Improved Clearance of Mycobacterium avium Upon Disruption of the Inducible Nitric Oxide Synthase Gene

Mice genetically deficient in the inducible NO synthase gene (iNOS-/-) were used to study the role played by NO during infection by Mycobacterium avium. iNOS-/- macrophages were equally able to restrict M. avium growth in vitro following stimulation by IFN-gamma and TNF-alpha as macrophages from wil...

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Veröffentlicht in:	The Journal of immunology (1950) 1999-06, Vol.162 (11), p.6734-6739
Hauptverfasser:	Gomes, M. Salome, Florido, Manuela, Pais, Teresa F, Appelberg, Rui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Female Interferon-gamma - biosynthesis Interferon-gamma - physiology Macrophages - enzymology Macrophages - immunology Macrophages - microbiology Male Mice Mice, Inbred C57BL Mice, Inbred Strains Mice, Knockout Mycobacterium avium Mycobacterium avium - growth & development Mycobacterium avium - immunology Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type II Species Specificity Tuberculosis - enzymology Tuberculosis - immunology Tuberculosis - microbiology
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