Laparoscopic gastric resection for gastrointestinal stromal tumors

Background This study aimed to review clinical outcomes for patients selected to undergo laparoscopic resection for gastrointestinal stromal tumor (GIST) of the stomach. Methods All 112 laparoscopic gastric resections performed from February 1995 to March 2007 were reviewed. Pre- and postoperative v...

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Veröffentlicht in:Surgical endoscopy 2008-12, Vol.22 (12), p.2583-2587
Hauptverfasser: Sexton, Jennifer A., Pierce, Richard A., Halpin, Valerie J., Eagon, J. Christopher, Hawkins, William G., Linehan, David C., Brunt, L. Michael, Frisella, Margaret M., Matthews, Brent D.
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container_end_page 2587
container_issue 12
container_start_page 2583
container_title Surgical endoscopy
container_volume 22
creator Sexton, Jennifer A.
Pierce, Richard A.
Halpin, Valerie J.
Eagon, J. Christopher
Hawkins, William G.
Linehan, David C.
Brunt, L. Michael
Frisella, Margaret M.
Matthews, Brent D.
description Background This study aimed to review clinical outcomes for patients selected to undergo laparoscopic resection for gastrointestinal stromal tumor (GIST) of the stomach. Methods All 112 laparoscopic gastric resections performed from February 1995 to March 2007 were reviewed. Pre- and postoperative variables were analyzed, and data are given as mean ± standard deviation. Results Laparoscopic gastric resection was attempted for 63 GIST in 61 patients (31 men and 30 women) with a mean age was 59.1 ± 19 years. The tumors were located at the fundus ( n  = 19), antrum ( n  = 18), body ( n  = 17), gastroesophageal junction/cardia ( n  = 7), and pylorus ( n  = 2). Common presentations were upper gastrointestinal bleed ( n  = 29) and incidental finding on esophagogastroduodenoscopy ( n  = 17). The laparoscopic procedures performed were partial gastrectomy ( n  = 52), antrectomy ( n  = 4), esophagogastrectomy ( n  = 3), and endoscopically assisted and/or transgastric resection ( n  = 3). There was one conversion to open procedure for control of bleeding from the spleen. The mean tumor size was 3.8 ± 1.8 cm. Negative surgical margins were achieved in all but one case. The mean operative time was 151.9 ± 67.3 min, and the mean estimated blood loss was 97.4 ± 200.7 ml. A regular diet was resumed at a mean of 2.9 ± 1.6 days, and the mean length of hospital stay was 3.9 ± 2.2 days. The perioperative complication rate was 16.4% including deep vein thrombosis postoperative bleed, anastomotic stricture, and incisional hernia. One mortality occurred, due to respiratory failure. The GISTs included 48 rated as low risk, six rated as intermediate risk, and nine rated as high malignant potential. At a mean follow-up period of 15 ± 21.8 months (range, 0–103 months), three of nine patients with high malignant potential GIST experienced, respectively, metastatic disease to the liver, liver and lung, and peritoneum. At this writing, all the other patients are disease free. Conclusions Laparoscopic gastric resection for GIST is a feasible option. Adequate oncologic resection was achieved with 98.4% of patients chosen for laparoscopic resection. Resection margin positivity and recurrence rates are low after laparoscopic approaches for appropriately selected patients with GIST, demonstrating favorable characteristics.
