Clinical significance of cyclin‐dependent kinase inhibitor p27Kip1 expression and proliferation in non‐Hodgkin's lymphoma: independent prognostic value of p27Kip1
The cyclin‐dependent kinase inhibitor p27Kip1 is a negative cell cycle regulator linking extracellular growth‐regulatory signals to the cell cycle machinery in G1. We investigated the pattern and prognostic value of p27Kip1 expression in a population‐based group of 203 non‐Hodgkin's lymphoma (N...
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| Veröffentlicht in: | British journal of haematology 1999-06, Vol.105 (3), p.730-736 |
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| creator | Møller, Michael B. Skjødt, Karsten Mortensen, Leif S. Pedersen, Niels T. |
| description | The cyclin‐dependent kinase inhibitor p27Kip1 is a negative cell cycle regulator linking extracellular growth‐regulatory signals to the cell cycle machinery in G1. We investigated the pattern and prognostic value of p27Kip1 expression in a population‐based group of 203 non‐Hodgkin's lymphoma (NHL) patients. The expression of p27Kip1 was identified by immunohistochemistry and correlated with Ki‐67 expression and clinical features. Correlation with outcome was determined using uni‐ and multivariate analysis stratified by clinical grade. Except for very aggressive NHL, there was a negative correlation between p27Kip1 and Ki‐67 expression. Low expression of p27Kip1, defined as nuclear p27Kip1 expression in 40%) was associated with poor survival in indolent and aggressive lymphomas. Multivariate analysis using the proportional hazards model showed that only p27Kip1, and not Ki‐67, maintained independent prognostic significance in indolent and aggressive lymphomas (relative risk = 2.0; P = 0.0095). The low cost and simplicity of this standard immunohistochemistry analysis makes p27Kip1 a promising and suitable prognostic marker in routine diagnostic laboratories in a standard diagnostic panel. |
| doi_str_mv | 10.1046/j.1365-2141.1999.01417.x |
| format | Article |
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We investigated the pattern and prognostic value of p27Kip1 expression in a population‐based group of 203 non‐Hodgkin's lymphoma (NHL) patients. The expression of p27Kip1 was identified by immunohistochemistry and correlated with Ki‐67 expression and clinical features. Correlation with outcome was determined using uni‐ and multivariate analysis stratified by clinical grade. Except for very aggressive NHL, there was a negative correlation between p27Kip1 and Ki‐67 expression. Low expression of p27Kip1, defined as nuclear p27Kip1 expression in <40% of malignant cells, was predictive of poor survival in indolent and aggressive NHL. However, even in this regard, very aggressive lymphomas behaved differently as those with low p27Kip1 expression tended to do better. Likewise, a high proliferation rate (Ki‐67 >40%) was associated with poor survival in indolent and aggressive lymphomas. Multivariate analysis using the proportional hazards model showed that only p27Kip1, and not Ki‐67, maintained independent prognostic significance in indolent and aggressive lymphomas (relative risk = 2.0; P = 0.0095). The low cost and simplicity of this standard immunohistochemistry analysis makes p27Kip1 a promising and suitable prognostic marker in routine diagnostic laboratories in a standard diagnostic panel.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1046/j.1365-2141.1999.01417.x</identifier><identifier>PMID: 10354138</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford, U.K. and Cambridge, USA: Blackwell Science Ltd</publisher><subject>Adult ; Biological and medical sciences ; Cell Cycle Proteins ; Cell Division ; Cyclin-Dependent Kinase Inhibitor p27 ; Enzyme Inhibitors - metabolism ; Follow-Up Studies ; Hematologic and hematopoietic diseases ; Humans ; Immunohistochemistry ; Leukemias. Malignant lymphomas. Malignant reticulosis. 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We investigated the pattern and prognostic value of p27Kip1 expression in a population‐based group of 203 non‐Hodgkin's lymphoma (NHL) patients. The expression of p27Kip1 was identified by immunohistochemistry and correlated with Ki‐67 expression and clinical features. Correlation with outcome was determined using uni‐ and multivariate analysis stratified by clinical grade. Except for very aggressive NHL, there was a negative correlation between p27Kip1 and Ki‐67 expression. Low expression of p27Kip1, defined as nuclear p27Kip1 expression in <40% of malignant cells, was predictive of poor survival in indolent and aggressive NHL. However, even in this regard, very aggressive lymphomas behaved differently as those with low p27Kip1 expression tended to do better. Likewise, a high proliferation rate (Ki‐67 >40%) was associated with poor survival in indolent and aggressive lymphomas. Multivariate analysis using the proportional hazards model showed that only p27Kip1, and not Ki‐67, maintained independent prognostic significance in indolent and aggressive lymphomas (relative risk = 2.0; P = 0.0095). The low cost and simplicity of this standard immunohistochemistry analysis makes p27Kip1 a promising and suitable prognostic marker in routine diagnostic laboratories in a standard diagnostic panel.