration & dosage Permeability Pharmacokinetics Polymers - administration & dosage RNA, Small Interfering - administration & dosage siRNA |
| title | State of the art and perspectives for the delivery of antisense oligonucleotides and siRNA by polymeric nanocarriers |
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