doi_str_mv 10.1007/s00464-008-9807-1
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Christopher ; Hawkins, William G. ; Linehan, David C. ; Brunt, L. Michael ; Frisella, Margaret M. ; Matthews, Brent D.</creator><creatorcontrib>Sexton, Jennifer A. ; Pierce, Richard A. ; Halpin, Valerie J. ; Eagon, J. Christopher ; Hawkins, William G. ; Linehan, David C. ; Brunt, L. Michael ; Frisella, Margaret M. ; Matthews, Brent D.</creatorcontrib><description>Background This study aimed to review clinical outcomes for patients selected to undergo laparoscopic resection for gastrointestinal stromal tumor (GIST) of the stomach. Methods All 112 laparoscopic gastric resections performed from February 1995 to March 2007 were reviewed. Pre- and postoperative variables were analyzed, and data are given as mean ± standard deviation. Results Laparoscopic gastric resection was attempted for 63 GIST in 61 patients (31 men and 30 women) with a mean age was 59.1 ± 19 years. The tumors were located at the fundus ( n  = 19), antrum ( n  = 18), body ( n  = 17), gastroesophageal junction/cardia ( n  = 7), and pylorus ( n  = 2). Common presentations were upper gastrointestinal bleed ( n  = 29) and incidental finding on esophagogastroduodenoscopy ( n  = 17). The laparoscopic procedures performed were partial gastrectomy ( n  = 52), antrectomy ( n  = 4), esophagogastrectomy ( n  = 3), and endoscopically assisted and/or transgastric resection ( n  = 3). There was one conversion to open procedure for control of bleeding from the spleen. The mean tumor size was 3.8 ± 1.8 cm. Negative surgical margins were achieved in all but one case. The mean operative time was 151.9 ± 67.3 min, and the mean estimated blood loss was 97.4 ± 200.7 ml. A regular diet was resumed at a mean of 2.9 ± 1.6 days, and the mean length of hospital stay was 3.9 ± 2.2 days. The perioperative complication rate was 16.4% including deep vein thrombosis postoperative bleed, anastomotic stricture, and incisional hernia. One mortality occurred, due to respiratory failure. The GISTs included 48 rated as low risk, six rated as intermediate risk, and nine rated as high malignant potential. At a mean follow-up period of 15 ± 21.8 months (range, 0–103 months), three of nine patients with high malignant potential GIST experienced, respectively, metastatic disease to the liver, liver and lung, and peritoneum. At this writing, all the other patients are disease free. Conclusions Laparoscopic gastric resection for GIST is a feasible option. Adequate oncologic resection was achieved with 98.4% of patients chosen for laparoscopic resection. Resection margin positivity and recurrence rates are low after laparoscopic approaches for appropriately selected patients with GIST, demonstrating favorable characteristics.</description><identifier>ISSN: 0930-2794</identifier><identifier>EISSN: 1432-2218</identifier><identifier>DOI: 10.1007/s00464-008-9807-1</identifier><identifier>PMID: 18322738</identifier><identifier>CODEN: SUREEX</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Abdominal Surgery ; Adolescent ; Aged ; Biological and medical sciences ; Digestive system. Abdomen ; Endoscopy ; Esophageal Neoplasms - surgery ; Esophagectomy - methods ; Esophagogastric Junction - surgery ; Female ; Follow-Up Studies ; Gastrectomy - methods ; Gastroenterology ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastrointestinal Stromal Tumors - surgery ; General aspects ; Gynecology ; Hepatology ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Laparoscopy - methods ; Male ; Medical sciences ; Medicine ; Medicine &amp; Public Health ; Middle Aged ; Neoplasm Metastasis ; Neoplasm Seeding ; Postoperative Complications - epidemiology ; Proctology ; Prognosis ; Pylorus - surgery ; Retrospective Studies ; Risk ; Stomach Neoplasms - surgery ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Surgery ; Treatment Outcome ; Tumors ; Young Adult</subject><ispartof>Surgical endoscopy, 2008-12, Vol.22 (12), p.2583-2587</ispartof><rights>Springer Science+Business Media, LLC 2008</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-759ceffdc98ca0309d3a045aea024a88e825f5a9417ad69d1b10004c330c67bb3</citedby><cites>FETCH-LOGICAL-c465t-759ceffdc98ca0309d3a045aea024a88e825f5a9417ad69d1b10004c330c67bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00464-008-9807-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00464-008-9807-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=20943867$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18322738$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sexton, Jennifer A.</creatorcontrib><creatorcontrib>Pierce, Richard A.</creatorcontrib><creatorcontrib>Halpin, Valerie J.</creatorcontrib><creatorcontrib>Eagon, J. Christopher</creatorcontrib><creatorcontrib>Hawkins, William G.</creatorcontrib><creatorcontrib>Linehan, David C.