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cell Cycle Proteins</subject><subject>Cell Division</subject><subject>Cyclin-Dependent Kinase Inhibitor p27</subject><subject>Enzyme Inhibitors - metabolism</subject><subject>Follow-Up Studies</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>lymphoma</subject><subject>Lymphoma, Non-Hodgkin - metabolism</subject><subject>Lymphoma, Non-Hodgkin - pathology</subject><subject>Medical sciences</subject><subject>Microtubule-Associated Proteins - metabolism</subject><subject>Middle Aged</subject><subject>p27</subject><subject>Prognosis</subject><subject>proliferation</subject><subject>Tumor Suppressor Proteins</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkU2O1DAQhS0EYpqBKyAvEKwS_BPHMRKLoQU0MBIbWFuOU-lx49ghTkP3jiNwCg7GSXBmGoaVS_W-ei7VQwhTUlJS1c93JeW1KBitaEmVUiXJlSwPd9Dqn3AXrQghssgDzRl6kNKOEMqJoPfRGSVcVJQ3K_Rr7V1w1nic3Da4PpfBAo49tkebpd8_fnYwQuggzPiLCyYBduHKtW6OEx6Z_OBGiuEwTpCSiwGb0OFxit71MJl56biAQ1yMNrHbZotnCfvjMF7FwbzI4q19HtuGmGZn8Tfj99dbnH54iO71xid4dHrP0ec3rz-tN8Xlx7fv1heXxUi5lAXQVjSgiATFDeu7RkAN0Na0a6lgjACznFXC1rQxtldNlxuUWA6S1a2SlJ-jpze-eZeve0izHlyy4L0JEPdJ10qqhtUig49P4L4doNPj5AYzHfXfy2bgyQkwKZ-3n_JdXbrlGl4JtWAvb7DvzsPxPxu9BK13eslTL3nqJWh9HbQ-6FfvN0vF_wCuP6Cr</recordid><startdate>199906</startdate><enddate>199906</enddate><creator>Møller, Michael B.</creator><creator>Skjødt, Karsten</creator><creator>Mortensen, Leif S.</creator><creator>Pedersen, Niels T.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199906</creationdate><title>Clinical significance of cyclin‐dependent kinase inhibitor p27Kip1 expression and proliferation in non‐Hodgkin's lymphoma: independent prognostic value of p27Kip1</title><author>Møller, Michael B. ; Skjødt, Karsten ; Mortensen, Leif S. ; Pedersen, Niels T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p1377-e1b58e907e93a2fd85e6eeb61db15220e2c3245c618acf98de2c10c3e726b9713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cell Cycle Proteins</topic><topic>Cell Division</topic><topic>Cyclin-Dependent Kinase Inhibitor p27</topic><topic>Enzyme Inhibitors - metabolism</topic><topic>Follow-Up Studies</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>lymphoma</topic><topic>Lymphoma, Non-Hodgkin - metabolism</topic><topic>Lymphoma, Non-Hodgkin - pathology</topic><topic>Medical sciences</topic><topic>Microtubule-Associated Proteins - metabolism</topic><topic>Middle Aged</topic><topic>p27</topic><topic>Prognosis</topic><topic>proliferation</topic><topic>Tumor Suppressor Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Møller, Michael B.</creatorcontrib><creatorcontrib>Skjødt, Karsten</creatorcontrib><creatorcontrib>Mortensen, Leif S.</creatorcontrib><creatorcontrib>Pedersen, Niels T.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Møller, Michael B.</au><au>Skjødt, Karsten</au><au>Mortensen, Leif S.</au><au>Pedersen, Niels T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical significance of cyclin‐dependent kinase inhibitor p27Kip1 expression and proliferation in non‐Hodgkin's lymphoma: independent prognostic value of p27Kip1</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>1999-06</date><risdate>1999</risdate><volume>105</volume><issue>3</issue><spage>730</spage><epage>736</epage><pages>730-736</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>The cyclin‐dependent kinase inhibitor p27Kip1 is a negative cell cycle regulator linking extracellular growth‐regulatory signals to the cell cycle machinery in G1. We investigated the pattern and prognostic value of p27Kip1 expression in a population‐based group of 203 non‐Hodgkin's lymphoma (NHL) patients. The expression of p27Kip1 was identified by immunohistochemistry and correlated with Ki‐67 expression and clinical features. Correlation with outcome was determined using uni‐ and multivariate analysis stratified by clinical grade. Except for very aggressive NHL, there was a negative correlation between p27Kip1 and Ki‐67 expression. Low expression of p27Kip1, defined as nuclear p27Kip1 expression in <40% of malignant cells, was predictive of poor survival in indolent and aggressive NHL. However, even in this regard, very aggressive lymphomas behaved differently as those with low p27Kip1 expression tended to do better. Likewise, a high proliferation rate (Ki‐67 >40%) was associated with poor survival in indolent and aggressive lymphomas. Multivariate analysis using the proportional hazards model showed that only p27Kip1, and not Ki‐67, maintained independent prognostic significance in indolent and aggressive lymphomas (relative risk = 2.0; P = 0.0095). The low cost and simplicity of this standard immunohistochemistry analysis makes p27Kip1 a promising and suitable prognostic marker in routine diagnostic laboratories in a standard diagnostic panel.</abstract><cop>Oxford, U.K. and Cambridge, USA</cop><pub>Blackwell Science Ltd</pub><pmid>10354138</pmid><doi>10.1046/j.1365-2141.1999.01417.x</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Biological and medical sciences Cell Cycle Proteins Cell Division Cyclin-Dependent Kinase Inhibitor p27 Enzyme Inhibitors - metabolism Follow-Up Studies Hematologic and hematopoietic diseases Humans Immunohistochemistry Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis lymphoma Lymphoma, Non-Hodgkin - metabolism Lymphoma, Non-Hodgkin - pathology Medical sciences Microtubule-Associated Proteins - metabolism Middle Aged p27 Prognosis proliferation Tumor Suppressor Proteins |
| title | Clinical significance of cyclin‐dependent kinase inhibitor p27Kip1 expression and proliferation in non‐Hodgkin's lymphoma: independent prognostic value of p27Kip1 |
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