</creatorcontrib><creatorcontrib>Brunt, L. Michael</creatorcontrib><creatorcontrib>Frisella, Margaret M.</creatorcontrib><creatorcontrib>Matthews, Brent D.</creatorcontrib><title>Laparoscopic gastric resection for gastrointestinal stromal tumors</title><title>Surgical endoscopy</title><addtitle>Surg Endosc</addtitle><addtitle>Surg Endosc</addtitle><description>Background This study aimed to review clinical outcomes for patients selected to undergo laparoscopic resection for gastrointestinal stromal tumor (GIST) of the stomach. Methods All 112 laparoscopic gastric resections performed from February 1995 to March 2007 were reviewed. Pre- and postoperative variables were analyzed, and data are given as mean ± standard deviation. Results Laparoscopic gastric resection was attempted for 63 GIST in 61 patients (31 men and 30 women) with a mean age was 59.1 ± 19 years. The tumors were located at the fundus ( n  = 19), antrum ( n  = 18), body ( n  = 17), gastroesophageal junction/cardia ( n  = 7), and pylorus ( n  = 2). Common presentations were upper gastrointestinal bleed ( n  = 29) and incidental finding on esophagogastroduodenoscopy ( n  = 17). The laparoscopic procedures performed were partial gastrectomy ( n  = 52), antrectomy ( n  = 4), esophagogastrectomy ( n  = 3), and endoscopically assisted and/or transgastric resection ( n  = 3). There was one conversion to open procedure for control of bleeding from the spleen. The mean tumor size was 3.8 ± 1.8 cm. Negative surgical margins were achieved in all but one case. The mean operative time was 151.9 ± 67.3 min, and the mean estimated blood loss was 97.4 ± 200.7 ml. A regular diet was resumed at a mean of 2.9 ± 1.6 days, and the mean length of hospital stay was 3.9 ± 2.2 days. The perioperative complication rate was 16.4% including deep vein thrombosis postoperative bleed, anastomotic stricture, and incisional hernia. One mortality occurred, due to respiratory failure. The GISTs included 48 rated as low risk, six rated as intermediate risk, and nine rated as high malignant potential. At a mean follow-up period of 15 ± 21.8 months (range, 0–103 months), three of nine patients with high malignant potential GIST experienced, respectively, metastatic disease to the liver, liver and lung, and peritoneum. At this writing, all the other patients are disease free. Conclusions Laparoscopic gastric resection for GIST is a feasible option. Adequate oncologic resection was achieved with 98.4% of patients chosen for laparoscopic resection. Resection margin positivity and recurrence rates are low after laparoscopic approaches for appropriately selected patients with GIST, demonstrating favorable characteristics.</description><subject>Abdominal Surgery</subject><subject>Adolescent</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Digestive system. Abdomen</subject><subject>Endoscopy</subject><subject>Esophageal Neoplasms - surgery</subject><subject>Esophagectomy - methods</subject><subject>Esophagogastric Junction - surgery</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastrectomy - methods</subject><subject>Gastroenterology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gastrointestinal Stromal Tumors - surgery</subject><subject>General aspects</subject><subject>Gynecology</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Laparoscopy - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasm Seeding</subject><subject>Postoperative Complications - epidemiology</subject><subject>Proctology</subject><subject>Prognosis</subject><subject>Pylorus - surgery</subject><subject>Retrospective Studies</subject><subject>Risk</subject><subject>Stomach Neoplasms - surgery</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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Christopher ; Hawkins, William G. ; Linehan, David C. ; Brunt, L. Michael ; Frisella, Margaret M. ; Matthews, Brent D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-759ceffdc98ca0309d3a045aea024a88e825f5a9417ad69d1b10004c330c67bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Abdominal Surgery</topic><topic>Adolescent</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Digestive system. Abdomen</topic><topic>Endoscopy</topic><topic>Esophageal Neoplasms - surgery</topic><topic>Esophagectomy - methods</topic><topic>Esophagogastric Junction - surgery</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastrectomy - methods</topic><topic>Gastroenterology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gastrointestinal Stromal Tumors - surgery</topic><topic>General aspects</topic><topic>Gynecology</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Laparoscopy - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Metastasis</topic><topic>Neoplasm Seeding</topic><topic>Postoperative Complications - epidemiology</topic><topic>Proctology</topic><topic>Prognosis</topic><topic>Pylorus - surgery</topic><topic>Retrospective Studies</topic><topic>Risk</topic><topic>Stomach Neoplasms - surgery</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Surgery</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sexton, Jennifer A.</creatorcontrib><creatorcontrib>Pierce, Richard A.</creatorcontrib><creatorcontrib>Halpin, Valerie J.</creatorcontrib><creatorcontrib>Eagon, J. Christopher</creatorcontrib><creatorcontrib>Hawkins, William G.</creatorcontrib><creatorcontrib>Linehan, David C.</creatorcontrib><creatorcontrib>Brunt, L. Michael</creatorcontrib><creatorcontrib>Frisella, Margaret M.</creatorcontrib><creatorcontrib>Matthews, Brent D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Surgical endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sexton, Jennifer A.</au><au>Pierce, Richard A.</au><au>Halpin, Valerie J.</au><au>Eagon, J. Christopher</au><au>Hawkins, William G.</au><au>Linehan, David C.</au><au>Brunt, L. Michael</au><au>Frisella, Margaret M.</au><au>Matthews, Brent D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Laparoscopic gastric resection for gastrointestinal stromal tumors</atitle><jtitle>Surgical endoscopy</jtitle><stitle>Surg Endosc</stitle><addtitle>Surg Endosc</addtitle><date>2008-12-01</date><risdate>2008</risdate><volume>22</volume><issue>12</issue><spage>2583</spage><epage>2587</epage><pages>2583-2587</pages><issn>0930-2794</issn><eissn>1432-2218</eissn><coden>SUREEX</coden><abstract>Background This study aimed to review clinical outcomes for patients selected to undergo laparoscopic resection for gastrointestinal stromal tumor (GIST) of the stomach. Methods All 112 laparoscopic gastric resections performed from February 1995 to March 2007 were reviewed. Pre- and postoperative variables were analyzed, and data are given as mean ± standard deviation. Results Laparoscopic gastric resection was attempted for 63 GIST in 61 patients (31 men and 30 women) with a mean age was 59.1 ± 19 years. The tumors were located at the fundus ( n  = 19), antrum ( n  = 18), body ( n  = 17), gastroesophageal junction/cardia ( n  = 7), and pylorus ( n  = 2). Common presentations were upper gastrointestinal bleed ( n  = 29) and incidental finding on esophagogastroduodenoscopy ( n  = 17). The laparoscopic procedures performed were partial gastrectomy ( n  = 52), antrectomy ( n  = 4), esophagogastrectomy ( n  = 3), and endoscopically assisted and/or transgastric resection ( n  = 3). There was one conversion to open procedure for control of bleeding from the spleen. The mean tumor size was 3.8 ± 1.8 cm. Negative surgical margins were achieved in all but one case. The mean operative time was 151.9 ± 67.3 min, and the mean estimated blood loss was 97.4 ± 200.7 ml. A regular diet was resumed at a mean of 2.9 ± 1.6 days, and the mean length of hospital stay was 3.9 ± 2.2 days. The perioperative complication rate was 16.4% including deep vein thrombosis postoperative bleed, anastomotic stricture, and incisional hernia. One mortality occurred, due to respiratory failure. The GISTs included 48 rated as low risk, six rated as intermediate risk, and nine rated as high malignant potential. At a mean follow-up period of 15 ± 21.8 months (range, 0–103 months), three of nine patients with high malignant potential GIST experienced, respectively, metastatic disease to the liver, liver and lung, and peritoneum. At this writing, all the other patients are disease free. Conclusions Laparoscopic gastric resection for GIST is a feasible option. Adequate oncologic resection was achieved with 98.4% of patients chosen for laparoscopic resection. Resection margin positivity and recurrence rates are low after laparoscopic approaches for appropriately selected patients with GIST, demonstrating favorable characteristics.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>18322738</pmid><doi>10.1007/s00464-008-9807-1</doi><tpages>5</tpages></addata></record>
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subjects Abdominal Surgery
Adolescent
Aged
Biological and medical sciences
Digestive system. Abdomen
Endoscopy
Esophageal Neoplasms - surgery
Esophagectomy - methods
Esophagogastric Junction - surgery
Female
Follow-Up Studies
Gastrectomy - methods
Gastroenterology
Gastroenterology. Liver. Pancreas. Abdomen
Gastrointestinal Stromal Tumors - surgery
General aspects
Gynecology
Hepatology
Humans
Investigative techniques, diagnostic techniques (general aspects)
Laparoscopy - methods
Male
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Metastasis
Neoplasm Seeding
Postoperative Complications - epidemiology
Proctology
Prognosis
Pylorus - surgery
Retrospective Studies
Risk
Stomach Neoplasms - surgery
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Surgery
Treatment Outcome
Tumors
Young Adult
title Laparoscopic gastric resection for gastrointestinal stromal tumors
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